Phytochemical analysis, cytotoxic, antioxidant and anti-diabetic activities of the aerial parts of Sorghum halepense

Shah, Muhammad Abdur Rehman; Khan, Rahmat Ali; Ahmed, Mushtaq

doi:10.3329/bjp.v14i3.40292

Cited by 7 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, flavonoids prevent oxidative stress development by inhibiting enzymes producing free radicals. 34 The outcome of this research has further verified the increases in plasma TG, TC, VLDL, and LDL, and the decrease in HDL indicated significant dyslipidemia in DC rats.…”

Section: Discussionsupporting

confidence: 57%

Antidiabetic, Antihyperlipidemic, Antioxidant Effects and Regulation of miRNA Expression byDianthus orientalisAdams Extract in Diabetic rat Model

Ahmed,

Rahman,

Mohammed Raheem

et al. 2024

Natural Product Communications

View full text Add to dashboard Cite

Background: The Mediterranean area is a diversity center for the genus Dianthus. However, species belonging to this genus, including Dianthus orientalis Adams (DOA), have not been investigated for their medicinal activities. Objectives: To investigate antidiabetic, antihyperlipidemic, antioxidant effects and molecular mechanism of D. orientalis Adams leaf extract (DOAE) in an animal model. Materials and methods: The plant leaves were collected from July to August 2021 from Penjween district, Sulaimaniyah, Iraq and then identified, authenticated, shadow-dried, and extracted using pure methanol. Thirty rats were divided randomly into 5 groups of 6 animals each. Group 1 was control negative (CN) and received distilled water (DW). Group 2 was diabetic control (DC) that received DW, while group 3 was control positive (CP) treated with Glibenclamide (GLB, 0.6 mg/kg body weight). Groups 4 and 5 were diabetic rats who received a low-dose (30 mg/kg) and a high-dose (90 mg/kg) of DOAE orally for 4 weeks. Then, lipid profile, total antioxidant capacity, histopathological examinations, and molecular studies were conducted. Results: DOAE was more effective than GLB in reducing blood glucose, lipid parameters, liver enzymes, and renal function. Micromorphological assay of livers, kidneys, and pancreas revealed significant restoration in diabetic groups treated with DOAE (90 mg/kg) and GLB compared to the DC group. Microribonuclic acid-21 (miR-21) was significantly expressed in DC but markedly lowered in both DOAE groups, while miR-24 and miR-126 were significantly suppressed in DC and expressed in the DOAE-treated groups. Conclusions: DOAE exerted significant antihyperglycemic, anti-dyslipidemic, antioxidant, and hepatorenal protective effects in diabetic rats.

show abstract

Section: Discussionsupporting

confidence: 57%

Antidiabetic, Antihyperlipidemic, Antioxidant Effects and Regulation of miRNA Expression byDianthus orientalisAdams Extract in Diabetic rat Model

Ahmed,

Rahman,

Mohammed Raheem

et al. 2024

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…The TPC of the Andropogon halepensis aqueous leaf extract, determined using the Folin–Ciocalteu method, was 20.83 ± 0.96 mg GAE/g dry extract. Shah et al had previously reported a TPC value of 20.3 ± 1.5 mg GAE/g dry extract for the aerial parts of S. halepense aqueous extract [ 36 ], and Mohammed et al [ 37 ] reported a polyphenol content of 20.78 ± 1.83 mg GAE/g dry extract for an aqueous extract of aerial parts of Beta vulgaris.…”

Section: Resultsmentioning

confidence: 99%

Biocomposite Materials Derived from Andropogon halepensis: Eco-Design and Biophysical Evaluation

Barbinta-Patrascu,

Nichita,

Bita

et al. 2024

Materials

View full text Add to dashboard Cite

This research work presents a “green” strategy of weed valorization for developing silver nanoparticles (AgNPs) with promising interesting applications. Two types of AgNPs were phyto-synthesized using an aqueous leaf extract of the weed Andropogon halepensis L. Phyto-manufacturing of AgNPs was achieved by two bio-reactions, in which the volume ratio of (phyto-extract)/(silver salt solution) was varied. The size and physical stability of Andropogon—AgNPs were evaluated by means of DLS and zeta potential measurements, respectively. The phyto-developed nanoparticles presented good free radicals-scavenging properties (investigated via a chemiluminescence technique) and also urease inhibitory activity (evaluated using the conductometric method). Andropogon—AgNPs could be promising candidates for various bio-applications, such as acting as an antioxidant coating for the development of multifunctional materials. Thus, the Andropogon-derived samples were used to treat spider silk from the spider Pholcus phalangioides, and then, the obtained “green” materials were characterized by spectral (UV-Vis absorption, FTIR ATR, and EDX) and morphological (SEM) analyses. These results could be exploited to design novel bioactive materials with applications in the biomedical field.

show abstract

Effects of processing parameters on green synthesised ZnO nanoparticles using stem extract of Swertia chirayita

Saha

Karthik²,

Sikdar

et al. 2021

Biocatalysis and Agricultural Biotechnology

View full text Add to dashboard Cite

Phytochemical analysis, cytotoxic, antioxidant and anti-diabetic activities of the aerial parts of Sorghum halepense

Cited by 7 publications

References 30 publications

Antidiabetic, Antihyperlipidemic, Antioxidant Effects and Regulation of miRNA Expression byDianthus orientalisAdams Extract in Diabetic rat Model

Antidiabetic, Antihyperlipidemic, Antioxidant Effects and Regulation of miRNA Expression byDianthus orientalisAdams Extract in Diabetic rat Model

Biocomposite Materials Derived from Andropogon halepensis: Eco-Design and Biophysical Evaluation

Effects of processing parameters on green synthesised ZnO nanoparticles using stem extract of Swertia chirayita

Contact Info

Product

Resources

About