Phytochemical and chemotaxonomic study on Atractylodes lancea

Phytochemistry and Pharmacology of Sesquiterpenoids from Atractylodes DC. Genus Rhizomes

“…A phytochemical investigation of the rhizomes of A. macrocephala led to the isolation of four new sesquiterpenes, atractylmacrols B-E (57-60), as well as known eudesmane sesquiterpenes (61) through the interpretation of their NMR spectroscopic data and HREIMS values [54]. Eight eudesmane-type sesquiterpenoids (62)(63)(64)(65)(66)(67)(68)(69) were previously isolated from A. lancea with normal-phase and reverse-phase column chromatography and elucidated through detailed spectroscopic methods [55,56]. Xu et al [57] identified (2S,7R,10S)-3-hydroxylcarissone-11-O-β-D-glucopyranoside (70) and (2R,7R,10S)-3-hydroxylcarissone-11-O-β-D-glucopyranoside (71) in the rhizomes of A. lancea using extensive spectroscopic analyses with experimental and ECD calculations.…”

“…The atractyloside A (124), 10-epi-atractyloside A (125) (1S,4S,5S,7R,10R)-10,11,14-trihydroxyguai-3-one-11-O-β-D-glucopyranoside (126), (1S,4S,5R,7R,10R)-11,14-dihydroxyguai-3-one 11-O-β-D-glucopyranoside (127), atractyloside B (128), and (1S,5R,7R,10R)-secoatractylolactone-11-O-β-D-glucopyranoside (129) have been isolated and identified in A. macrocephala and A. lancea [17,42,55,66]. Phytochemical investigations of the rhizomes of A. lancea identified two previously described guaiane-type sesquiterpenes, namely (1S,4S,5R,7R,10S)-4,11,14-trihydroxyguai-3-one-11-O-β-D-glucopyranoside (130) and (1S,4S,5R,7R)-4,11,14-trihydroxyguaia-9-en-3-one-11-O-β-Dglucopyranoside (131), and the structures of the isolated compounds were elucidated using NMR spectroscopic analyses [67,68]. Three guaiane lactone glycosides have been identified and isolated from A. lancea via HPLC and elucidated through detailed spectroscopic methods, namely (1R,7R,10S)-10,11-dihydroxy-4-guaien-3-one 11-O-β-D-glucopyranoside (132), atractyloside A 14-O-β-D-fructofuranoside (133), and 1β,5α,7α-H-3β,4α,11,14-tetrahydroxyguaia-9-en-11-O-β-D-glucopyranoside (134) [53,69].…”

“…have been isolated and identified in A. macrocephala and A. lancea [17,42,55,66]. Phytochemical investigations of the rhizomes of A. lancea identified two previously described guaiane-type sesquiterpenes, namely (1S,4S,5R,7R,10S)-4,11,14-trihydroxyguai-3-one-11-O-β-D-glucopyranoside ( 130) and (1S,4S,5R,7R)-4,11,14-trihydroxyguaia-9-en-3-one-11-O-β-D-glucopyranoside (131), and the structures of the isolated compounds were elucidated using NMR spectroscopic analyses [67,68]. Three guaiane lactone glycosides have been identified and isolated from A. lancea via HPLC and elucidated through detailed spectroscopic methods, namely (1R,7R,10S)-10,11-dihydroxy-4-guaien-3-one 11-O-β-D-glucopyranoside (132), atractyloside A 14-O-β-D-fructofuranoside (133), and 1β,5α,7α-H-3β,4α,11,14-tetrahydroxy-guaia-9-en-11-O-β-D-glucopyranoside (134) [53,69].…”