Phytochemical and anti‐inflammatory properties of <i>Scurrula ferruginea</i> (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics

Xiang, Hong; Isa, Nurulfiza Mat; Fakurazi, Sharida; Ismail, Intan Safinar

doi:10.1002/pca.2861

Cited by 14 publications

(8 citation statements)

References 37 publications

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“…Watermelon water extract was prepared using the ultrasonication method [ 40 , 41 ]. Powdered biomass (10 g each) was weighed and dissolved in 200 mL Millipore water.…”

Section: Methodsmentioning

confidence: 99%

Metabolite Profiles of Red and Yellow Watermelon (Citrullus lanatus) Cultivars Using a 1H-NMR Metabolomics Approach

et al. 2020

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Watermelon, a widely commercialized fruit, is famous for its thirst-quenching property. The broad range of cultivars, which give rise to distinct color and taste, can be attributed to the differences in their chemical profile, especially that of the carotenoids and volatile compounds. In order to understand this distribution properly, water extracts of red and yellow watermelon pulps with predominantly polar metabolites were subjected to proton nuclear magnetic resonance (1H-NMR) analysis. Deuterium oxide (D2O) and deuterated chloroform (CDCl3) solvents were used to capture both polar and non-polar metabolites from the same sample. Thirty-six metabolites, of which six are carotenoids, were identified from the extracts. The clustering of the compounds was determined using unsupervised principal component analysis (PCA) and further grouping was achieved using supervised orthogonal partial least squares discriminant analysis (OPLS-DA). The presence of lycopene, β-carotene, lutein, and prolycopene in the red watermelon plays an important role in its differentiation from the yellow cultivar. A marked difference in metabolite distribution was observed between the NMR solvents used as evidenced from the PCA model. OPLS-DA and relative quantification of the metabolites, on the other hand, helped in uncovering the discriminating metabolites of the red and yellow watermelon cultivars from the same solvent system.

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“…Watermelon water extract was prepared using the ultrasonication method [ 40 , 41 ]. Powdered biomass (10 g each) was weighed and dissolved in 200 mL Millipore water.…”

Section: Methodsmentioning

confidence: 99%

Metabolite Profiles of Red and Yellow Watermelon (Citrullus lanatus) Cultivars Using a 1H-NMR Metabolomics Approach

et al. 2020

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“…At the same time, parasitic-host interactions influence the metabolites composition, and biological activities too. Several studies have reported divergences in the composition, quantity, and biological activity of the parasitic plant extracts, when the same parasitic species have been collected from different hosts (Bais & Kakkar, 2013;Fozia et al, 2013;Yusuf et al, 2013b;Bais et al, 2014;Ogunmefun et al, 2015;Furuhashi et al, 2016;Hong et al, 2019). Which might be potential resources of antioxidant and antibacterial activities, according to Abbes et al (2014).…”

Section: )mentioning

confidence: 99%

Pharmacological potential of parasitic Angiosperms against microorganisms

Suaza-Gaviria¹,

Vanegas²,

Fonegra³

2023

BLACPMA

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Parasitic habit plants arouse great interest for their extraordinary growth adaptations and produce different secondary metabolites that allow them to survive the extreme conditions in which they develop. This can provide a range of compounds with multiple uses. However, those plants have been poorly explored and there is very little information about their natural compounds, some healing properties attributed to several communities have been scientifically supported. Articles were consulted in databases (Google Scholar, PubMed, Scielo, Science Direct, Scopus) considering the biological activity reported until June 2021. Parasitic plants present mainly antibacterial activity, some species antifungal moderate activity, and to a lesser extent were found reports of antiprotozoal activity. The composition of parasitic plants should continue to be investigated, which could be an alternative to combat various microorganisms that cause diseases, even resistant to traditional medicines.

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“…Hence the influence of the host in specific function as herbal medicine cannot be a negligible factor. The host species significantly affect the chemical constituents and biological activities of S. ferruginea [3][4][5]. The common host plants of the mistletoe of S. ferruginea are Tabebuia pallida and Lagerstroemia speciosa [6].…”

Section: ■ Introductionmentioning

confidence: 99%

“…As far as our literature studies, only one exhibited the isolated compounds from the S. ferruginea plant: three flavonols, such as quercitrin, quercetin, and 4"-O-acetylquercitrin from an unspecified host [12]. Another literature reported the chemical constituents of the crude extract based on the principal component analysis (PCA) method from 1 H-NMR data resulting in some identified compounds, such as quercitrin, 4"-O-acetylquercitrin, catechin, alanine, threonine, valine, leucine, isoleucine, histidine, formic acid, malic acid, succinic acid, citric acid, fumaric acid, acetic acid, gallic acid, chlorogenic acid, and choline [5].…”

Section: ■ Introductionmentioning

confidence: 99%

Antioxidant Flavonoid Glycoside from Leaves of Cacao Mistletoe (<i>Scurrula ferruginea</i> (Jack) Danser)

Efdi

Pratama²,

Itam³

et al. 2022

Indones. J. Chem.

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Scurrula ferruginea (Jack) Danser is a folk medicine to treat several diseases. S. ferruginea is the mistletoe that lives by deriving nutrients from the host. Hence, the host has a significant effect on the biological activities and bioactive components of S. ferruginea. In this study, the leaves of S. ferruginea were macerated by methanol solvent to extract the chemical components and fractionated by hexane and ethyl acetate solvent, respectively, to separate organic compounds. The biological activity of crude extracts as the antioxidant was investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The result showed that the highest antioxidant activity was obtained from the ethyl acetate fraction with the IC50 of 10.88 ± 0.39 µg/mL. Furthermore, the trituration method used several solvents to isolate secondary metabolites from the initial crude methanol extract. This purification process produced a flavonoid compound of quercitrin. The antioxidant activity of quercitrin was also determined by the DPPH method. The result showed that this compound has stronger activity than the crude extracts with the IC50 of 5.95 ± 0.11 µg/mL. This study demonstrated that cacao mistletoe of S. ferruginea may have the potential activity to treat the diseases caused by the presence of free radicals.

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Phytochemical and anti‐inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics

Cited by 14 publications

References 37 publications

Metabolite Profiles of Red and Yellow Watermelon (Citrullus lanatus) Cultivars Using a 1H-NMR Metabolomics Approach

Metabolite Profiles of Red and Yellow Watermelon (Citrullus lanatus) Cultivars Using a 1H-NMR Metabolomics Approach

Pharmacological potential of parasitic Angiosperms against microorganisms

Antioxidant Flavonoid Glycoside from Leaves of Cacao Mistletoe (<i>Scurrula ferruginea</i> (Jack) Danser)

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