Phytochemical and pharmacological evaluation of prop roots of Pandanus fascicularis Lam

Rajeswari, J.; Kesavan, Karthikeyan; Jayakar, B.

doi:10.1016/s1995-7645(11)60165-x

Cited by 13 publications

(9 citation statements)

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“…[2] Leaves of Pandanus plants contain alkaloids such as pandanamine, pandamerilactones with pyrroline derived structures as major chemical constituent [3] and was found to possess anti-oxidant, anti-inflammatory and anti-diabetic activities. [4][5][6] In ayurveda paste of P. odoratissimus with sugar is used for treating cancers. [7] Active principles of methanolic extract of whole plant are 3-(4-(dimethylamino)cinnamoyyl)-4-hydroxycomarin, 3,3'-methylenebis (4-hydroxycomarin), erythro-9,10-dihydroxyoctadecanoic acid, octadecanedioic acid and dihydroagathic acid.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anti-cancer potential of aqueous extract of Pandanus odoratissimus (Y.Kimura) Hatus. forma ferreus, by in vivo ascitic tumor model in swiss albino mice

Raja¹,

Varghese²,

Kotagiri³

et al. 2014

Phcog J.

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Background: India is a rich source of medicinal plants and number of plant extracts are used against diseases in various systems of medicine such as ayurveda, unani and siddha where only a few of them were scientifically explored. Objective: The objective of the present study was undertaken to perform dose dependent anti-cancer effect of aqueous and methanolic extracts of P. odoratissimus roots and leaves whose scientific documentation for anti-tumor agent is lacking despite using traditionally. Materials and Methods: The anti-cancer activity of methanolic extract of P. odoratissimus (MEPO) and aqueous extract of P. odoratissimus (AEPO) were tested against Ehrlich ascites carcinoma induced liquid tumors in swiss albino mice. The degree of protection was determined by change in body weight (gm), tumour volume (ml), packed cell volume (ml), cell viability (%), hematological parameters (R.B.C, W.B.C and hemoglobin content), mean survival time (MST), % increase in lifespan (% ILS) and histopathological observation of part of peritoneal layer. Results: The treatment with AEPO 400mg/kg, p.o. in EAC treated mice reduced tumor volume, packed cell volume, body weight, cell viability and improved all hematological parameters, mean survival time and life span. Histopathological changes showed degenerative changes of tumor cells in peritoneal layer. The anti-cancer effects of AEPO 400mg/kg, p.o. are equally more with that of the standard drug cisplatin. Conclusion:The results suggested that aqueous extract of roots and leaves of P. odoratissimus possess in vivo anti-cancer activity comparable to cisplatin and this study scientifically validated the traditional use of this plant. Keywords INTRODUCTIONThere is a growing interest in the pharmacological evaluation of various plants used in indian traditional systems of medicine. Pandanus odoratissimus (Pandanaceae) is one of such plants, distributed commonly throughout india. In ayurveda, unani and siddha the leaves are used for treating back ache, rheumatic diseases, epilepsy, wound healing, nervous disorders, loss of appetite, indigestion, constipation, diabetes, infertility, skin diseases, urinary disorders and fever.[1] The plant is known to possess a broad spectrum of medicinal, pharmacological and therapeutic properties. Tribals believe that this herb is an effective remedy for wide range of illnesses.[2]Leaves of Pandanus plants contain alkaloids such as pandanamine, pandamerilactones with pyrroline derived structures as major chemical constituent [3] and was found to possess anti-oxidant, anti-inflammatory and anti-diabetic activities. [4][5][6] In ayurveda paste of P. odoratissimus with sugar is used for treating cancers.[7] Active principles of methanolic extract of whole plant are 3-(4-(dimethylamino)cinnamoyyl)-4-hydroxycomarin, 3,3'-methylenebis (4-hydroxycomarin), erythro-9,10-dihydroxyoctadecanoic acid, octadecanedioic acid and dihydroagathic acid. [8] Recently, the acute and subacute toxicological studies on methanolic extract of P. odoratissimus did no...

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Section: Introductionmentioning

confidence: 99%

Evaluation of anti-cancer potential of aqueous extract of Pandanus odoratissimus (Y.Kimura) Hatus. forma ferreus, by in vivo ascitic tumor model in swiss albino mice

Raja¹,

Varghese²,

Kotagiri³

et al. 2014

Phcog J.

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“…Microscopic method is one of the simplest and cheapest methods to start with for establishing the correct identity of the source materials. [2223242526] The pharmacognostic standards and phytochemical screening for leaves of Z. xylopyrus have been carried out in an extensive way in this study. The macroscopic characters of leaves can serve as diagnostic parameters.…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostical and phytochemical evaluation of the leaves of Ziziphus xylopyrus (Retz) Willd

Gandagule¹,

Basavan²,

Zalke³

et al. 2013

Ancient Sci Life

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Background:The fruit decoction of Ziziphus xylopyrus (Retz) Willd. is used toward increase sterility in woman intended birth control in some parts of Rajasthan, India. This plant is widely used in Turkish medicines as a potent sedative. One to two inches of the fresh stem bark of this species are chewed with 1-2 peppers, and the sap swallowed once a day for 5 days in the treatment of cough. Standardization is one of the challenges in herbal medicine. It is essential to evaluate the herbal plants scientifically and proper documentation should be made to know their medicinal properties.Materials and Methods:Leaf samples of Z. xylopyrus were studied as recommended by World Health Organization for morphological, microscopic, physicochemical, phytochemical, powder characteristics and other methods for standardization.Results:Morphologically the leaves are obovate or orbicular in shape, pinnate venation having aromatic odour and pungent taste. Microscopically leaves showed the presence of ground tissue, vascular strand, xylem and phloem. The crystals are mostly rosette type. Microscopic examination of powder showed the presence of stomata, covering trichomes, sclerenchyma, collenchyma, epidermal cells and vascular strands. Phytochemical screening of the plant part with various solvents revealed the presence of alkaloids, carbohydrates, steroids and sterol, glycosides, saponins, flavonoids, phenolic compounds, triterpenoids in it. Physicochemical parameters such as ash value extractive values were also determined and results showed that water soluble extractive value to be higher than alcohol soluble extractive value.Conclusion:Results may be helpful for further confirmation of selected species and in future these characters may be compared with the new batch of the same plant materials.

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“…P. fascicularis is distributed mainly in subtropical and tropical regions, is native to South Asia, and, in particular, has a significant presence in mangrove swamps (Loa et al, 2016; Vinod et al, 2007; Vinod et al, 2010). The leaves of P. fascicularis are useful in edema, tumor, leprosy, antispasmodic, inflammation, pain, and rheumatoid arthritis applications (Panda et al, 2008; Rajeswari et al, 2011). However, the inhibitory effects of P. fascicularis Lam on pro-inflammatory cytokines production have not yet been examined.…”

Section: Introductionmentioning

confidence: 99%

Pandanus fascicularis Lam Extract Inhibits Pro-Inflammatory Cytokines Production in LPS-Stimulated RAW 264.7 Cells

Shim

2019

pnf

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Pandanus fascicularis Lam has been shown to exert to a variety of physiological effects on edema, tumors, leprosy, spasm, inflammation, pain, and rheumatoid arthritis. In this study, the effects of a P. fascicularis extract on the production of lipopolysaccharide (LPS)-induced pro-inflammatory cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α expression and on the production of the inflammatory mediator, nitric oxide (NO), in RAW 264.7 cells were examined. The P. fascicularis extract decreased LPS-induced NO production. Moreover, enzyme-linked immunosorbent assays revealed that the P. fascicularis extract concentration-dependently suppressed LPS-induced production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. These results suggest that the P. fascicularis extract has potential as an anti-inflammatory therapeutic substance for use in the prevention of the inflammatory disorder.

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Phytochemical and pharmacological evaluation of prop roots of Pandanus fascicularis Lam

Abstract: The extracts of prop roots of P. fascicularis produce significant analgesic and anti-inflammatory activities, supporting the traditional application of this herb in treating various diseases associated with inflammation and pain.

Cited by 13 publications

References 14 publications

Evaluation of anti-cancer potential of aqueous extract of Pandanus odoratissimus (Y.Kimura) Hatus. forma ferreus, by in vivo ascitic tumor model in swiss albino mice

Evaluation of anti-cancer potential of aqueous extract of Pandanus odoratissimus (Y.Kimura) Hatus. forma ferreus, by in vivo ascitic tumor model in swiss albino mice

Pharmacognostical and phytochemical evaluation of the leaves of Ziziphus xylopyrus (Retz) Willd

Pandanus fascicularis Lam Extract Inhibits Pro-Inflammatory Cytokines Production in LPS-Stimulated RAW 264.7 Cells

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