Phytochemical and biological research of Fritillaria medicinal resources

Hao, Da‐Cheng

doi:10.1016/b978-0-08-100085-4.00004-9

Cited by 5 publications

(8 citation statements)

References 70 publications

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“…Numbers in brackets mean the number of duplicated genes, e.g. 131 [18] means there were 131 total genes in the plastome, of which 18 were duplicated in the IRs. Numbers in parentheses mean the number of pseudogenes, e.g.…”

Section: Phylogenetic Analysesmentioning

confidence: 99%

“…The bulbs of Fritillaria have long been used as herbs in Asian countries, especially in traditional Chinese medicine, and are called "Bei-mu" in Chinese. The bulbs of Fritillaria are a botanical source for various pharmaceutically active components and have relieving cough, clearing heat, eliminating phlegm, analgesic and detoxifying effect, moreover, they have been used in some Chinese herbal formulations for treating cancers [18,19]. As the chemical compounds and pharmacological effects greatly differ among Fritillaria species [18], it is crucial to identify accurately them based on medicinal purpose.…”

Section: Introductionmentioning

confidence: 99%

“…The bulbs of Fritillaria are a botanical source for various pharmaceutically active components and have relieving cough, clearing heat, eliminating phlegm, analgesic and detoxifying effect, moreover, they have been used in some Chinese herbal formulations for treating cancers [18,19]. As the chemical compounds and pharmacological effects greatly differ among Fritillaria species [18], it is crucial to identify accurately them based on medicinal purpose. For this purpose, different barcoding such as plastid DNA (matK, rpl16, trnL-trnF) and nuclear DNA internal transcribed spacer (ITS), single nucleotide polymorphisms (SNPs) and genomic inter-simple sequence repeats (ISSRs) have been performed for identifying Fritillaria species [18,20].…”

Section: Introductionmentioning

confidence: 99%

“…As the chemical compounds and pharmacological effects greatly differ among Fritillaria species [18], it is crucial to identify accurately them based on medicinal purpose. For this purpose, different barcoding such as plastid DNA (matK, rpl16, trnL-trnF) and nuclear DNA internal transcribed spacer (ITS), single nucleotide polymorphisms (SNPs) and genomic inter-simple sequence repeats (ISSRs) have been performed for identifying Fritillaria species [18,20]. Fritillaria comprises eight subgenera which are supported by molecular phylogenetic analyses and these subgenera are all monophyletic except subgenus Fritillaria [17,21].…”

Section: Introductionmentioning

confidence: 99%

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Comparative chloroplast genomics of Fritillaria (Liliaceae), inferences for phylogenetic relationships between Fritillaria and Lilium and genome evolution

Huang

Yu²,

Liu

et al. 2019

Preprint

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Background Fritillaria is a genus consisting of about 140 species that has important medicinal and horticultural values. The monophyly of Fritillaria and phylogenetic relationships with Lilium were previously not fully resolved. The study involved the most comprehensive chloroplast genomes samples to date referring to Old and New World clades of Fritillaria as identified in earlier studies.Results We reported and compared eleven newly sequenced whole-plastome sequences of Fritillaria as well as characterization of SSRs and repeat sequence. These 11 plastomes proved highly similar in overall size (151,652-152,434bp), genome structure, gene content and order; Comparing them with other species of Liliales (6 out of 10 families) indicated the same similarity but showed some structural variations due to the contraction or expansion of the IR regions out or into of adjacent single-copy regions. A/T mononucleotides, palindromic and forward repeats were the most common types. Six hypervariable regions ( rps16 - trnQ, rbcL - accD, accD - psaI, psaJ - rpl33, petD - rpoA and rpl32 - trnL ) were discovered based on 26 Fritillaria whole-plastomes to be potential molecular markers. 26 species of Fritillaria plastomes and 21 species of Lilium plastomes were combined in a phylogenomic study with 3 Cardiocrinum species as out groups. Fritillaria was monophyly with moderate support as sister to Lilium based on 64 protein-coding genes (CDS) and the interspecific relationship within subgenus Fritillaria has strong resolution. The topology recovered from the whole plastome and single-copy gene data sets was the same as for coding gene data, but weak support for monophyly of Fritillaria .Conclusions The phylogenomic analysis reconstructed a topology that had some incongruences with previous studies. The six hypervariable regions can be used as candidate DNA barcodes for global genetic diversity detection of Fritillaria . The phylogenomic framework from this study can guide extensive genomic sampling to further discern the relationships among the Old and New World clades of Fritillaria and Lilium .

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Section: Phylogenetic Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative chloroplast genomics of Fritillaria (Liliaceae), inferences for phylogenetic relationships between Fritillaria and Lilium and genome evolution

Huang

Yu²,

Liu

et al. 2019

Preprint

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“…Studies on phytochemistry of BFC indicated that chemical components of BFC included steroidal alkaloids, saponins, terpenoids, glycosides, and many other compounds [ 4 ]. As revealed by modern studies, steroidal alkaloids were the major biological active compositions of BFC [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Extraction and Enrichment of Steroidal Alkaloids from Bulbs of CultivatedFritillaria cirrhosa

Wang

et al. 2014

BioMed Research International

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The bulbs of cultivated Fritillaria cirrhosa (BCFC) are used in China both for food and folk medicine due to its powerful biological activities. The aim of this study is to optimize the extraction and enrichment conditions of alkaloids from BCFC. Firstly, the orthogonal experimental design was used to optimize and evaluate four variables (ethanol concentration, solid-liquid ratio, extraction time, and temperature). Thereafter, resin adsorption was as a means to enrich alkaloids. Among 16 tested resins, H-103 resin presented higher adsorption capacity and desorption ratio. The equilibrium experimental data of the adsorption of total alkaloids, imperialine, and peimisine were well-fitted to the pseudo-first-order kinetics model, Langmuir and Freundlich isotherms models. Finally, in order to optimize the parameters for purifying alkaloids, dynamic adsorption and desorption tests were carried out. After one run treatment with H-103 resin, the contents of total alkaloids, imperialine, and peimisine in the product were 21.40-, 18.31-, and 22.88-fold increased with recovery yields of 94.43%, 90.57%, and 96.16%, respectively.

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A strategy for efficient enrichment of steroidal alkaloids from Fritillaria based on fluorinated reversed‐phase stationary phase

Zhou

et al. 2021

J of Separation Science

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Plant-derived alkaloids are bioactive natural ingredients, but their contents are relatively low in plants. Therefore, the efficient enrichment of alkaloids is a prerequisite for purification and further pharmacological research. In this study, an efficient and simple strategy for enrichment of steroidal alkaloids in Fritillaria was developed for the first time based on the fluorinated reverse-phase stationary phase (FC8HL). Superior selectivity between alkaloids and non-alkaloids was achieved in a non-aqueous system, and a simple solvent system containing low-

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Phytochemical and biological research of Fritillaria medicinal resources

Cited by 5 publications

References 70 publications

Comparative chloroplast genomics of Fritillaria (Liliaceae), inferences for phylogenetic relationships between Fritillaria and Lilium and genome evolution

Comparative chloroplast genomics of Fritillaria (Liliaceae), inferences for phylogenetic relationships between Fritillaria and Lilium and genome evolution

Optimization of Extraction and Enrichment of Steroidal Alkaloids from Bulbs of CultivatedFritillaria cirrhosa

A strategy for efficient enrichment of steroidal alkaloids from Fritillaria based on fluorinated reversed‐phase stationary phase

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