Phytochemical and antifungal activity of anthraquinones and root and leaf extracts of Coccoloba mollis on phytopathogens

Barros, Iuri Bezerra de; Daniel, Juliana Feijó de Souza; Pinto, Jurandir Pereira; Rezende, Maria Inês; Filho, Raimundo Braz; Ferreira, Dalva Trevisan

doi:10.1590/s1516-89132011000300015

Cited by 33 publications

(23 citation statements)

References 22 publications

(16 reference statements)

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“…Emodin has been previously reported to have antifungal and anti-bacterial properties. Emodin was also found to be efficiently active against fungal spore germination [26]. Several other phytochemicals reported in this study like Wighteone (flavonoid) [27], SchizolaenoneB (flavonoid) [28], Narlumidine, papraline and Narlumicine (alkaloid) [29], Mundulinol (flavonoid) [30] and Hydroxymunduserone (isoflavone) [31], etc.…”

Section: Discussionsupporting

confidence: 52%

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

2019

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The HIV-1 protease plays an essential role in the replication cycle of HIV-1; therefore there is a direct need to develop novel inhibitors of the HIV-1 protease, which can cease the viral replication. The present study targets the discovery of potential inhibitors of HIV-1 protease from a set of phytochemicals. From 2505 phytochemicals, 108 compounds were docked, after screening, with the HIV-1 protease to analyze their inhibitory potential against the protease. DFT analysis was also conducted to study the reactivity of strongly docked compounds. Out of 108 phytochemicals, 38 compounds showed binding affinity greater than the desired threshold. Reactivity of these 38 inhibitors was also high as compared to other compounds, based on the DFT results. These results suggest that the selected 38 phytochemicals are drug candidates and they have the potential to be effectively used against HIV in the future.

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Section: Discussionsupporting

confidence: 52%

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

2019

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“…Natural products, in particular from plants, can be the potential candidates which can be used against phytopathogenic fungi. The use of these agents is risk to synthetic chemicals (Gomathi and Kannabiran, 2000;Abou-Zeid et al, 2008;Yazdani al., 2011;de Barros et al, 2011;Bajpai and Kang, 2012;Dileep et al, 2013). several hazardous effects.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Radical Scavenging Efficacy of Leaf and Flower of <i>Aristolochia indica</i> Linn.

Abhishiktha¹,

Saba²,

Shrunga³

et al. 2015

Sci. Technol. Arts Res. J.

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The present study was performed to screen antibacterial, antifungal and radical scavenging efficacy of leaf and flower extract of Antibacterial and antifungal activity was evaluated by agar well diffusion and poisoned food technique respectively. Radical scavenging potential was determined by DPPH free radical scavenging assay. Overall, Leaf extract and flower extract displayed stronger antibacterial and antifungal activity respectively. Leaf extract was found to scavenge DPPH radicals more effectively when compared to flower extract. In suitable form, the plant can be used against microbial infections and oxidative stress.

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“…Root ethanolic extract of A. polyneuron was submitted to acid-base treatment for alkaloid extraction (de Barros et al 2011). The product was submitted to column chromatography on silica gel eluted by solvents in increasing gradient of polarity (hexane, acetone, methyl acetate and methanol) resulting in 469 fractions (250 mL).…”

Section: Aspidospermine and Chemical Agents Induce Cellular Damagementioning

confidence: 99%

Cytotoxicity, genotoxicity and mechanism of action (via gene expression analysis) of the indole alkaloid aspidospermine (antiparasitic) extracted from Aspidosperma polyneuron in HepG2 cells

et al. 2015

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Aspidospermine is an indole alkaloid with biological properties associated with combating parasites included in the genera Plasmodium, Leishmania and Trypanossoma. The present study evaluated the cytotoxicity (resazurin test), genotoxicity (comet assay) and mechanism of action (gene expression analysis via qRT-PCR) of this alkaloid in human HepG2 cells. The results demonstrated that treatment with aspidospermine was both cytotoxic (starting at 75 lM) and genotoxic (starting at 50 lM). There was no significant modulation of the expression of the following genes: GSTP1 and GPX1 (xenobiotic metabolism); CAT (oxidative stress); TP53 and CCNA2 (cell cycle); HSPA5, ERN1, EIF2AK3 and TRAF2 (endoplasmic reticulum stress); CASP8, CASP9, CASP3, CASP7, BCL-2, BCL-XL BAX and BAX (apoptosis); and PCBP4, ERCC4, OGG1, RAD21 and MLH1 (DNA repair). At a concentration of 50 lM (non-cytotoxic, but genotoxic), there was a significant increase in the expression of CYP1A1 (xenobiotic metabolism) and APC (cell cycle), and at a concentration of 100 lM, a significant increase in the expression of CYP1A1 (xenobiotic metabolism), GADD153 (endoplasmic reticulum stress) and SOD (oxidative stress) was detected, with repression of the expression of GR (xenobiotic metabolism and oxidative stress). The results of treatment with aspidospermine at a 100 lM concentration (the dose indicated in the literature to achieve 89 % reduction of the growth of L. amazonensis) suggest that increased oxidative stress and an unfolded protein response (UPR) occurred in HepG2 cells. For the therapeutic use of aspidospermine (antiparasitic), chemical alteration of the molecule to achieve a lower cytotoxicity/genotoxicity in host cells is recommended.

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Phytochemical and antifungal activity of anthraquinones and root and leaf extracts of Coccoloba mollis on phytopathogens

Abstract: ABSTRACT

Cited by 33 publications

References 22 publications

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

Antimicrobial and Radical Scavenging Efficacy of Leaf and Flower of <i>Aristolochia indica</i> Linn.

Cytotoxicity, genotoxicity and mechanism of action (via gene expression analysis) of the indole alkaloid aspidospermine (antiparasitic) extracted from Aspidosperma polyneuron in HepG2 cells

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