Phytochemical and antimicrobial studies on Butyrospermum paradoxum

Ogunwande, Isiaka A.; Bello, Muibat Olabisi; Olawore, Olayide N.; Muili, Kamaldin A

doi:10.1016/s0367-326x(00)00238-0

Cited by 12 publications

(7 citation statements)

References 5 publications

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“…Given the results presented here, shea meal may have potential for promising applications as a nutraceutical anthelmintic feed for controlling A. suum and possibly other pathogens Ogunwande et al, 2001). Shea meal could also provide a valuable and cost-effective alternative to imported, synthetic anthelmintic drugs in areas where shea nuts are harvested and where livestock production may be threatened by resistance to anthelmintic drugs (Sutherland and Leathwick, 2011).…”

Section: Discussionmentioning

confidence: 86%

Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum

et al. 2016

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Proanthocyanidins (PA) from shea (Vitellaria paradoxa) meal were investigated by thiolytic degradation with benzyl mercaptan and the reaction products were analysed by high performance liquid chromatography-mass spectrometry. These PA were galloylated (≈40%), contained only B-type linkages and had a high proportion of prodelphinidins (>70%). The mean degree of polymerisation was 8 (i.e. average molecular size was 2384Da) and epigallocatechin gallate (EGCg) was the major flavan-3-ol subunit in PA. Shea meal also proved to be a potentially valuable source for extracting free flavan-3-ol-O-gallates, especially EGCg (575mg/kg meal), which is known for its health and anti-parasitic benefits. Proanthocyanidins were isolated and tested for bioactivity against Ascaris suum, which is an important parasite of pigs. Migration and motility tests revealed that these PA have potent activity against this parasitic nematode.

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Section: Discussionmentioning

confidence: 86%

Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum

et al. 2016

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“…paradoxa (Sapotaceae) Vitellaria paradoxa is an immensely popular tree because the fat extract from the kernels called shea butter is widely used in cosmetic industries (Hall et al 1996). The antimicrobial activity of its stem bark and leaves was already studied on strains of Staphylococcus aureus but with an agar well diffusion method at high concentration (50 g/L) (Ayankunle et al 2012;Ogunwande et al 2001).…”

Section: Tapinanthus Bangwensis (Engl and Krause) Danser (Loranthaceae)mentioning

confidence: 99%

Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa

2015

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In a world of increasing resistance to current antibiotics, search of novel therapeutic options is urgently needed. The aim of this work was to screen plant crude extracts for direct or indirect (inhibition of resistance) antimicrobial activity. Four crude extracts from 12 plants traditionally used in Africa for the treatment of infections were obtained by successive extraction with hexane, dichloromethane, ethyl acetate, and methanol. All extracts were tested against Staphylococcus aureus MRSA ATCC33591 [resistant to b-lactams by production of b-lactamases and of a modified PBP target (PBP2a)]. Direct antimicrobial activity was tested by determination of Minimal Inhibitory Concentrations (MIC), and indirect activity, by determining interactions between antibiotics and extracts using checkerboard titration and calculation of Fractional Inhibitory Concentration Index (FICI; synergy: FICI B 0.5; additivity: FICI B 1). Combined antibiotics were ampicillin (sensitive to resistance mediated by b-lactamases and PBP2a) and oxacillin (sensitive to resistance mediated by PBP2a only). The dichloromethane extract of Vitellaria paradoxa leaves, the methanol extracts of Vitellaria paradoxa, Cola gigantea leaves and twigs, and of Tapinanthus bangwensis aerial parts showed direct antimicrobial activity (MIC 250-500 mg/L). The methanol extracts of Vitellaria paradoxa and Cola gigantea leaves and twigs showed additive or synergistic effects with oxacillin and ampicillin on MRSA ATCC33591 (FICI 0.28-1), suggesting a possible inhibition of PBP2a. The methanol extract of Tapinanthus bangwensis aerial parts and Anchomanes difformis roots improved the activity of ampicillin only (FICI 0.38-1), suggesting b-lactamase inhibition. Polyphenols and particularly tannins were shown to be responsible for these last effects, at least partially for Vitellaria paradoxa. These data need further research aiming at identifying the active compounds in these extracts.

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“…Decoctions of leaves and barks are traditionally used in Burkina Faso to treat malaria, fever and many other disorders such as pain, inflammation, and gastrointestinal disorders. The antibacterial and antifungal properties of Vitellaria paradoxa have been demonstrated by Ogunwande et al (2001) for different parts of this plant. In our study, the best results were obtained with dichloromethane extracts.…”

Section: Vitellaria Paradoxa Gaertn (Syn Butyrospermum Paradoxum Hementioning

confidence: 99%

Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties

Jansen

Angenot

Tits

et al. 2010

Journal of Ethnopharmacology

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Phytochemical and antimicrobial studies on Butyrospermum paradoxum

Cited by 12 publications

References 5 publications

Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum

Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum

Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa

Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties

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