Phytochemical analysis, antiproliferative and apoptosis-inducing properties of Persicaria strigosa Nakai

Abstract

Persicaria strigosa is an important medicinal plant having several ethnomedicinal values. This study investigated the phytochemical contents, antiproliferative, and apoptosis-inducing properties of P. strigosa. The phytocompounds were identified by the Gas Chromatography Mass Spectrometry (GC-MS) technique. Antiproliferative and apoptosisinducing properties were conducted in Dalton's lymphoma cells. In-silico molecular docking, drug-likeness, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) were carried out to study the binding affinity and drug-likeness of the compounds. The study revealed a dose-dependent antiproliferative activity of the plant. GC-MS study identified 12 compounds from the ethyl acetate extract. Phytompounds C2, C5, C6, C7, and C12 showed the best binding affinity with the anti-apoptotic proteins. The phytocompounds were predicted to possess drug-likeness properties and a good ADMET profile. The findings suggest that P. strigosa could be a potential source of anticancer agents.