Phytochemical analysis and evaluation of purified extract of Tinospora crispa stem for in vivo antihyperuricemic effect

Harwoko, Harwoko; Warsinah, Warsinah

doi:10.4103/jrptps.jrptps_45_19

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…The extract reduced the levels of uric acid ranging from 49 to 78% at doses of 50–200 mg/kg. Peak activity was observed at the 100 mg/kg dose compared to the standard allopurinol (10 mg/kg) (Harwoko and Warsinah 2020 ) (Fig. 11 ).…”

Section: Pharmacological Activitymentioning

confidence: 99%

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson

et al. 2022

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Tinospora crispa (L.) Hook. f. & Thomson (Menispermaceae) is a plant indigenous to Africa and South-East Asia. It is widely used in ethnomedicine to alleviate various diseases including hypertension, diabetes, rheumatism, jaundice, inflammation, fever, fractures, scabies, and urinary disorders. A total of 167 phytoconstituents, belonging to 12 different chemical categories, including alkaloids, flavonoids, terpenoids, and phenolic compounds have thus far been isolated from various parts of T. crispa. Numerous in vitro and in vivo investigations have already established the antidiabetic, anticancer, antiparasitic, antimicrobial, immunomodulatory, hepatoprotective, analgesic, antipyretic, antihyperuricemic, and pesticidal activity of this plant, as well as its effects on the cardiac and the central nervous system. Most pharmacological investigations to date have been carried out on plant extracts and fractions. The exact identity of the phytoconstituents responsible for the observed biological effects and their mode of action at the molecular level are yet to be ascertained. Toxicological studies have demonstrated that T. crispa is relatively safe, although dose-dependent hepatotoxicity is a concern at high doses. This review presents a comprehensive update and analysis on studies related to the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of T. crispa. It provides some critical insights into the current scientific knowledge on this plant and its future potential in pharmaceutical research.

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Section: Pharmacological Activitymentioning

confidence: 99%

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson

et al. 2022

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“… Clerodane derivatives [(5R,10R)-4R-8Rdi-hydroxy-2S-3R: 15, 16- diepoxy-cleroda-13 T. crispa 52. Apigenin Flavonoids Stem Cardio-protective [ 67 ] 53. Diosmetin 54.…”

Section: Chemical Compositionmentioning

confidence: 99%

Indian herb Tinospora cordifolia and Tinospora species: Phytochemical and therapeutic application

Chaudhary,

Das,

Mehta

et al. 2024

Heliyon

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“…Kết quả định tính của cao chiết thân dây cóc bằng phương pháp hóa học cho thấy, cao chiết thân dây cóc có chứa các hợp chất như alkaloid, flavonoid, saponin, steroid, terpenoid, tannin và phenol (Bảng 2). Kết quả tương tự nghiên cứu của Sensen [13], Harwoko and Warsinah [14]. Cả hai công trình này đều cho rằng, dịch trích thân dây cóc có chứa các hợp chất có hoạt tính sinh học như alkaloid, flavonoid, saponin, steroid, terpenoid, tannin và phenol.…”

Section: B địNh Tính Một Số Hợp Chất Sinh Học Có Trong Cao Chiết Thân Dây Cócunclassified

BIOACTIVE COMPOUNDS ANALYSIS AND ANTIOXIDANT ACTIVITIES OF Tinospora crispa MIERS STEM EXTRACT

Nguyen¹,

Bang²,

Nguyen³

et al. 2020

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The study was conducted to analyze some of the bioactive compounds and the antioxidant capacity of Tinospora crispa stem extract. Tinospora crispa stem extract is a prerequisite for the production of products capable of supporting and treating diseases. Tinospora crispa stem extract is made by immersion method withsolvents (water, ethanol 80o and methanol) and combined with ultrasound. Antioxidant activities were tested using DPPHmethods and phenolic, flavonoid, polysaccharide, tannin content were determined by the spectrophotometer method. The results showed that the moisture content was 61.09% and high extraction efficiency of Tinospora crispa stem were between 3.69% and 6.95% respectively. The extract of Tinospora crispa stem contains the presence of biological compounds such as alkaloids, flavonoids, saponin, steroids, tannins and phenols. The phenolic, flavonoid, polysaccharide and tannin content of Tinospora crispa stem were318.91 mg gallic acid/g dry; 36.71 mg quercetin/g dry; 10.38 mg GE/g dry and 38.42 mg tannic acid/g dry respectively. Tinospora crispa stem has antioxidant ability by DPPH method with IC50 value of water, ethanol 80o and methanol 113.69 mg/mg; 89.12 mg/mg; 62.19 mg/mg, respectively. Thus, the Tinospora crispastem extract had bioactive compounds and antioxidant activities, is a potential source of raw materials for research and applications.

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Phytochemical analysis and evaluation of purified extract of Tinospora crispa stem for in vivo antihyperuricemic effect

Cited by 7 publications

References 1 publication

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson

Indian herb Tinospora cordifolia and Tinospora species: Phytochemical and therapeutic application

BIOACTIVE COMPOUNDS ANALYSIS AND ANTIOXIDANT ACTIVITIES OF Tinospora crispa MIERS STEM EXTRACT

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