Phytochemical and Antioxidant Investigation of Barringtonia acutangula (L.)

Asaduzzaman, Md.; Rana, Md. Sohel; Hasan, Shemonty; Islam, Rakibul; Das, Nittananda

doi:10.9734/ejmp/2015/5400

Cited by 20 publications

(19 citation statements)

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“…Thus, exposure or administering this type of compound may unlikely to have negative effects on human (Moshi et al, 2010). This agrees with the report of (Asaduzzaman et al, 2015) that brine shrimp lethality test gives a significant correlation between brine shrimp assay and in-vitro growth inhibition of human solid tumour cell lines as well the detect of antitumor compounds in terrestrial plant extracts. The result obtained on the cytotoxicity assays of the Methyl biphenyl-4-Carboxylate (1) and Methyl salicylate (2), it could as well be used in the synthesis of more drugs to avert human pathogens, antitumor as well as anticancer figures are in mm and include the diameter of the paper disc (5mm).…”

supporting

confidence: 91%

“…There was an observed concentration dependent increment in mortality rate of the Brine shrimp of all the pure compounds the lethality of a test of pure compound in a simple zoological organism such as the shrimp (Artemia salina) has been utilized in the Brine Shrimp Cytotoxicity Test (BSCT). It is a very useful tool to screen a wide range of chemical compounds for their various bioactivities (Asaduzzaman et al, 2015). The Brine Shrimp Lethality Bioassay also indicates antifungal effects, pesticidal effects, teratogenic effects, toxicity to environment (Sarah et al, 2017).…”

mentioning

confidence: 99%

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Isolation and Characterization of Chemical Constituents, Cytotoxicity, Antibacterial and Antioxidant Activity of the Compounds from Leptadenia hastata Roots Extract By

Umaru¹,

Umaru²

2019

American Journal of Biochemistry and Biotechnology

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The aim of this work was to extract, isolate and characterise the chemical constituent from Leptadenia hastata roots. Fresh roots were washed and dried and was subjected to sequential maceration in polar and non-polar solvents. And introduced into rotary evaporator to concentrate the extract. Isolated compound was subjected to Thin Layer Chromatography and spectral analysis such as column and UV-Visible spectroscopy were used in the detection of the spots, Gas Chromatography-Mass Spectrophotometric (GC-MS). Characterization was done using Nuclear Magnetic Resonance and Furrier Transform-Infra Ray (FT-IR) as shown the flow chart. Disc diffusion method was applied for the antibacterial test. Brine shrimp for cytotoxicity, DPPH for Antioxidant. The isolated compound were Methyl biphenyl-4-Carboxylate (1) and Methyl salicylate (2). Higher cytotoxicity was observed in the isolated pure compound with LC50 of 8.770 µg/mL and 23.982 µg/mL. The Antioxidant IC50 activity was observed to be 77.79 µg/mL and 61.96 µg/mL and the compounds was observed to have significant activity on Escherichia coli, Klebsiella pneumonia and Salmonella typhi. From this studies it was concluded that the isolated compounds from the root extract of Leptadenia hastata was confirmed as Methyl biphenyl-4-Carboxylate (1) and Methyl salicylate (2) and a very strong Antioxidant, cytotoxicity, was established. Antibacterial potential was observed against Escherichia coli, Klebsiella pneumonia and Salmonella typhi. Thus could be used as an agent for anticancer, antibacterial and as a good source of antioxidant. This compounds though common was isolated and characterized for the first time from the roots extracts Leptadenia hastata.

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supporting

confidence: 91%

mentioning

confidence: 99%

Isolation and Characterization of Chemical Constituents, Cytotoxicity, Antibacterial and Antioxidant Activity of the Compounds from Leptadenia hastata Roots Extract By

Umaru¹,

Umaru²

2019

American Journal of Biochemistry and Biotechnology

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“…The vials were placed under light for a period of 24 h. 24 h later, the vials were inspected and the number of survived nauplii in each vial was counted and recorded. In this case, vincristine sulphate was used as a reference standard [21].…”

Section: Brine Shrimp Lethality Bioassaymentioning

confidence: 99%

Anti-diarrheal activity and brine shrimp lethality bioassay of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves

et al. 2019

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Background: Cordyline fruticosa (L.) A. Chev. (Asparagaceae) is a plant which is traditionally used for the treatment of cough, bloody cough, diarrhea, dysentery, high fever, difficulties in urine, bloody urine, small pox, madness, skin eruptions, joint pains, rheumatic bone pains, sore throat, neck pain, bleeding hemorrhoids and inflammation in the digestive tract. Therefore, the present work aims to investigate the antidiarrheal and cytotoxic activities of methanolic extract of Cordyline fruticosa leaves in mice and brine shrimp, respectively. Methods: The effects of the methanol extract of Cordyline fruticosa leaves (MCFL) on castor oil-induced diarrhea, magnesium sulphate induced diarrhea and charcoal meal test in mice were investigated. In addition, brine shrimp lethality bioassay method was used to evaluate cytotoxic activity of MCFL. Results: In castor oil induced diarrheal test, MCFL at the dose of 200, 400 and 800 mg/kg body weight significantly (* P< 0.05, versus control) and dose-dependently reduced the frequency of diarrhea. The frequency of magnesium sulphate-induced diarrhea was significantly reduced by MCFL at the dose of with 800 mg/kg. In the charcoal meal test, the extract at the dose of 400 and 800 mg/kg body weight significantly (* P< 0.05) reduced the distance travelled by charcoal along the intestinal tract when compare with control. However, in brine shrimp lethality test after 24 h, surviving brine shrimp nauplii were counted and LC 50 was assessed. The extract exhibited considerable toxicity towards brine shrimp with LC 50 value of 355.7 μg/mL,with respect to standard vincristine sulfate (having LC 50 of 3.8 μg/mL). Conclusion: The results of present investigation suggest that methanolic extract of Cordyline fruticosa leaves possesses antidiarrheal and cytotoxic activities, confirming the traditional use of the plant in the treatment of diarrhea.

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“…Nilai LC 50 lebih rendah dari 1000 μg/ml dianggap mempunyai kompinen senyawa bioaktif [3]. BSLT juga menunjukkan efek antijamur, efek pestisida, efek teratogenik, toksisitas terhadap lingkungan dan banyak lagi [9].…”

Section: Penapisan Fitokimiaunclassified

UJI TOKSISITAS DAUN BELUNTAS (Pluchea Indica Less), DAUN KEMANGI (Ocimum Basilicum L.), KULIT BIJI JENGKOL (Archidendron Pauciflorum) DAN KULIT RIMPANG KENCUR (Kaempferia Galanga Linn.) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)

Ratu¹,

Wirasti

2018

JFSP

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Metode BSLT merupakan salah satu cara yang cepat dan murah untuk skrining toksisitas dariekstrak tanaman dengan menggunakan hewan laut yaitu larva udang Artemia salina Leach. Metodeini sering dikaitkan dengan metode penapisan senyawa antikanker. Berdasarkan alasan tersebut,maka uji ini sangat tepat digunakan dalam mengawali penelitian bahan alam. Selain BSLT, jugadilakukan penapisan fitokimia. Hasil penelitian dengan metode BSLT dari ekstrak etanol daunbeluntas, kulit biji jengkol, daun kemangi, dan kulit rimpang kencur menunjukkan LC50 masingmasingsebesar 80,33 mg/L, 39,81 mg/L, 46,42 mg/L, dan kurang dari 10 mg/L. Hasil penapisanfitokimia menunjukkan bahwa ekstrak etanol daun beluntas dan kemangi terdapat flavonid, ekstraketanol kulit biji jengkol dan kulit rimpang kencur terdapat alkaloid. Ekstrak etanol kulit rimpangkencur menunjukan aktivitas tertinggi, maka perlu dilakukan isolasi dan identifikasi sehinggadiperoleh senyawa aktif.

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Phytochemical and Antioxidant Investigation of Barringtonia acutangula (L.)

Cited by 20 publications

References 0 publications

Isolation and Characterization of Chemical Constituents, Cytotoxicity, Antibacterial and Antioxidant Activity of the Compounds from Leptadenia hastata Roots Extract By

Isolation and Characterization of Chemical Constituents, Cytotoxicity, Antibacterial and Antioxidant Activity of the Compounds from Leptadenia hastata Roots Extract By

Anti-diarrheal activity and brine shrimp lethality bioassay of methanolic extract of Cordyline fruticosa (L.) A. Chev. leaves

UJI TOKSISITAS DAUN BELUNTAS (Pluchea Indica Less), DAUN KEMANGI (Ocimum Basilicum L.), KULIT BIJI JENGKOL (Archidendron Pauciflorum) DAN KULIT RIMPANG KENCUR (Kaempferia Galanga Linn.) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)

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