2020
DOI: 10.7759/cureus.11739
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Physostigmine in Anticholinergic Poisoning: An Old Antidote With Resurgence

Abstract: Physostigmine is a cholinesterase inhibitor used therapeutically in patients with anticholinergic delirium that is so severe that intubation may be required for airway protection. Given that a wide variety of medications have anticholinergic properties, and the current standard of care is typically a central nervous system depressant, hospitalizations are often lengthy and normally require a critical-care level of attention. Despite this, physostigmine is often underutilized and poorly understood in the clinic… Show more

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