2015
DOI: 10.1002/ptr.5303
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Phytochemical and Pharmacological Profile of Vitex negundo

Abstract: The article aims to review all the chemical constituents and pharmacological properties of Vitex negundo L. (Verbenaceae) (VN). VN is an important medicinal plant used as reputed herbal medicine with versatile pharmacological activities in China, India and Japan. A total of 104 referred articles about VN were compiled from major databases and academic publishers, such as MEDLINE, Pubmed, Scholar, Elsevier, Springer, Wiley and CNKI. As a result, a total of 120 compounds isolated from VN can be divided mainly in… Show more

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Cited by 50 publications
(28 citation statements)
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“…Vitex negundo L (Verbenaceae) is an aromatic shrub that is abundant in Asian countries [ 13 ]. Recently, a series of compounds from Vitex negundo have been used in traditional Chinese medicine for the treatment of various diseases [ 14 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…Vitex negundo L (Verbenaceae) is an aromatic shrub that is abundant in Asian countries [ 13 ]. Recently, a series of compounds from Vitex negundo have been used in traditional Chinese medicine for the treatment of various diseases [ 14 17 ].…”
Section: Introductionmentioning
confidence: 99%
“… Neelkanthi (A), Small-flowered Bugleweed (E), Bishkopra (L) Herb (W/C)/whole plant Ajugarin I, deoxyajugarin I, ajugarin I, chlorohydrin, 3β-acetoxy-clerodinin C [ 49 ] Half teaspoon of the powder of A. parviflora leaves, Aconitum heterophyllum tuber and Podophyllum hexandrum roots is given twice a day in the morning and at night after meals up to 3 months Ethanol extract of the whole plant showed in vitro inhibitory effect on alpha-amylase with an IC 50 value of 110.18 µg/mL. In addition, the extract (60 mg/kg) showed anti-diabetic by reducing blood sugar level and body weight in ALX-induced diabetic rats [ 50 ] Vitex negundo L. Nirgundi (S/H), Five-leaved chaste (E), Shimaloo/Somi (L) Shrub (W)/whole plant Casticin, isoorientin, chrysophenol D, luteolin, essential oil (mainly contains sabinene, linalool, terpinen-4-ol, β-caryophyllene, α-guaiene and globulol) [ 51 ] The decoction of the whole plant is taken twice a day after meal (1) A crude polysaccharide fraction (50 mg/kg) isolated from the leaves reduced food intake, body weight and fasting glucose levels in db/db mice in a 7 days study [ 52 ] (2) An iridoid glucoside (50 mg/kg) isolated from V. negundo leaves reduced the levels of plasma glucose, glycosylated haemoglobin and increased in the levels of insulin and haemoglobin in STZ induced diabetic rats in a 30 days study when compared with the glibenclamide (5 mg/kg) which was used as a positive control. Besides, it increased glycolytic enzymes level and glycogen content and decreased the levels of gluconeogenic enzymes in the liver of diabetic rats [ 53 ] Leguminosae Bauhinia variegata L. Kachnara (S), Kachnar (H), Camel’s foot tree (E) Tree (W/C)/stem bark and flowers Naringenin, quercetin 3-methyl ether, luteolin, rutin, isoquercitrin, daucosterol, 2′-hydroxy4′,6′-dimethoxy-3,4-methylenedioxy chalcone, kaempferol-3- O -glucoside [ 54 ] About 10 mL of the bark juice (overnight soaked with water) is taken in the morning before a meal Aqueous leaves extract (500 and 1000 mg/kg) decreased plasma glucose, cholesterol, triglyceride, creatinine and blood urea nitrogen level of both type 1 and type 2 diabetes in high-fat diet and STZ induced diabetic rats in a 28 days study.…”
Section: Resultsmentioning
confidence: 99%
“…Extensive experiments, including two-dimensional NMR, will be carried out to fully characterise this plant's natural metabolite. Review papers were consistently published to justify the non-exhaustive exploration of this genus, both phytochemically and biologically [19][20][21]. On another note, such instant lemuni rice preparation will hopefully promote Vitex consumption among busy locals.…”
Section: Resultsmentioning
confidence: 99%