Physisorption behavior of enflurane on the dipalmitoyl phosphatidyl choline (DPPC) monolayer using high sensitive quartz crystal oscillator method

Yamämoto, Yasushi; Shervani, Zameer; Shimoaki, Takatsugu; Yokoyama, Takashi; Ando, Tomoyo; Somekawa, Asuka; Takayama, Mariko; Tamaoki, Kenta; Yoshida, Tadayoshi; Taga, Keijiro; Kamaya, Hiroshi; Ueda, I.

doi:10.1016/j.colsurfa.2010.06.015

Cited by 9 publications

(16 citation statements)

References 27 publications

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“…The Δf values were -2.1 Hz for the DHP monolayer while observed Δm was 25.6 ng/cm 2 and -3.1 Hz for the DPPC monolayer and Δm: 37.8 ng/cm 2 . Our recent concentration-dependence study with regard to the interaction of enflurane with the DPPC monolayer revealed that Δf of -3.1 Hz at 4 mM is nearly to the initial saturation value that corresponds to the amount of semi-saturated physisorption layer of enflurane hydrates [23]. Table 1 summarizes the Δf and Δm values of the DHP and DPPC monolayers interacting with halothane and enflurance anesthatics.…”

Section: Hs-qcm Measurementsmentioning

confidence: 98%

“…Enflurane hydrates, on the other hand, whose molecular axis are physisorption capable due to large size anethetic can physisorb ( Table 1) at even the smooth and smaller DHP monolayer/water interface. Many enflurane hydrates physisorb easily on the DPPC monolayer/water interface and reach to a semi saturated physisorption state [23] because of the existence of more physisorption sites or acceptors (Figure 5(d)).…”

Section: Monolayer-anesthetic Interactionmentioning

confidence: 99%

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Study of physisorption of volatile anesthetics on phos-pholipid monolayers using a highly sensitive quartz crystal microbalance (HS-QCM)

Yamämoto¹,

Shervani²,

Shimoaki³

et al. 2011

JBPC

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We have investigated the interactions between phospholipid monolayers and volatile anest-hatics. Two monolayers (dihexadecyl phosphate (DHP) and dipalmitoyl phosphatidyl choline (DPPC) and two anesthetics (halothane and enflurane) were used to observe these interac-tions using a highly sensitive quartz crystal microbalance (HS-QCM). The concentration of each anesthetic in aqueous solution was kept at 4 mM. The frequency of QCM showed no change when halothane was added to the DHP monolayer, however, it responded and de-creased when interaction occurred with DPPC monolayer. In case of enflurane addition the frequency decreased in both the monolayers of DHP and DPPC. The frequency change followed the following order of monolayer-anesthetic interactions: DHP-halothane <DPPC-halothane <DHP-enflurane <DPPC-enflurane. These re-sults showed that the response of anesthetics to the monolayers i.e. the physisorption not only depends on the anesthetic structure, the type of anesthetic hydrate formed, but also the hydrophilic polar group structure of the monolayer or the monolayer/water interface had an important role in physisorption

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Section: Hs-qcm Measurementsmentioning

confidence: 98%

Section: Monolayer-anesthetic Interactionmentioning

confidence: 99%

Study of physisorption of volatile anesthetics on phos-pholipid monolayers using a highly sensitive quartz crystal microbalance (HS-QCM)

Yamämoto¹,

Shervani²,

Shimoaki³

et al. 2011

JBPC

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“…Investigations [10] [12] show anesthetic strength or anesthetic potency is temperature dependent. Various studies [8] [9] [13]- [15] conducted based on experimental and clinical facts reach to the conclusion that anesthesia phenomena is physisorption where anesthetic aggregation acts indirectly on biomembrane-body fluid interface. Among various physicochemical techniques, quartz crystal oscillator (QCO) method is a powerful tool to investigate the interactional phenomena in liquid phases.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we have investigated physisorption interactions between phospholipid monolayers (dipalmitoyl phosphatidyl choline, DPPC; dimyristoyl phosphatidyl choline, DMPC) as the model membrane and anesthetic isoflurane using our home designed and assembled high sensitive QCO apparatus [15] [27]- [29], where the QCO was attached horizontally on those monolayers formed on the water surface. DPPC and DMPC are one of main components on the membrane and have the following characteristics on the point of "molecule"; these have a common hydrophilic phosphatidyl choline group, while the length of two alkyl chains is different (DPPC is longer than DMPC).…”

Section: Introductionmentioning

confidence: 99%

Interactions between Phospholipid Monolayers (DPPC and DMPC) and Anesthetic Isoflurane Observed by Quartz Crystal Oscillator

Yamämoto¹,

Yokoyama²,

Yoshida³

et al. 2015

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The interactions of phospholipid monolayers (dipalmitoyl phosphatidyl choline; DPPC and dimyristoyl phosphatidyl choline; DMPC) with volatile anesthetic isoflurane were investigated using quartz crystal microbalance (QCM) and quartz crystal impedance (QCI) methods. The quartz crystal oscillator was attached horizontally on the surface of DPPC and DMPC monolayer formed on the water surface. Physisorption of isoflurane hydrate at the DPPC monolayer surface was monitored in terms of frequency and resistance change of quartz crystal on addition of anesthetics isoflurane. Both frequency and resistance change showed the elastic nature of DPPC monolayer. Measurement of DMPC monolayer-isoflurane hydrate revealed the expandable nature of DMPC monolayer. Variation of frequency and impedance of DPPC and DMPC monolayer on addition of isoflurane which proved a two-step change has occurred at monolayer surface at isoflurane concentration of <8 mM that has been attributed to isoflurane aggregation at monolayer/water interface. Isoflurane hydrates formed in the process have capability to affect the interfacial properties of monolayer such as existence of structured water.

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“…Furthermore, the adsorption of carbon dioxide on sugar acetate surfaces showed a high dependence on the molecular structure of the film and it was suggested that sugar acetates could find application in the separation of carbon dioxide (Ma et al ., ). Of biological relevance, the anaesthetic enflurane was detected on a dipalmitoyl phosphatidyl choline monolayer in order to further probe the mechanism of action (Yamamoto et al ., ).…”

Section: Small Molecule Interactionsmentioning

confidence: 97%

A Survey of the 2010 Quartz Crystal Microbalance Literature

Speight

Cooper

2012

J of Molecular Recognition

135

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In 2010 there has again been an increase in the number of papers published involving piezoelectric acoustic sensors, or quartz crystal microbalances (QCM), when compared to the last period reviewed 2006-2009. The average number of QCM publications per annum was 124 in the period 2001-2005, 223 in the period 2006-9, and 273 in 2010. There are trends towards increasing use of QCM in the study of protein adsorption to surfaces (93% increase), homeostasis (67% increase), protein-protein interactions (40% increase), and carbohydrates (43% increase). New commercial systems have been released that are driving the uptake of the technology for characterisation of binding specificities, affinities, kinetics and conformational changes associated with a molecular recognition event. This article highlights theoretical and practical aspects of the principals that underpin acoustic analysis, then reviews exemplary papers in key application areas involving small molecular weight ligands, carbohydrates, proteins, nucleic acids, viruses, bacteria, cells, and membrane interfaces.

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Physisorption behavior of enflurane on the dipalmitoyl phosphatidyl choline (DPPC) monolayer using high sensitive quartz crystal oscillator method

Cited by 9 publications

References 27 publications

Study of physisorption of volatile anesthetics on phos-pholipid monolayers using a highly sensitive quartz crystal microbalance (HS-QCM)

Study of physisorption of volatile anesthetics on phos-pholipid monolayers using a highly sensitive quartz crystal microbalance (HS-QCM)

Interactions between Phospholipid Monolayers (DPPC and DMPC) and Anesthetic Isoflurane Observed by Quartz Crystal Oscillator

A Survey of the 2010 Quartz Crystal Microbalance Literature

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