Phytochemical and Antimicrobial Activity of <i>Digera Muricata</i> (L.) Mart.

Mathad, Pratima; Mety, Sundar S.

doi:10.1155/2010/509254

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…The presence of tannin in the medicinal plant suggests the ability of these plants to play major roles as antifungal, antidiarrheal, antioxidant and anti-hemorrhoidal agent [46]. The result of this work is in agreement with the findings of [47] Using dry mycelial weight assay, the methanolic extracts of the stem bark of A. boonie at different concentrations exhibited strong antifungal activity on the test fungi ( Table 7). At 200 mg/ml, the methanolic extract of A. boonie had a strong antifungal activity on dry mycelial weight of A. flavus, A. corymbifera and A. niger with dry mycelial weight of 45.00, 38.00 and 68.00 mg respectively, while their control was 125.00, 145.00 and 215.00 mg respectively.…”

Section: Resultssupporting

confidence: 87%

Antifungal Effects of Methanolic Extract of Stem Bark of Bridelia ferruginea Benth. Leaves of Aloe vera L. and Stem Bark of Alstonia boonei De Wild

Fagbohun

Bamikole

2019

MRJI

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The antifungal activities, proximate and phytochemical constituents of Aloe vera leaves extract, stem barks of both Alstonia boonei and Bridelia ferruginea were investigated. The methanolic crude extracts of these plants parts were tested for antifungal activity at different concentrations of 50.0, 100.0, 150.0, 200.0 mg/mL, respectively against against Aspergillus flavus, Absidia corymbifera and Aspergillus niger. Radial mycelial growth and dry mycelial weight methods were used to test for the extract activities against these fungi. The results of antifungal activity showed that all the plant extracts exhibited strong antifungal activities at higher concentration of 200.0 mg/mL. The phytochemical results showed that all the three medicinal plants contained steroid, flavonoid, phytate, phenol and oxalate which were known to exhibit antimicrobial properties as well as physiological activities. The proximate analyses showed that all the three medicinal plants contained appropriate amount of ashes, crude fibre and high carbohydrate content which provide energy when consumed. The results of this study showed that these plants possess some antifungal properties therefore the medicinal plants could serve as a potential source of active ingredients for the production of antifungal drugs.

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Section: Resultssupporting

confidence: 87%

Antifungal Effects of Methanolic Extract of Stem Bark of Bridelia ferruginea Benth. Leaves of Aloe vera L. and Stem Bark of Alstonia boonei De Wild

Fagbohun

Bamikole

2019

MRJI

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“…18 Mathad and Mety revealed the antibacterial potential of chloroform, petroleum ether, ethanol and aqueous extracts of the D. muricata against K. pneumonia, S. aureus, E. coli, V. cholerae and S. typhi. 7 Jain et al also observes similar results and found 0.781 mg/mL MIC in D. muricata extracts against P. aeruginosa represents the presence of antimicrobial activity in the D. muricata plants. 19 In another study the leaf extract showed maximum antimicrobial potential against F. oxysporum and E. coli.…”

Section: Discussionmentioning

confidence: 55%

“…6 The petroleum ether extract of D. muricata is effective against the Vibrio cholerae infection. 7,8 The plant of D. muricata supports the defense against toxicity induced by CCl 4 , emphasizing therapeutic importance. 9 The D. muricata root extracts have phenols and sugar, while the leaves have primary metabolites, including proteins, lipids and carbohydrates and showed antimicrobial potential against Fusarium oxysporum and Escherichia coli.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Bioactive Potential of the Digera muricata Mart

Tomer¹,

Ali²,

Moin³

2022

IJPQA

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Digera muricata (L.) mart (Amaranthaceae) is a promising medicinal plant used as a prophylactic, antioxidant, anthelmintic, antimicrobial, allelopathic, and antidiabetic. The present study assesses the quantification of primary and secondary metabolites along with the antimicrobial potential of D. muricata. Qualitative and quantitative phytochemical analysis was undertaken to evaluate secondary metabolites extracted from leaf extracts of D. muricata by using standard methods. The antibacterial and antifungal potential was studied by using the disc diffusion method. A (gas chromatography-mass spectrometry) (GC–MS) study was carried out to recognize the bioactive molecules in the active fraction. D. muricata contained carbohydrates, proteins, steroids, amino acids, cardiac glycosides, coumarin, polyphenol, alkaloids, saponin, tannin, and flavonoids. Results also indicate that ethyl acetate extracts of D. muricata showed significant antimicrobial potential against Streptococcus agalactiae (ATCC13813), Klebsiella pneumoniae (MTCC432), Escherichia coli (MTCC730), Streptococcus pyogenes (MTCC1924), Macrophomina phaseolina, and Candida albicans (MTCC7315). These findings showed that the ethyl acetate extract of D. muricata confined bioactive molecules of therapeutic rank with significant antibacterial and antifungal activity.

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“…Using the MTT assay, several herbals and phytochemicals have been shown to have cytoprotective properties [44]. Flavonoids, alkaloids, terpenoids, saponins, coumarins, tannins, cardiac glycosides, and anthraquinones were found in different fractions of the D. muricata [45]. In Digera muricata methanol extract, the percentages of flavonoids (5.26±0.09), saponins (3.13±0.11), alkaloids (0.64±0.01) and tannins (0.35±0.14) had been determined in a study [46].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Proapoptotic Effect of Digera muricata Leaf Extract against the Skin Cancer Cell Line (B16-F10)

Dhivyadharshini

Elumalai

Subramanian

et al. 2021

JPRI

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Introduction: Skin cancers, such as melanoma, basal cell carcinoma, and squamous cell carcinoma, frequently begin as changes in the skin. Cancer research continues to focus on finding tumor-selective and new anticancer drugs with fewer adverse effects. Digera muricata is a medicinal herb in the Amaranthaceae family that has antibacterial, antifungal, free radical scavenging function, anti tumor, and other valuable medicinal properties. Aim: To investigate the pro-apoptotic effect of Digera muricata leaf extract against the skin cancer cell line. Materials and Methods: MTT assay was used to determine the viability of B16-F10 cells treated with different concentrations (20-200μg) of Digera muricata leaf extract. Phase contrast microscopy was used to examine the morphological changes. In addition, the mode of cell death was assessed using AO/EtBr dual staining and observed under a fluorescence microscope. Statistical analysis was performed, keeping the level of significance at p<0.05. Results: The MTT assay revealed that the ethanolic extract of Digera muricata leaf had significant cytotoxic and apoptotic potency against the B16-F10 skin cancer cell line, which was validated by significant morphological alterations under phase contrast microscope after 24 hours of treatment. AO/EtBr dual staining results clearly showed the Digera muricata leaf extract treatment induced the early apoptotic cells with bright orange areas of condensed or fragmented chromatin in the nucleus. Late apoptotic cells showing uniform bright red nucleus. Conclusion: Within the limits of the analysis, it can be inferred that the leaf extract of Digera muricata was cytotoxic and triggered cancer cell apoptosis at a concentration of 50 μg/ml within 24 hours. More research is needed to understand the cytotoxicity mechanisms of this plant extract.

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Phytochemical and Antimicrobial Activity of Digera Muricata (L.) Mart.

Cited by 12 publications

References 6 publications

Antifungal Effects of Methanolic Extract of Stem Bark of Bridelia ferruginea Benth. Leaves of Aloe vera L. and Stem Bark of Alstonia boonei De Wild

Antifungal Effects of Methanolic Extract of Stem Bark of Bridelia ferruginea Benth. Leaves of Aloe vera L. and Stem Bark of Alstonia boonei De Wild

Evaluation of Bioactive Potential of the Digera muricata Mart

Investigation of Proapoptotic Effect of Digera muricata Leaf Extract against the Skin Cancer Cell Line (B16-F10)

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