Phytoalexins of the crucifer Barbarea vulgaris: Structural profile and correlation with glucosinolate turnover

Cárdenas, Pablo D.; Landtved, Jonas P.; Larsen, Signe H.; Lindegaard, Nicolai; Wøhlk, Sebastian; Jensen, Karen R.; Pattison, David I.; Burow, Meike; Bak, Søren; Crocoll, Christoph; Agerbirk, Niels

doi:10.1016/j.phytochem.2023.113742

Cited by 4 publications

(1 citation statement)

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“…Indole glucosinolates are plausible direct precursors to a subset of indole phytoalexins, emphasizing their mutual biosynthetic pathway. Several labeling studies have demonstrated the de novo biosynthesis of indole phytoalexins from glucosinolates via isothiocyanates [20][21][22][23]. Furthermore, even in the case of camalexin biosynthesis, which is mostly independent of the indole glucosinolate pathway, a similar biochemical mechanism involving at least two identical enzymes is utilized to incorporate sulfur into the molecular structure.…”

Section: Origin and Structural Diversity Of Indole Phytoalexinsmentioning

confidence: 99%

Anticancer Potential of Indole Phytoalexins and Their Analogues

Zigová,

Michalková,

Mojžiš

2024

Molecules

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Indole phytoalexins, found in economically significant Cruciferae family plants, are synthesized in response to pathogen attacks or stress, serving as crucial components of plant defense mechanisms against bacterial and fungal infections. Furthermore, recent research indicates that these compounds hold promise for improving human health, particularly in terms of potential anticancer effects that have been observed in various studies. Since our last comprehensive overview in 2016 focusing on the antiproliferative effects of these substances, brassinin and camalexin have been the most extensively studied. This review analyses the multifaceted pharmacological effects of brassinin and camalexin, highlighting their anticancer potential. In this article, we also provide an overview of the antiproliferative activity of new synthetic analogs of indole phytoalexins, which were synthesized and tested at our university with the aim of enhancing efficacy compared to the parent compound.

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Section: Origin and Structural Diversity Of Indole Phytoalexinsmentioning

confidence: 99%