PhysIOpathology of NEuromuscular function rElated to fatigue in chronic Renal disease in the elderly (PIONEER): study protocol

Chatrenet, Antoine; Beaune, Bruno; Fois, Antioco; Pouliquen, Camille; Audebrand, J.-M.; Torreggiani, Massimo; Paris, Damien B.B.P.; Durand, Sylvain; Piccoli, Giorgina Barbara

doi:10.1186/s12882-020-01976-6

Cited by 3 publications

(5 citation statements)

References 54 publications

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“…Before electrode placement, the skin was shaved and wiped clean with 70° alcohol. Four sensors were placed on the Flexor Digitorum Superficialis and hold with a double‐sided tape and kinesiology taping while following the SENIAM recommendations and the previous anatomical location described 26 …”

Section: Methodsmentioning

confidence: 99%

“…The study is prospective, single centre and observational. It is a part of the PIONEER project (PhysIOpathology of NEuromuscular function rElated to fatigue in chronic Renal disease in the elderly 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…Four sensors were placed on the Flexor Digitorum Superficialis and hold with a double-sided tape and kinesiology taping while following the SENIAM recommendations and the previous anatomical location described. 26 The participant gets direct visual feedback of the force and the sEMG by means of an interface created through LabVIEW v19.0.1 (National Instruments Corp., Austin, TX, USA). The targeted force of the submaximal contractions (40 ± 10% MVF) is represented as a coloured horizontal band in the force-time graphic.…”

Section: Data Acquisitionmentioning

confidence: 99%

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Analysis of the rate of force development reveals high neuromuscular fatigability in elderly patients with chronic kidney disease

Chatrenet

Piccoli

Audebrand

et al. 2023

J cachexia sarcopenia muscle

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BackgroundChronic kidney disease (CKD) induces muscle wasting and a reduction in the maximum voluntary force (MVF). Little is known about the neuromuscular fatigability in CKD patients, defined as the reduction of muscle force capacities during exercise. Neuromuscular fatigability is a crucial physical parameter of the daily living. The quantification of explosive force has been shown to be a sensitive means to assess neuromuscular fatigability. Thus, our study used explosive force estimates to assess neuromuscular fatigability in elderly CKD patients.MethodsInclusion criteria for CKD patients were age ≥ 60 years old and glomerular filtration rate (GFR) < 45 mL/min/1.73 m2 not on dialysis, and those for controls were GFR > 60 mL/min/1.73 m2, age and diabetes matched. The fatigability protocol focused on a handgrip task coupled with surface electromyography (sEMG). Scalars were extracted from the rate of force development (RFD): absolute and normalized time periods (50, 75, 100, 150 and 200 ms, RFD50, RFD75, RFD100, RFD150 and RFD200, respectively), peak RFD (RFDpeak in absolute; NRFDpeak normalized), time‐to‐peak RFD (t‐RFDpeak) and the relative force at RFDpeak (MVF‐RFDpeak). A statistical parametric mapping approach was performed on the force, impulse and RFD–time curves. The integrated sEMG with time at 0–30, 0–50, 0–100 and 0–200 ms time intervals relative to onset of sEMG activity was extracted and groups were compared separately for each sex.ResultsThe cohort of 159 individuals had a median age of 69 (9IQR) years and body mass index was 27.6 (6.2IQR) kg/m2. Propensity‐score‐matched groups balanced CKD patients and controls by gender with 66 males and 34 females. In scalar analysis, CKD patients manifested a higher decrement than controls in the early phase of contraction, regarding the NRFDpeak (P = 0.009; η2p = 0.034) and RFD75 and RFD100 (for both P < 0.001; η2p = 0.068 and 0.064). The one‐dimensional analysis confirmed that CKD males manifest higher and delayed neuromuscular fatigability, especially before 100 ms from onset of contraction. sEMG was lower in CKD patients than controls in the 0–100 ms (at rest: P = 0.049, Cohen's d = 0.458) and 0–200 ms (at rest: P = 0.016, Cohen's d = 0.496; during exercise: P = 0.006, Cohen's d = 0.421) time windows. Controls showed greater decrease of sEMG than CKD patients in the 0–30 ms (P = 0.020, Cohen's d = 0.533) and 0–50 ms (P = 0.010, Cohen's d = 0.640) time windows. As opposite to females, males showed almost the same differences between groups.ConclusionsOur study is the first to show that CKD patients have higher fatigability than controls, which may be associated with an impaired motor‐unit recruitment, highlighting a neural drive disturbance with CKD. Further studies are needed to confirm these findings.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Data Acquisitionmentioning

confidence: 99%

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Analysis of the rate of force development reveals high neuromuscular fatigability in elderly patients with chronic kidney disease

Chatrenet

Piccoli

Audebrand

et al. 2023

J cachexia sarcopenia muscle

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“…Study organization. Our cross-sectional single-center observational study was part of the Physiopathology of Neuromuscular Function Related to Fatigue in Chronic Renal Disease in the Elderly (PIONEER) (18) project. It was approved by Ethical Committee Est-III of the Nancy University Hospital Centre (no.…”

Section: Methodsmentioning

confidence: 99%

“…Data were analyzed using RStudio v.4.0.5 (R Core Team 2021, Vienna, AT). The inclusion period ended before reaching the a priori sample size calculated ( n = 220 for 96% statistical power) (18) because of an underestimation of the outcome (∆8% chosen, ∆11% observed). Continuous data were tested for normality using the Shapiro–Wilk test and displayed as mean and SD, or median and interquartile range (IQR).…”

Section: Methodsmentioning

confidence: 99%

Neural Drive Impairment in Chronic Kidney Disease Patients Is Associated with Neuromuscular Fatigability and Fatigue

Chatrenet

Piccoli

Anthierens

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction: Chronic kidney disease (CKD) patients have a high degree of fatigue relating to neuromuscular symptoms. There is a lack of evidence regarding the etiology of neuromuscular fatigability in elderly CKD patients. Methods: Inclusion criteria are as follows: age ≥60 yr, glomerular filtration rate (GFR) <45 mL•min −1 per 1.73 m 2 in CKD patients, and GFR >60 mL•min −1 •1.73 m −2 in controls. The fatigability protocol consisted in a submaximal handgrip task at 40% peak force. Fatigue was assessed using the Multidimensional Fatigue Inventory-20 items (MFI-20) and the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaires. Peak rate of force development (RFD peak , normalized: NRFD peak ) and rate of EMG rise (RER) were measured during explosive contractions; peak force and mean surface EMG were measured during maximum voluntary contractions. Multilevel models tested neuromuscular parameters adjusted for clinical and Multidimensional Fatigue Inventory-20 items subscales. Neuromuscular fatigability contribution to fatigue description was tested using model comparison. Results: The study included 102 participants; 45 CKD patients and 57 controls. CKD mainly affected the mental and the reduced motivation subscales of fatigue. CKD was associated with greater neuromuscular fatigability assessed using NRFD peak (group-time interaction, −16.7 % MVF•s −1 , P = 0.024), which increased with fatigue severity ( P = 0.018) and with a higher rate of decrement in RER compared with controls (RER at 50 ms: β = −121.2 μV•s −1 , P = 0.016, and β = −48.5 μV•s −1 , P = 0.196, respectively). Furthermore, these patients show an association between the reduced motivation subscale and the RER (e.g., 30 ms: β = −59.8% EMG peak •s −1 , P < 0.001). Only peak force fatigability contributed to fatigue variance, whereas RFD peak did not. Conclusions: In CKD patients, the neuromuscular fatigability assessed using RFD peak is related to an impairment in motor-unit recruitment or discharge rates, whereas only peak force fatigability was related to fatigue. This suggests that targeting exercise interventions might lessen fatigue and improve quality of life in CKD patients.

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Hemodynamic and neuromuscular basis of reduced exercise capacity in patients with end-stage renal disease

Machfer,

Tagougui,

Zghal

et al. 2024

Eur J Appl Physiol

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PhysIOpathology of NEuromuscular function rElated to fatigue in chronic Renal disease in the elderly (PIONEER): study protocol

Cited by 3 publications

References 54 publications

Analysis of the rate of force development reveals high neuromuscular fatigability in elderly patients with chronic kidney disease

Analysis of the rate of force development reveals high neuromuscular fatigability in elderly patients with chronic kidney disease

Neural Drive Impairment in Chronic Kidney Disease Patients Is Associated with Neuromuscular Fatigability and Fatigue

Hemodynamic and neuromuscular basis of reduced exercise capacity in patients with end-stage renal disease

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