Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury

Abstract

IntroductionPhytochemicals present in Moringa oleifera (M. oleifera) leaves have performed several physiological functions in human system such as anticarcinogenic, antidiabetic, antioxidant, immunomodulatory, hepatoprotective and antiatherogenic functions.MethodsPhytochemical and antioxidant potential of M. oleifera leaves extracts were measured. Histopathology, biochemical analysis, and gene expression tests were performed on serum, blood, and liver in animal model.Results and discussionsThe toxic dose of N-acetyl-para-aminophenol (APAP) induced severe structural and functional changes in liver. Pre-treatment with M. oleifera ameliorated organ injury by normalizing the level of liver biomarkers and serum proteins. A low expression level of MAPK-8, TRAF-4, and TRAF-6 genes was observed in the M. oleifera treated group in comparison to positive control (hepatotoxic rats). M. oleifera leaves pretreatment amended APAP induced apoptosis and replenished hepatic cells. M. oleifera leaves extract as low-cost and sustainable treatment could be used in pharmaceutical industry for reducing hepatic degenerative changes in non-communicable diseases.

Phyto‐Fabrication of Moringa Oleifera Peel‐Sourced Silver Nanoparticles: A Promising Approach for Combating Hepatic Cancer by Targeting Proinflammatory Cytokines and Mitigating Cytokine Storms

“…The results indicated by change in antioxidant parameters were more significant in Moe and MOAgNPs than positive control and DEN+silymarin treated group of experimental animals. These findings indicate that MOe and MOAgNPs may have potential antioxidant effects, which could be beneficial in countering cytokine storms and hepatocellular carcinoma, contributing to their potential therapeutic value in such conditions [33] …”

“…These findings indicate that MOe and MOAgNPs may have potential antioxidant effects, which could be beneficial in countering cytokine storms and hepatocellular carcinoma, contributing to their potential therapeutic value in such conditions. [33]…”

The Protective Effect of <i>Moringa oleifera</i> Leaves Extract on Paracetamol Hepatotoxicity in Male Rats

“…Moringa oleifera upholds phytochemical components that facilitate the regulation of naturally occurring antioxidant enzymes, which aid in tackling the production of ROS. Additionally, the phytochemical components help normalize the increased levels of biochemical parameters due to paracetamol hepatoxicity on the functioning enzymes [29].…”

“…There is also the generated aptitude of extended liver functionality by MO through inhibition of the underlying cellular stress signaling cascades coupled with under-regulation of MAPK-8, TRAF-4, and TRAF-6 expression. The underlined MAPK-8, TRAF-4, and TRAF-6 proteins are significant for facilitating inflammatory activity [29].…”

Shelf-Life Feasibility Study of Moringa oleifera Seasoned Beef

“…M. oleifera leaf extracts can reduce the microbial load of treated meat under cold conditions [20] and may also act as a natural antioxidant to inhibit lipid oxidation in some meat products [21]. Apart from this, it also contains phenolic compounds which possess antiinfammatory, antioxidant, neuroprotective, and hepatoprotective activities [22] which can reduce the risk of cardiovascular diseases and diabetes [23].…”