Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts

Boğa, Mehmet; Ertaş, Abdülselam; Özkan, Esra Eroğlu; Kızıl, Murat; Çeken, Bircan; Topcu, Gülaçtı

doi:10.1016/j.sajb.2016.02.204

Cited by 29 publications

(22 citation statements)

References 30 publications

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“…Total phenolic content of the ethanol and water extracts of A. macrocheatum bulb and aerial parts was expressed as micrograms of pyrocatechol equivalents (PEs) (Boğa et al, ). Total phenolic content was calculated according to the following equation:

`` Absorbance = 0.047 pyrocatechol false(normalμ g false) + 0.0413'' (R^{2} = 0.9954)

…”

Section: Methodsmentioning

confidence: 99%

“…The DPPH free radical (Boğa et al, ), ABTS cation radical scavenging activities (Re et al, ), and cupric reducing antioxidant capacity (CUPRAC) (Apak, Guclu, Ozyurek, & Karademir, methods were used to determine antioxidant activities of the ethanol and water extracts of A. macrocheatum bulb and aerial parts.…”

Section: Methodsmentioning

confidence: 99%

“…The DPPH free radical (Boğa et al, 2016), ABTS cation radical scavenging activities (Re et al, 1999), and cupric reducing anti-…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

et al. 2019

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The study was aimed to investigate the phenolic compounds of Allium macrochaetum by LC‐MS/MS, as well as the antioxidant, antialzheimer, and antimicrobial activities of the extracts, and determination of the essential oil and fatty acid compositions by GC‐MS. The results indicate that malic acid and t‐caffeic acid are the major compounds in the bulbs. The main components of fatty acids were found to be linolenic (40.72%), oleic (19.79%), and palmitic (18.45%) acids. The allyl disulfide (66.97%) was found as major compound in the essential oil. The ethanol extract of the bulbs exhibited stronger ABTS cation (IC50: 55.90 ± 1.08 µg/ml) and DPPH free (IC50: 204.43 ± 2.17 µg/ml) radical scavenging activities than the other extracts. The extract also showed moderate cupric reducing activity with 1.52 absorbance at 100 µg/ml concentration. Only the ethanol extract of the bulbs showed weak inhibition (23.34 ± 0.11%) against butrylcholinesterase enzyme at 200 µg/ml. Practical applications Allium macrochaetum is a wild and edible garlic species which grown in Turkey, Iran, Iraqi, and Syria. A. macrochaetum has been used by local people in Turkish folk medicine as an antibiotic, and for the treatment of alopecia. The health benefits and nutritional values of A. macrochaetum were clarified in the first time. Phenolic compounds of A. macrochaetum were detected by LC‐MS/MS. The essential oil and fatty acid compositions of A. macrochaetum were identified by GC‐MS. Antioxidant, antialzheimer, and antimicrobial activities potential of A. macrochaetum were determined.

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`` Absorbance = 0.047 pyrocatechol false(normalμ g false) + 0.0413'' (R^{2} = 0.9954)

…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

et al. 2019

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“…The Hypericum spp. have been regarded as having various medicinal effects like antidepressant, antiseptic, antispasmodic and antimicrobial, and were used for a very long time in external wounds healing and gastric diseases [2]. In folk medicine H. perforatum , also called St. John’s Wort, is one of the best known representative of the Hypericum genus, and it was believed to cure ulcerated burns, gastric and urogenital infections and others [3].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the extracts of the plant exhibited a slight antiretroviral activity towards HIV-I [5]. In vitro antioxidant capacity [2] analysis of H. capitatum var. capitatum extracts, in various solvents, recommend this plant as a natural source of free radical scavengers.…”

Section: Introductionmentioning

confidence: 99%

Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats

Fărcăş

Moţ

Zagrean-Tuza

et al. 2019

BMC Complement Altern Med

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BackgroundNatural extracts with beneficial biological activities are nowadays of high interest, in various treatment or prophylaxis. Hypericum capitatum has been known for its curative effects for centuries and its extracts have become of interest due to their distinct activity among other Hypericaceae members. In this study, further light is aimed to be shed on the secondary-metabolites composition of H. capitatum extracts, using chromatographic techniques and Electron paramagnetic resonance profiles in alkaline medium. Considering that no previous works explored the anti-inflammatory activity of H. capitatum, here, an in vivo study is also designed in order to evaluate this property by assessing the impact of one of H. capitatum extracts in ameliorating turpentine oil-induced inflammation on rats and to quantify their blood antioxidants level.MethodsChromatographic techniques and Electron paramagnetic resonance spectroscopy were used in order to describe the chemical profile in different parts of the plant. The in vivo study on turpentine-oil induced inflammation in rats included three doses of H. capitatum extract expressed in rutin concentration. Oxidative stress was measured using total oxidative status, total antioxidant capacity, oxidative stress index, 3-nitrotyrosine, nitric oxide, malondialdehyde, superoxide dismutase, catalase and the inflammatory response was evaluated by performing a complete blood cells count and C reactive protein.ResultsThe extract was remarkably rich in rutin; however, other polyphenolic-like minor components appeared important in explaining the observed biological properties. The tested extract prevents the increase of inflammation-induced white blood cell count, number of neutrophils, and serum nitric oxide, and did so in a dose-dependent manner, similarly to the positive control—diclofenac. In addition, the same extract appeared to be a good alternative to diclofenac to restore total oxidative status, thiobarbituric active reactive species, total proteins and C reactive proteins. Moreover, antioxidant enzymes such as catalase, superoxide dismutase and total serum thiol concentration were significantly increased by the tested extract.ConclusionsDue to its powerful reservoir rich in rutin, H. capitatum extract depicted its in vivo antioxidant and anti-inflammatory effects indicating it to be a good alternative to conventional drugs for oxidative stress protection.

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Phenolic Compound Contents of Hypericum Species from Turkey

Asan

2020

Propagation and Genetic Manipulation of Plants

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Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts

Cited by 29 publications

References 30 publications

Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats

Phenolic Compound Contents of Hypericum Species from Turkey

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