Phytochemical and biological research of Cannabis pharmaceutical resources

Hao, Da‐Cheng; Gu, Xiao-Jie; Xiao, Pei

doi:10.1016/b978-0-08-100085-4.00011-6

Cited by 9 publications

(8 citation statements)

References 93 publications

(69 reference statements)

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“…Cannabis sativa L. is an ancient crop that has recently gained much international attention due to the increasing demand for phytocannabinoids for therapeutic use. Of the more than 100 phytocannabinoids identified in the plant, only a handful have been researched in varying degrees of detail. − Of these, psychoactive Δ 9 -tetrahydrocannabinol (Δ 9 -THC or THC) and nonpsychoactive cannabidiol (CBD) are the most prevalent in the plant and therefore have traditionally attracted the most interest. THC can interact with cannabinoid receptors 1 (CB 1 ) and 2 (CB 2 ) in the human endocannabinoid system and has a number of known pharmacological properties (modulation of pain, spasticity, sedation, appetite, and mood; bronchodilator; neuroprotective antioxidant and anti-inflammatory); however, its psychoactive effects greatly restrict access to this substance.…”

Section: Introductionmentioning

confidence: 99%

Cannabinoid Decarboxylation: A Comparative Kinetic Study

Moreno

Dyer

Tallon

2020

Ind. Eng. Chem. Res.

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Cannabinoids like Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabigerol (CBG) are considered the main active components in Cannabis sativa L. and are obtained through the decarboxylation of their acid analogues (THCA, CBDA, and CBGA), which are the forms naturally present in the plant. The kinetics of this reaction were studied for hemp plant material in an oven at different temperatures (80–160 °C) and reaction times (5–120 min). The effect of oxygen and the amount of plant material on the reaction rate was also studied. The reactions follow first-order kinetics, with THCA showing the fastest decarboxylation rate. In all cases, a significant loss of neutral cannabinoids was observed at elevated temperatures and reaction times, although this can be minimized in the absence of oxygen. Two different kinetic models were used to fit the experimental data and to predict the optimum decarboxylation conditions to maximize THC or CBD concentration.

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Section: Introductionmentioning

confidence: 99%

Cannabinoid Decarboxylation: A Comparative Kinetic Study

Moreno

Dyer

Tallon

2020

Ind. Eng. Chem. Res.

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“…Terpenes have a wide range of applications in food, cosmetics, and the pharmaceutical industry. Terpenoids, such as limonene, myrcene, α-pinene, and linalool, have been designated as generally recognized as safe (GRAS) by the FDA [46]. For instance, limonene has a lemon fragrance and is used as a flavoring agent in foods, beverages, chewing gum, ice cream, candy, baked goods, etc.…”

Section: Pistacia Terebinth L Fruit Oil Quality Parameters and Aroma ...mentioning

confidence: 99%

Effect of Encapsulation Techniques on Aroma Retention of Pistacia terebinthus L. Fruit Oil: Spray Drying, Spray Freeze Drying, and Freeze Drying

Yaman,

Koçak Yanık,

Elik Demir

et al. 2023

Foods

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The primary aim of this investigation was to assess the impact of varying the ratio of gum arabic to maltodextrin and employing diverse encapsulation techniques on the properties of the powdered substance and the capacity to retain the aromatic attributes of terebinth fruit oil. Distinct ratios of gum arabic to maltodextrin (75:25, 50:50, and 25:75) were employed to fabricate oil-in-water emulsions. The utmost stability of the emulsion was realized at a gum arabic to maltodextrin ratio of 75:25, characterized by a minimal creaming index and an even and small-scale dispersion. The encapsulation techniques employed included spray drying (SD), spray freeze-drying (SFD), and freeze-drying (FD). These methodologies were compared based on encapsulation efficiency, desiccation yield, powder attributes, and the capacity to retain aroma. The encapsulation efficiencies were notably higher (>90%) in SD, particularly with the application of an ultrasonic nozzle and a two-fluidized nozzle (2FN), in contrast to those obtained through SFD and FD. Notably, SD employing an ultrasonic nozzle exhibited superior preservation of volatiles (73.19%) compared to FD (24.45%), SD-2FN (62.34%), and SFD (14.23%). Among the various components, α-pinene and linalool stood out with near-perfect retention rates, close to 100%.

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“…Cannabis directly affects this process via two different avenues; on the one hand, it promotes forgetting and the destruction of existing neural architecture (i.e. this aids in destroying bad memories), and on the other hand, it enhances neuroplasticity and the formation of new neuronal connections (Mechoulam and Parker, 2013;Hao et al, 2015). Not only can PTSD cause the slide into depression, but, like depression, it causes excessive stress on the body and the brain (Brady et al, 2000;De Palma et al, 2015;Stoppelbein et al, 2011).…”

Section: The Beginning Of the End Of The Beginningmentioning

confidence: 99%

Tales of the Frenchfry: on Cannabis and uphill battles

Fry¹

2018

DAT

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Purpose The purpose of this paper is to disclose the author’s personal experiences regarding the war on drugs, specifically detailing cannabis encounters. Design/methodology/approach This work is autobiographical, with notes of science-based fact. Findings Cannabis could be the gateway to the end of the war on drugs. Social implications The hope for this publication is to explain some of the author’s hope is that by sharing the author’s personal story, people will rally behind the cause of cannabis legalisation and legitimisation; resources are included at the bottom of the document. Originality/value It is the author’s story, so hopefully it is original.

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Phytochemical and biological research of Cannabis pharmaceutical resources

Cited by 9 publications

References 93 publications

Cannabinoid Decarboxylation: A Comparative Kinetic Study

Cannabinoid Decarboxylation: A Comparative Kinetic Study

Effect of Encapsulation Techniques on Aroma Retention of Pistacia terebinthus L. Fruit Oil: Spray Drying, Spray Freeze Drying, and Freeze Drying

Tales of the Frenchfry: on Cannabis and uphill battles

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