Phytochemical Analysis and Antimicrobial Activity of Neocaryamacrophylla Leaves Extract

Isaka, Ibrahim; Gumel, Ahmad Mohammed; Muhammad, Humaira Ya’u; Kemi, Amoo Florence

doi:10.20319/lijhls.2017.31.1834

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…The frequency of lifethreatening infections caused by pathogenic microorganisms has increased worldwide and is becoming an important cause of morbidity and mortality especially in developing countries with lower health status indices. Also, the high prevalence of multi-drug resistant strains of bacteria has elevated the threat of untreatable bacterial infections and adds urgency to the hunt for new healing strategies (Isaka et al, 2017). In addition to this problem, antibiotics are sometimes associated with adverse effects on the host, which include hypersensitivity, depletion of beneficial gut and mucosal microorganism, immune suppression and allergic reactions (Namita & Mukesh, 2012).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of <i>Phoenix dactylifera</i> (date palm) on some selected members of enterobacteriaceae

Sani¹,

Abdulkadir²,

Mujahid³

2018

Bayero J. Pure App. Sci.

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The use of medicinal plants in Africa for therapeutic purpose has been quite a common practice. However, most of these plants are used indiscriminately without proper knowledge of their chemical constituents, spectrum of activity, inhibitory or bactericidal concentrations. Moreover, the widespread and often indiscriminate use of antimicrobial drugs has resulted in resistance of microbes to specific antibiotic treatments. In view of this, the antibacterial activity of Phoenix dactylifera was determined using agar well diffusion method. A total of 2.43g and 2.12g of the methanolic extract from the original weight of 25g was recovered from the leaf and fruit of Phoenix dactylifera respectively. The leaf extracts showed greater antibacterial effects against Klebsiella pneumoniae with zones of inhibition measuring 34mm, 28mm, 26mm and 24mm at the concentrations of 40mg/ml, 30mg/ml, 20mg/ml and 10mg/ml while Salmonella typhi had zones of 20mm and 14 mm at 40mg/ml and 30mg/ml. However, the fruit extract inhibited the growth of all the test organisms at varying concentrations with the highest zone recorded against Salmonella typhi (38mm) at 40mg/ml. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) analysis also confirmed the antibacterial effect of these extracts. Phytochemical analysis also showed the presence of Saponins, Tannins, Alkaloids, Steroids, Phenols and Flavonoids. The findings of this research suggest that infection by members of Enterobacteriaceae can be treated using Phoenix dactylifera fruit and leaves as an alternative to conventional antibiotics.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of <i>Phoenix dactylifera</i> (date palm) on some selected members of enterobacteriaceae

Sani¹,

Abdulkadir²,

Mujahid³

2018

Bayero J. Pure App. Sci.

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“…The study was inspired by the widespread ethnomedicinal use of the plant N. macrophylla in the management of snakebite, microbial infections, pain, and anti-inflammatory diseases. Preliminary results provided promising results and validated the ethnomedicinal claims [25] . Inspired by these results, the ethylacetate soluble fraction of the methanol stem bark extract which appeared to be promising was subjected to chromatographic studies in order to isolate and evaluate bioactive compound(s) responsible for the observed antivenom, analgesic, antiinflammatory, and antimicrobial effects.…”

Section: Discussionmentioning

confidence: 56%

“…GC-MS analysis of the chloroform leaf extract of N. macrophylla revealed the presence of flavonoids, steroids, palmitoleic acid, tannins, glycosides, alpha and beta tacopherol [25]. Pharmacological actions of the stem bark of N. macrophylla has been confined to analgesic [23], antimicrobial [24] and antivenom [25] activities; Isaka et al [25] has reported the antimicrobial activity of the ethanol leaf extract of the plant; the extracts and fractions of N. macrophylla leaf exhibited remarkable antibacterial and antibiofilm activities against S. aureus and P. aeruginosa [26]. Antimicrobial activity of stigmasterol from the stem bark of the plant has also been reported [27].…”

Section: Introductionmentioning

confidence: 99%

Bioactive (+)-Catechin-3ꞌ-O-rhamnopyranoside from Neocarya macrophylla (Sabine) Prance (Chrysobalanaceae)

Yusuf

Abdullahi

Musa

et al. 2019

Egyptian Journal of Basic and Applied Sciences

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In this study, a flavan-3-ol glycoside, (+)-catechin-3ꞌ-O-rhamnopyranoside isolated from the stem bark extract of N. macrophylla was evaluated for its antivenom, analgesic, anti-inflammatory, and antimicrobial activities. The compound (at 1, 5 and 10 mg/kg) was able to protect mice against lethality induced by Naja nigricollis venom with 100%, 40%, and 20% survival rate, respectively; it was also found to be 33.7% effective in combating the hydrolytic actions of N. nigricollis PLA 2 enzyme; the compound (at 2.5 and 10 mg/kg) exhibited significant (p < 0.05) analgesic effect in the formalin test which was higher than that observed by the standard drug, piroxicam (10 mg/kg) and there was 45.0% and 41.2% inhibition of inflammation by the compound at the 3rd & 4th hours. In addition, the compound was found to be effective against S. aureus, VRE, S. feacalis, E. coli, P. aeruginosa, P. vulgaris, C. albicans, and C. krusei with mean zone of inhibition ranged between 28 and 36 mm and an MIC and MBC/MFC values ranging from 6.25 to 25.0 µg/mL and 12.5-50.0 µg/mL, respectively. Thus, bioactivities of (+)catechin-3ꞌ-O-rhamnopyranoside were reported for the first time.

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“…Nm seed cake contains tannins, flavonoids and alkaloids [17]. Carbohydrates, alkaloids, flavonoids, anthraquinones tannins, saponins, glycosides, steroids and triterpenes were reported to be present in the methanol stem bark extract of Nm [37].…”

Section: Flavonoidsmentioning

confidence: 99%

“…The methanol stem bark extract of Nm showed good antimicrobial effect against some clinical isolates including S. pyogenes, S. feacalis, B. subtilis, B. cereus, E. coli, P. fluorescence, C. albicans and C. krusei with MIC and MBC/MFC values ranging from 2.5 -5.0 mg/mL and 5 -20 mg/mL, respectively [37]. Moreover, stigmasterol from the stem bark of Nm exhibited a broad-spectrum antimicrobial activity against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), S. aureus, S. faecalis, E. coli, S. typhimurium, P. fluorescens, K. pneumoniae, C. albicans and C. krusei with MIC and MBC/MFC values ranging from 6.25 -25 μg/mL and 12.5 -50 μg/mL, respectively [41].…”

Section: Biological and Pharmacological Properties Of Nmmentioning

confidence: 99%

Neocarya macrophylla (Sabine) Prance: Review on Taxonomy, Ethnobotany, Phytochemistry and Biological Activities

Yusuf¹,

Mi²,

Aa³

et al. 2021

Preprint

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Neocarya macrophylla (Sabine) Prance (Nm, Chrysobalanaceae) is used traditionally as food, for medicinal spiritual and industrial purposes. It is also used as soap, dye, glue, fodder, termite repellent, firewood and for structural materials. Few studies on the physicochemical, nutritional contents, phytochemical and pharmacological activities have validated the benefits of Nm to humanity as food, in cosmetics and pharmaceutical products. The major bioactive constituents identified in the plant so far are steroids and flavonoids (such as stigmasterol, quercetin, catechin and its related glycosides). Extracts of the plant have shown good antivenom, antimicrobial, analgesic, anti-inflammatory, antimycobacterial, anthelmintic and antioxidant activities. Acute toxicity studies conducted have confirmed the plant to be toxic. More studies on the plant are required in order to exploit other biological activities as claimed by traditional healers and also to isolate more bioactive compounds. In addition, the safety and tolerability assessment of Nm should be undertaken due to its widespread usage.

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Phytochemical Analysis and Antimicrobial Activity of Neocaryamacrophylla Leaves Extract

Abstract: Abstract

Cited by 7 publications

References 6 publications

Antimicrobial activity of <i>Phoenix dactylifera</i> (date palm) on some selected members of enterobacteriaceae

Antimicrobial activity of <i>Phoenix dactylifera</i> (date palm) on some selected members of enterobacteriaceae

Bioactive (+)-Catechin-3ꞌ-O-rhamnopyranoside from Neocarya macrophylla (Sabine) Prance (Chrysobalanaceae)

Neocarya macrophylla (Sabine) Prance: Review on Taxonomy, Ethnobotany, Phytochemistry and Biological Activities

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