Phytochemical and antibacterial investigations of moringa (Moringa oleifera) leaf extract on selected bacterial pathogens

Abubakar, Ibrahim Ahmad; Abubakar, Usman

doi:10.5897/jma2016.0361

Cited by 18 publications

(12 citation statements)

References 11 publications

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“…Diarrhea, vomiting, and abdominal pain are the most common symptoms of gastroenteritis. Patients may also experience fever, fatigue, and lack of energy, depending on the underlying cause [1], [2], [3].…”

Section: Introductionmentioning

confidence: 99%

A review of Leaves and Seeds Moringa oleifera Extract: The potential Moringa oleifera as Antibacterial, Anti-Inflammatory, Antidiarrhoeal, And Antiulcer Approaches To Bacterial Gastroenteritis

Adji

Atika

Kusbijantoro

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Bacterial gastroenteritis is a disease in the tropics in the form of inflammation of the stomach and intestines due to several bacteria, such as Salmonella, Campylobacter, Shigella, Escherichia coli, Vibrio, Yersinia, and Listeria with symptoms of diarrhea without or with vomiting and frequent fever. Gastroenteritis is a global disease with the highest prevalence in the agricultural community, especially farmers and fishermen. AIM: This research is to determine the potential of leaf and seed extract Moringa oleifera as an alternative therapy for bacterial gastroenteritis. METHODS: A literature review approach derived from the analysis and synthesis of various related references is used. The author selects journals full text and books published in the last ten years maximum through several databases, namely PubMed, Google Scholar, ScienceDirect, and Cochrane with the keywords: diarrhea, gastroenteritis, antibacterial, antiulcer, anti-inflammation, and M. oleifera. RESULTS: Seed and leaf extract M. oleifera played a role in preventing some of the effects of the pathogenesis of diarrhea due to bacterial infection. Methanol, N-hexane, ethyl acetate, flavonoids, phenols, saponins, alkaloids, tannins, and steroids from seed and leaf extract M. oleifera have antibacterial effects. The content of quercetin has an anti-inflammatory effect. The content of tannins, flavonoids, and alkaloids has antidiarrheal activity. The content of ethanol and tannins has an antiulcer effect. This potential can help cure patients with bacterial gastroenteritis. CONCLUSION: Leaf and seed extract of M. oleifera has good antibacterial, anti-inflammatory, antiulcer, and antidiarrheal potential for the treatment of bacterial gastroenteritis.

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Section: Introductionmentioning

confidence: 99%

A review of Leaves and Seeds Moringa oleifera Extract: The potential Moringa oleifera as Antibacterial, Anti-Inflammatory, Antidiarrhoeal, And Antiulcer Approaches To Bacterial Gastroenteritis

Adji

Atika

Kusbijantoro

et al. 2022

Open Access Maced J Med Sci

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“…The presence of phytochemicals in different plant parts of S. didymobotrya have been observed in previous studies (Nyaberi et al, 2013;Ngule et al ., 2013;Nyamwamu et al 2015). Presence of phytochemicals has also been reported in different plant parts of Bombax buonopozense and Monodora myristica (Firempong et al ., 2016) and Moringa oleifera (Abubakar and Usman, 2016). The phytochemicals in the present study differed in their diversity with geographical areas or ecozones and the plant parts (Table 1).…”

Section: Introductionmentioning

confidence: 54%

“…The crude extracts showed activity that surpassed those of the standard antibiotics suggesting that they could be used in treating diseases caused by S. aureus. In their investigations on antibacterial investigations of moringa (Moringa oleifera) leaf extract on S. aureus, Abubakar and Usman (2016) reported that methanol extract had more antibacterial activity than the water extract, more so the extracts were discovered to be more active at higher concentration. They concluded that methanol extract of M. oleifera leaves have a potential antibacterial activity and to cure infections caused by bacteria such as E. coli, S. aureus and S. pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and antibacterial investigations of crude methanol extracts of <i>Senna didymobotrya</i> (Fresen.) H. S. Irwin & Barneby

Jeruto¹,

Arama²,

Anyango³

et al. 2017

J. App. Bioscience.

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Objective: Senna didymobotrya (African senna, African wild sensitive plant, peanut butter cassia, peanut butter tree, popcorn cassia, popcorn senna or wild senna) is native to East Africa and is widely used as a medicinal plant among many communities in Kenya. The objective of this research was to evaluate the presence of phytochemicals present in the different plant parts and their antibacterial activity. Methodology and results: Leaves, flowers, stem bark, immature pods and root barks were collected from Siaya, Nandi and Nakuru Counties. These were dried and ground. Methanolic crude extracts were in cooperated in nutrient media at 2.5 %, 5 %, 7.5 % and 10 %. Test organisms Staphylococcus aureus and Escherichia coli were inoculated on impregnated media, incubated and observed for colony development. Observation on growth of cultures was made at an interval of 2 days for 8 days. The area under disease progress stairs (AUDPS) was calculated using the derived colony surface areas. Results indicated that all plant parts contained terpenoids, phenols and steroids. The presence of alkaloids and flavonoids varied with the location the plant was collected and the plant part. Growth of S. aureus cultures grown on media impregnated with 2.5% root bark extract and that with 7.5% stem bark extract were completely inhibited (no growth). Media with 10% flower, pods and leaves extract had average reduction of colony sizes from AUDPS 10102 (control) to AUDPS 2475. Growth of E. coli was completely inhibited on media impregnated with 5% root bark extract and 7.5% stem bark extracts. At 10% concentration, the flowers, pods and leaves extract did not result in complete inhibition of colony growth. Conclusions and applications: The present research suggests that S. didymobotrya extracts possessed antibacterial activity against bacterial pathogens thus supporting their folkloric usage, promising a future scope for its use against microbial populations. Methanolic extracts possessing high antibacterial effects should be further investigated for their therapeutic utility. This would be related to the presence of bioactive metabolites, which are soluble in methanol. There is need to explore further the quantities of phytochemicals in the root and 11358stem barks that make them more potent than the other plant parts. The structures of the bioactive metabolites should be examined in future.

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“…This finding supports the previous study of M. oleifera using ethanolic extract can kill the growth of the bacterial isolates completely. 21…”

Section: Antibacterial Results (Microdilution Method)mentioning

confidence: 99%

“…M.oleifera possess some phytoconstituents saponins, tannins, phenols alkaloids. 9, 21 The constituents…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activities of moringa olifiera freeze dried extract on staphylococcus aureus

Angestia

Ningrum

Lee

et al. 2020

J Dentomaxillofac Sci

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Objective: The aim of this study is to determine the antibacterial activities of M. oleifera freeze dried extract on Staphylococcus aureus. Material and Methods: The antibacterial activities using two methods, microdilution method and agar diffusion method. The minimum inhibitory concentration is determined. The measurement of absorbance in microdilution method using a spectrophotometer at length wave 590 nm. The inhibition zone is measured using scalimeter. Results:The results showed both microdilution method and agar diffusion method present the inhibition activity of M. oleifera freeze dried extract on staphylococcus aureus. Conclusion:The finding confirmed M. oleifera freeze dried extract as the promising antibacterial natural agent, particularly on inhibiting S. aureus strain.

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Phytochemical and antibacterial investigations of moringa (Moringa oleifera) leaf extract on selected bacterial pathogens

Cited by 18 publications

References 11 publications

A review of Leaves and Seeds Moringa oleifera Extract: The potential Moringa oleifera as Antibacterial, Anti-Inflammatory, Antidiarrhoeal, And Antiulcer Approaches To Bacterial Gastroenteritis

A review of Leaves and Seeds Moringa oleifera Extract: The potential Moringa oleifera as Antibacterial, Anti-Inflammatory, Antidiarrhoeal, And Antiulcer Approaches To Bacterial Gastroenteritis

Phytochemical screening and antibacterial investigations of crude methanol extracts of <i>Senna didymobotrya</i> (Fresen.) H. S. Irwin & Barneby

Antibacterial activities of moringa olifiera freeze dried extract on staphylococcus aureus

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