Phytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae)

Fasina, Folorunso Oludayo; Olaokun, Oyinlola Oluwunmi; Oladipo, Olusola O.; Fasina, Margaret M.; Makinde, A. A.; Heath, Livio; Bastos, Armanda D.S.

doi:10.1186/1746-6148-9-120

Cited by 8 publications

(6 citation statements)

References 46 publications

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“…Due to the lack of information on plant extracts and their virucidal effectiveness against ASFV [32,33], the aim of the present study, was to determine the virucidal activity of fourteen selected plant extracts (Table 1), based on the method inspired by the PN-EN 14675:2015 European Standard. Neither of the available studies have proven the effectiveness of the examined extracts.…”

Section: Discussionmentioning

confidence: 99%

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Virucidal Activity of Plant Extracts against African Swine Fever Virus

et al. 2021

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African swine fever is one of the most dangerous and fatal swine diseases, described for the first time roughly a hundred years ago. Even now, there is neither a commercially approved vaccine nor treatment available. The only way to hinder further spread of the disease is by culling the affected herds and applying prevention based mainly on proper biosecurity. Due togrowing awareness of the potential ASF threat among pig producers, disinfection processes are considered as one of the most important preventive measures. Currently, a variety of chemical compounds are applied for the disinfection of pig farms. Meanwhile, these chemicals may pose a potential risk, due to their toxic, irritant or corrosive effect. The aim of this study was to determine whether any plant-based natural compounds may show a virucidal effect against ASFV, and simultaneously be depleted of some of the side-effects typical for chemical compounds. Ideally, natural virucidal compounds should be safe for both humans and animals, biodegradable, easily available and inexpensive. Fourteen plant extracts were selected and screened for their virucidal effect against ASFV, using the suspension test inspired by the PN-EN 14675:2015 European Standard procedure. The results of our study showed that most of the tested plant extracts were ineffective against ASFV. Some extracts suspended in a hydroglycolic medium exhibited high virus titre reduction, but it was confirmed that the effect resulted from medium composition. However, a 1.05% peppermint extract showed high effectiveness against ASFV, reducing the virus titre by ≥4 log10, thus demonstrating that natural compounds used as virucidal agents could potentially be used in disinfection procedures, being both effective and harmless to humans and animals.

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Section: Discussionmentioning

confidence: 99%

“…Due to the lack of information on the testing of plant extracts against ASFV [32,33], the aim of the present study was the determination of the antiviral activity of fourteen oil, hydroglycerin or hydroglycolic plant extracts (Table 1), using a method based on the PN-EN 14675:2015 European Standard.…”

Section: Introductionmentioning

confidence: 99%

Virucidal Activity of Plant Extracts against African Swine Fever Virus

et al. 2021

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“…EVM has also been used for specific viral diseases, e.g. Rabies, Bovine herpesvirus-1, Rotavirus, Bovine viral diarrhoea (Zitterl-Eglseer and Marschik, 2020), Foot and mouth disease (Kpodékon et al 2015), African swine fever (Fasina et al 2013), Infectious bursal disease (Ganguly et al 2020), and Porcine reproductive and respiratory syndrome (Kaewprom et al 2015).…”

Section: What Is Evmmentioning

confidence: 99%

Ethnoveterinary medicine for responsible dairying

Rath

Sharma

Joshi

2020

IJDS

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“…Ancistrocladus uncinatus [29] 42. riboflavin Hibiscus rosasinensis [30] 43. Xanthotoxol Syzygium caryophyllatum [27] 44.…”

Section: -Fluorononaneunclassified

Molecular Docking, ADMET Analysis and Dynamics Approach to Potent Natural Inhibitors against Sex Hormone Binding Globulin in Male Infertility

Esther¹,

Vijayakumar²,

Kumar³

et al. 2017

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Objectives:The Sex Hormone Binding Globulin (SHBG) plays an important role in male infertility. Methods: The present research computationally emphases to SHBG protein with 47 natural phytocompounds using docking studies. Results: From the results showed the interactions between 1KDM protein with 47 phytocompounds, a natural compound chlorogenic acid showed the best glide docking XP score -7.255 kcal/mol and the binding energy value of -47.869 kcal/ mol. Based on the result, the chlorogenic acid and target were run on MD simulations stable at 10 ns. Conclusion: Finally, this study concludes the chlorogenic acid is a suitable drug candidate for infertility.

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Phytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae)

Cited by 8 publications

References 46 publications

Virucidal Activity of Plant Extracts against African Swine Fever Virus

Virucidal Activity of Plant Extracts against African Swine Fever Virus

Ethnoveterinary medicine for responsible dairying

Molecular Docking, ADMET Analysis and Dynamics Approach to Potent Natural Inhibitors against Sex Hormone Binding Globulin in Male Infertility

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