Phytochemical analysis and antioxidant activity of methanol extract and betulinic acid isolated from the roots of Tetracera potatoria

Adesanwo, Julius K.; Makinde, Oluwatoyin O.; Obafemi, Craig A.

doi:10.1016/j.jopr.2013.09.003

Cited by 28 publications

(31 citation statements)

References 10 publications

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“…Details of the crystal data are presented in Table 1. The identification of the other two major constituents as betulinic acid (2) and eriodictyol (3) was based on comparison of spectroscopic data (UV, IR, NMR and MS) with those published before [11,12] and authentic samples.…”

Section: Resultsmentioning

confidence: 99%

Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.)

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.)

et al. 2015

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“…The potency of these redox active metals can be reduced by electron donation and phytochemicals have been shown to perform such tasks. The donation of electrons by the phytochemicals (especially polyphenols) prevents the radical chain reactions which specifically damage membrane lipids, proteins and DNA [27].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant evaluation and inhibitory activity of Chromolaena odorata leaf extract on hydrogen peroxide-induced erythrocyte hemolysis

Nwachukwu¹,

Iyagbo²,

Onyenweaku³

et al. 2018

Am J Res Med Sci

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Aim: Chromolaena odorata has been used traditionally for the treatment of various conditions which include skin infections, wounds, ulcers and also used as an antimalarial. The present work investigates the ability of the methanolic extract of the plant to inhibit hydrogen-peroxide induced haemolysis and lipid peroxidation of human erythrocytes. Other in vitro antioxidant and free radical scavenging activities were also investigated. Materials and Methods: Dried leaves of Chromolaena odorata were pulverized and extracted using absolute methanol. Venous blood was collected from a healthy individual and erythrocytes isolated. Erythrocyte haemolysis and lipid peroxidation were induced using hydrogen peroxide and subsequently treated with Chromolaena odorata extract. The plant extract was also assessed for its hydrogen peroxide scavenging, hydroxyl radical scavenging and reducing abilities. In all cases, vitamin C was used as the reference compound. Results:The results show that Chromolaena odorata extract reduced hydrogen peroxide-induced haemolysis and lipid peroxidation when compared to vitamin C. While the IC 50 values for the extract were 4.11 mg/mL and 12.95 mg/mL for inhibition of erythrocyte haemolysis and lipid peroxidation respectively, the IC 50 values for vitamin C were 1.98 mg/mL and 0.57 mg/mL for haemolysis and lipid peroxidation. The extract also possessed hydrogen peroxide scavenging, hydroxyl radical scavenging and reducing abilities. In most cases, the effects were concentration-dependent and significant among various extracts concentrations (p < 0.05). Conclusion:The observed responses indicate that the plant possessed immense antioxidant potential which could be ascribed to the bioactive phytochemicals. This could be exploited pharmacologically. ARTICLE HISTORY

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“…Kajian sebelumnya menjelaskan asam betulinik sebagai senyawa mayor yang dihasilkan oleh tanaman songi (Jalil et al, 2015;Sabandar et al, 2017). Asam betulinik menunjukkan aktivitas penangkapan radikal bebas yang lemah (Adesanwo et al, 2013)…”

Section: Aktivitas Antioksidanunclassified

Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.)

Sabandar¹,

Jalil

Ahmat

et al. 2020

JFG

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Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol>ethyl acetate>petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature.

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Phytochemical analysis and antioxidant activity of methanol extract and betulinic acid isolated from the roots of Tetracera potatoria

Cited by 28 publications

References 10 publications

Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.)

Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.)

Antioxidant evaluation and inhibitory activity of Chromolaena odorata leaf extract on hydrogen peroxide-induced erythrocyte hemolysis

Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.)

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