Phytochemical and biological research of Papaver pharmaceutical resources

Hao, Da‐Cheng; Gu, Xiao-Jie; Xiao, Pei

doi:10.1016/b978-0-08-100085-4.00006-2

Cited by 17 publications

(8 citation statements)

References 64 publications

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“…Papaver species contain alkaloids, phenolic compounds, and essential oil volatiles, among other components [ 49 ]. These classes found in different parts of the Papaver plants are discussed in the following subsections.…”

Section: Phytoconstituentsmentioning

confidence: 99%

Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications

Butnariu

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as ornamental plants. These plants are also valued in traditional medicine. Among all Papaver species, Papaver somniferum L. (opium poppy) is the most important species in supplying phytochemicals for the formulation of drugs, mainly alkaloids like morphine, codeine, rhoeadine, thebaine, and papaverine. In addition, Papaver plants present other types of phytochemicals, which altogether are responsible for its biological activities. Therefore, this review covers the phytochemical composition of Papaver plants, including alkaloids, phenolic compounds, and essential oils. The traditional uses are reviewed along with their pharmacological activities. Moreover, safety aspects are reported to provide a deep overview of the pharmacology potential of this genus. An updated search was carried out in databases such as Google Scholar, ScienceDirect, and PubMed to retrieve the information. Overall, this genus is a rich source of alkaloids of different types and also contains interesting phenolic compounds, such as anthocyanins, flavonols, and the characteristic indole derivatives nudicaulins. Among other pharmacological properties, numerous preclinical studies have been published about the analgesic, anticancer, antimicrobial, antioxidant, and antidiabetic activities of Papaver plants. Although it highlights the significant impact of this genus for the treatment of a variety of diseases and conditions, as a future prospect, characterization works accompanying preclinical studies are required along with clinical and toxicology studies to establish a correlation between the scientific and traditional knowledge.

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Section: Phytoconstituentsmentioning

confidence: 99%

Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications

Butnariu

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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show abstract

“…These alkaloids are renowned opium poppies with analgesic, cough suppressant, anticancer, and anti-in ammatory effects (Chaturvedi et al 2013;Guo et al 2018). Opium poppy is the only commercial source of morphine (Hao et al 2015). It was previously reported that in mature opium poppy plants, primary alkaloids accumulate in the capsule and stem (Beaudoin et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Differentially Expressed lncRNAs in Papaver somniferum L.

GÜRKÖK,

BUDAK,

GÜÇLÜ

2024

Preprint

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Long noncoding RNAs (lncRNAs) are essential for transcription and are involved in a wide range of biological processes in plants. Although lncRNAs have been identified in various plants, research on those linked to alkaloid biosynthesis in Papaver somniferum L. is limited. In this study, the expression of lncRNAs in two opium poppy cultivars that produce different major alkaloids (morphine and noscapine) were analysed. A total of 8945 lncRNAs, mainly lincRNAs, were characterized in the two cultivars' tissues and were distributed unevenly across opium poppy chromosomes. Tissue-specific expression profiles of lncRNAs were observed, with a greater number expressed in capsules than in stems, indicating potential effectiveness in capsules, particularly in Munich. Cis-target genes of DELs were detected in 51.8% and 92.4% of the DELs in Munich and HN1, respectively, and were positioned in coding gene-rich regions. A limited number of studies have indicated the potential roles of lncRNAs in secondary metabolite biosynthesis; 7 DELs targeting 12 genes in the BIA pathway, which are mainly involved in morphine biosynthesis, were predicted in Munich, while HN1 targeted 15 genes related to BIA biosynthesis. The F-box gene family abundance suggested potential roles in development, stress response, and secondary metabolism. GO and KEGG analyses suggested regulatory roles in secondary metabolite biosynthesis and starch/sucrose metabolism. This study highlights the potential regulatory roles of lncRNAs in the biosynthesis of secondary metabolites in opium poppy.

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“…Various types of alkaloids in plant families have different positions for the nitrogen atom. Some of the plant families are notably high in alkaloid content such as Papaveraceae, Solanaceae, Amaryllidaceae and other well-known families [ 1 , 2 ]. Opium poppy which is botanically known as Papaver somniferum belongs to the family Papaveraceae.…”

Section: Introductionmentioning

confidence: 99%

Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence

et al. 2023

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Papaver somniferum L. (Family: Papaveraceae) is a species well known for its diverse alkaloids (100 different benzylisoquinoline alkaloids (BIAs)). L-tyrosine serves as a precursor of several specific metabolites like BIAs. It has been used as an antitussive and potent analgesic to alleviate mild to extreme pain since ancient times. The extraction of pharmaceutically important alkaloids like morphine and codeine from poppy plant reflects the need for the most suitable and standard methods. Several analytical and extraction techniques have been reported in open literature for morphine, codeine and other important alkaloids which play a vital function in drug development and drug discovery. Many studies suggest that opioids are also responsible for adverse effects or secondary complications like dependence and withdrawal. In recent years, opium consumption and addiction are the most important risk factors. Many evidence-based reviews suggest that opium consumption is directly linked or acts as a risk factor for different cancers. In this review, we highlight significant efforts related to research which have been done over the past 5 decades and the complete information on Papaver somniferum including its phytochemistry, pharmacological actions, biosynthetic pathways and analytical techniques of opium alkaloid extraction and the link between opium consumption and cancer-related updates.

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Phytochemical and biological research of Papaver pharmaceutical resources

Cited by 17 publications

References 64 publications

Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications

Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications

Comprehensive Analysis of Differentially Expressed lncRNAs in Papaver somniferum L.

Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence

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