Phytochemical and anti-inflammatory properties of Senegalese propolis and isolated compounds

Inui, Saori; Hosoya, Tsuyoshi; Yoshizumi, Kazuma; Sato, Hajime; Kumazawa, Shigenori

doi:10.1016/j.fitote.2021.104861

Cited by 15 publications

(10 citation statements)

References 37 publications

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“…Propolis extract from China also exerted antiinflammatory properties via attenuating the production of NO, IL-1β, and IL-6 mediated by the phosphorylation of IκBα, AP-1 and NF-κB pathways [8,215]. Senegalese propolis blocked the inflammatory gene iNOS [216]. Propolis extract and the isolated bioactives 2-acetyl-1-coumaroyl-3-cinnamoylglycerol, ( +)-2-acetyl-1-feruloyl-3-cinnamoylglycerol, ( −)-2-acetyl-1-feruloyl-3-cinnamoylglycerol, 2-acetyl-1,3-dicinnamoylglycerol and ( −)-2-acetyl-1-(E)-feruloyl-3-(3″,16″)-dihydroxy-palmitoylglycerol down-regulated the IL-1β, IL-6, cyclooxygenase (COX)-2 mRNA expression in mouse macrophage cells [211,215].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Propolis: An update on its chemistry and pharmacological applications

et al. 2022

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Propolis, a resinous substance produced by honeybees from various plant sources, has been used for thousands of years in traditional medicine for several purposes all over the world. The precise composition of propolis varies according to plant source, seasons harvesting, geography, type of bee flora, climate changes, and honeybee species at the site of collection. This apiary product has broad clinical applications such as antioxidant, anti-inflammatory, antimicrobial, anticancer, analgesic, antidepressant, and anxiolytic as well asimmunomodulatory effects. It is also well known from traditional uses in treating purulent disorders, improving the wound healing, and alleviating many of the related discomforts. Even if its use was already widespread since ancient times, after the First and Second World War, it has grown even more as well as the studies to identify its chemical and pharmacological features, allowing to discriminate the qualities of propolis in terms of the chemical profile and relative biological activity based on the geographic place of origin. Recently, several in vitro and in vivo studies have been carried out and new insights into the pharmaceutical prospects of this bee product in the management of different disorders, have been highlighted. Specifically, the available literature confirms the efficacy of propolis and its bioactive compounds in the reduction of cancer progression, inhibition of bacterial and viral infections as well as mitigation of parasitic-related symptoms, paving the way to the use of propolis as an alternative approach to improve the human health. However, a more conscious use of propolis in terms of standardized extracts as well as new clinical studies are needed to substantiate these health claims.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Propolis: An update on its chemistry and pharmacological applications

et al. 2022

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“…Extensive research was conducted over the years on different molecules identified in the composition of propolis and until 2018 more than 850 compounds were reported, 305 of them isolated for the first time between 2013 and 2018. As propolis samples from unexplored areas (mainly in Africa or Asia) are being analyzed, the number of constituents is constantly increasing, new compounds being reported in studies published between 2018 and 2021, such as new flavanones and phenantrendiol derivatives in African samples, and new prenylflavonoids in Asian samples [19][20][21].…”

Section: Types Of Propolis and Chemical Compositionmentioning

confidence: 99%

Potential Role of Propolis in the Prevention and Treatment of Metabolic Diseases

Balica

Voștinaru

Ştefănescu

et al. 2021

Plants

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Propolis is a resinous mixture with a complex chemical composition, produced by honeybees and stingless bees from a variety of vegetal sources. In the last decades, propolis was extensively researched, multiple studies confirming its anti-inflammatory, antioxidant, antimicrobial, and wound-healing properties. More recently, due to an exponential increase in the number of patients with metabolic diseases, there is also a growing interest in the study of antidiabetic, antihyperlipidemic, and anti-obesity effects of propolis. The aim of this review was to evaluate the potential role of propolis in the prevention and treatment of metabolic diseases like diabetes mellitus, dyslipidemia, and obesity. The preclinical in vivo and in vitro pharmacological models investigating antidiabetic, antihyperlipidemic, and anti-obesity effects of propolis were reviewed with a focus on the putative mechanisms of actions of several chemical constituents. Additionally, the available clinical studies and an evaluation of the safety profile of propolis were also presented.

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“…Bacteria, fungi, and viruses are all affected by these components in different ways. Propolis and its constituents also have anti-inflammatory (Inui et al, 2021) and immunomodulatory properties (Yosri et al, 2021). Propolis has also been demonstrated to reduce blood pressure and cholesterol (Sforcin et al, 2017).…”

Section: Figurementioning

confidence: 99%

Potential Role of Propolis Nanoparticles in Medicine and Health: An Updated Review

Saad¹,

Abdel-Fattah²,

Khamis³

et al. 2021

AAVS

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N anotechnology is the science of very tiny objects with adjacent chemical and physical structures, as well as increased reactivity and solubility. When the active constituent is nanosized, the substance's stability is boosted due to its protection from oxidizing agents, other chemicals, and enzymes (Kirtane et al., 2021). It is predicted for nanotechnology to do significant advances in medicine, as gene therapy, imaging, and novel drug discovery and drug delivery in the treatment of several diseases as diabetes, cancer, and others, in addition to advances in electronics, material science, space research, and robotics (DiSanto et al., 2015;Mohamed et al., 2021). Nanotechnology has a broad and possible impact on veterinary medicine and improves the safety of domestic animals, production, and income to the farmers by using nanomaterials. Approaches in nanoscience have the potential to solve substantial challenges in the field of animal health. It has the potential to resolve dozens of new mysteries relating to veterinary fields (Şenel, 2020).Propolis is a plant resin obtained by bees via variety of plant parts to protect the hive from insects and microbes while also maintaining the hive's appropriate temperature and humidity, it is dark yellow to brown glue and balsam (Drescher et al., 2019). Propolis contains at least 300 components, with resins (50 %), waxes (30 %), essential oils (10 %), pollen (5 %), and other organic compounds (5 %) accounting for the majority. Phenolic parts and esters, as well as various kinds of flavonoids, terpenes, steroids, aromatic beta-aldehydes, alcohols, sesquiterpenes, and stilbenes, can all be found among the organic components. The interaction of these chemicals produces a synergic effect that is crucial to propolis' biological activity. Rutin, caffeic acid phenethyl ester (CAPE), quercetin, p-coumaric review Article Abstract | Nanotechnology is defined as the science and technology of small objects with a diameter of less than 100 nanometers. Nanomaterials may undergo novel chemical and physical changes as a result of their size, indicating increased reactivity and solubility. Nanotechnology has a huge potential to make a major change in the agriculture and livestock sector. It can introduce new tools for molecular and cellular biology, biotechnology, veterinary physiology, animal genetics, and reproduction. Nano-propolis is beneficial to veterinary medicine in different aspects by varying the size of propolis using various techniques, nano-propolis can be more effective without compromising its qualities. Propolis has numerous benefits, including anti-inflammatory, antioxidant, anticancer, and antifungal properties. Low bioavailability, solubility, absorption, and untargeted control, the advantages of free form propolis are limited due to previous reasons. Nano-propolis is made using a variety of nanoencapsulation processes. Because of their smaller size, nano-propolis is more utilized by the body than the free one. This study focuses on some current research on the application ...

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Phytochemical and anti-inflammatory properties of Senegalese propolis and isolated compounds

Cited by 15 publications

References 37 publications

Propolis: An update on its chemistry and pharmacological applications

Propolis: An update on its chemistry and pharmacological applications

Potential Role of Propolis in the Prevention and Treatment of Metabolic Diseases

Potential Role of Propolis Nanoparticles in Medicine and Health: An Updated Review

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