Phytochemical analysis, antioxidant and anti-inflammatory activities of Helichrysum stoechas (L.) Moench extracts

Kherbache, Abdallah; Senator, Abderrahmane; Laouicha, Saliha; Al‐Zoubi, Raed M.; Bouriche, Hamama

doi:10.1016/j.bcab.2020.101826

Cited by 15 publications

(9 citation statements)

References 35 publications

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“…The activity of Raphia farinifera shell and kernel extracts depends on their concentration. These results are in line with several studies [43][44][45] which also found that the protective activity of plant extracts against protein denaturation was dependent on extract concentration. The disruption of electrostatic and hydrogen bonds and disulphide bridges, which enable the secondary and tertiary structures of proteins to be maintained, associated with the production of self-antigens, is often attributed to protein denaturation in certain arthritic diseases [43,46].…”

Section: Antimicrobial Activity Of Ethanolic Extracts Of Shells Andsupporting

confidence: 92%

Face-Centered Central Composite Design for the Optimization of the Extraction of Phenolic Compounds from Kernels and Shells of Raphia farinifera and Evaluation of the Antioxidant, Antimicrobial, and Anti-Inflammatory Activities

Kouteu,

Kemegne,

Pahane

et al. 2024

Journal of Food Processing and Preservation

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This study reports the extraction of phenolic compound from shells and kernels of the Raphia farinifera fruit and the biological activities of the extract. A face-centered composite design was established to optimize the extraction conditions: ethanol/water ratio (0-100%), solvent/powder ratio (10-30 mL/g), and extraction time (90-180 min). Subsequently, the extracts obtained under the optimal conditions were used for the evaluation of the radical scavenging capacity, the capacity to chelate ferric ions, and the antimicrobial and anti-inflammatory activities. The optimal extraction conditions for the shells are an extraction time of 134.24 min, 65% ethanol in water, and a solvent/substrate ratio of 21.16 mL/g, and for the kernel, an extraction time of 180 min, 94.3% ethanol in water, and a solvent/substrate ratio of 18.6 mL/g. In these conditions, the phenolic compounds were 95.36 mg EAG/L for the shell extract and 139.72 mg EAG/L for the kernel extract. The antioxidant activity revealed that the half-maximal inhibitory concentrations (IC50) of the kernel extracts are 22.32 μg/mL and 55.73 μg/mL for the shells. A reducing activity of Fe 3+ ions with an activity of 308.39 μg EAA/mg for the kernel extracts and 293 μg EAA/mg for the shells was observed. B. cereus was the most sensitive microorganism with a minimum inhibitory concentration (MIC) equal to the minimum bactericidal concentration (MBC) with a value of 156.25 ppm for the kernel extract while the shell extract showed MIC of 625 ppm and MBC of 2500 ppm. The IC50 values for the denaturation of proteins by extracts of shells and kernels are 0.76 μg/mL and 0.56 μg/mL, respectively. Membrane stabilization revealed IC50 values of 1054.54 μg/mL and 1339 μg/mL for the shell and kernel extracts, respectively. This work has shown the potential of Raphia farinifera extracts for the food industry and cosmetics.

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Section: Antimicrobial Activity Of Ethanolic Extracts Of Shells Andsupporting

confidence: 92%

Face-Centered Central Composite Design for the Optimization of the Extraction of Phenolic Compounds from Kernels and Shells of Raphia farinifera and Evaluation of the Antioxidant, Antimicrobial, and Anti-Inflammatory Activities

Kouteu,

Kemegne,

Pahane

et al. 2024

Journal of Food Processing and Preservation

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“…Flavonoids are natural products widely found in the plant kingdom and are currently consumed in large amounts in the daily diet (Augðpole et al, 2018). Rutin has a wide range of bioactivity including antioxidant and anti-inflammatory, and therefore researchers are searching for its potential sources (Camponogara et al, 2020;Kherbache et al, 2020). The results of the current study confirm that leaves of bear's garlic can be a potential source of rutin.…”

Section: Discussionsupporting

confidence: 69%

Evaluation of the Phenolic Profile of Bear’s Garlic (Allium Ursinum L.) Leaves

Cinkmanis

Augspole

Sivicka

2022

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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European wild garlic (Allium ursinum L.) syn. wood garlic, ramsons or bear’s garlic is a perennial plant that is common in Europe and Asia, but rare in the Mediterranean region. Bear’s garlic is included in the Latvian Red Data Book. The plant species has high commercial value and a high amount of biologically active compounds. Because of the conservation status of wild populations, raw material should be obtained by cultivation. For the experiment, leaves of six accessions of bear’s garlic from the ex situ collection of medicinal and aromatic plants at the Latvia University of Life Sciences and Technologies, were used. The aim of this study was to identify the individual phenolic compounds in bear‘s garlic leaves. The composition of the phenolic profile was determined using a high-performance liquid chromatograph (HPLC) Shimadzu Nexera LC-40 with diode-array detector (DAD). Overall, 18 phenolic compounds (gallic acid, 3.5-diOHbenzoic acid, catechin, chlorogenic acid, 4-hydroxybenzoic acid, epicatechin, homovanillic acid, caffeic acid, vanillic acid, syringic acid, vanillin, p-coumaric acid, rutin, sinapic acid, ferulic acid, 2-OHcinnamic acid, quercetin, luteolin, and kaempferol) were detected in the samples. The gallic acid was the predominant phenolic compound, with a range in concentration from 75.8 mg·100 g−1 to 322.5 mg·100 g−1 in bear’s garlic.

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“…In contrast to Helichrysum italicum, which has been extensively studied [1], only a few studies were conducted on H. stoechas [2]. They showed interesting biological activities of methanolic extracts from flowering aerial parts towards cosmetic [3] and pharmaceutical [4] applications, as well as in the food industry because of its antimicrobial potential and strong antioxidant capacity [5][6][7]. Recent data showed that powder or extract of H. stoechas had antifungal activity against plant pathogenic fungus Sclerotinia sclerotiurum, opening new perspectives in the field of agro ecology [8].…”

Section: Introductionmentioning

confidence: 99%

Methyl Jasmonate Elicited Helichrysum stoechas (L.) Moench Cell Suspensions, A Promising Source of Extracts with Allelopathic Activity?

Gourguillon

Rustenholz²,

Gélébart³

et al. 2021

JOJHA

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Helichrysum stoechas (L.) Moench cell suspensions were analyzed by LC-ESI-QTOF, which highlighted the predominance of 3,5-O-dicaffeoylquinic acid (3,5-diCQA). Elicitation of H. stoechas cells with methyl jasmonate (200 mM) led to a massive rise in 3,5-diCQA, up to 5-fold-increase compared with control, reaching the concentration of 10.2 mg. g-1dry weight after 14 days of culture. Previous data showed that diCQA isomers are potent allelopathic compounds, thus the methanolic extracts of control and MeJa-elicited H. stoechas cells were tested for their phytotoxicity. With this in mind, activity on the seed germination and seedling growth of the model plant Lepidium sativum were tested. Phytotoxicity of both extracts occurred in a dose-dependent manner, with a greater activity of elicited cells extract. Indeed, in the concentration range from 0.31 to 0.83 mg. mL-1, the latter showed a significantly higher inhibition rate of L. sativum seedlings root growth, when compared to control cells extract. The data presented may contribute to explore new strategies towards the conception of bioherbicides from plant origin. To our knowledge, this study is the first report of the use of elicited plant cells grown in vitro as a raw material for the production of allelopathic metabolites.

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Phytochemical analysis, antioxidant and anti-inflammatory activities of Helichrysum stoechas (L.) Moench extracts

Cited by 15 publications

References 35 publications

Face-Centered Central Composite Design for the Optimization of the Extraction of Phenolic Compounds from Kernels and Shells of Raphia farinifera and Evaluation of the Antioxidant, Antimicrobial, and Anti-Inflammatory Activities

Face-Centered Central Composite Design for the Optimization of the Extraction of Phenolic Compounds from Kernels and Shells of Raphia farinifera and Evaluation of the Antioxidant, Antimicrobial, and Anti-Inflammatory Activities

Evaluation of the Phenolic Profile of Bear’s Garlic (Allium Ursinum L.) Leaves

Methyl Jasmonate Elicited Helichrysum stoechas (L.) Moench Cell Suspensions, A Promising Source of Extracts with Allelopathic Activity?

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