Phytochemical and Pharmacological Profile of Leucas lavandulaefolia: A review

Makhija, I.K.; Chandrashekar, K. S.; Richard, L.; Jaykumar, B.

doi:10.3923/rjmp.2011.500.507

Cited by 10 publications

(11 citation statements)

References 3 publications

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“…The secondary metabolites isolated from L. lavandulaefolia exhibited antimicrobial activity that supports folkloric use in the treatment of some diseases as broad-spectrum antimicrobial agents. The presence of flavonoids and phenolic compounds in L. lavandulaefolia could account for its antimicrobial activity was in accordance with the results previously obtained 4 .…”

Section: Antimicrobial Activities Of the Isolated Secondary Metabolitsupporting

confidence: 92%

“…To assess the potential role of secondary metabolites in nonhost resistance L. lavandulaefolia was tested for the motility behaviour of A. cochlioides zoospores. Because this plant extract showed the antimicrobial activity against different microoganisms 4 . Isolation of A. cochlioides zoospores regulating principles from nonhost plants may result in interesting compounds for developing an effective control strategy to contest.…”

Section: Aphanomycesmentioning

confidence: 97%

“…Based on these we isolated biologically active secondary metabolites from L. lavandulaefolia that showed the attractant and halting activity toward A. cochlioides zoospores. The antimicrobial activity of this plant extract against different microorganisms has already been reported, although the compounds, which possess antimicrobial activity, have not been identified 4 .…”

Section: Aphanomycesmentioning

confidence: 98%

“…The anti-inflammatory activities of the extract of L. lavandulaefolia were reported 4 . The plant extract is employed locally in cough and this could probably be attributed to its antitussive activity 4 .…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…The phytochemical composition of L. lavandulaefolia reported in the literature indicates the presence of acacetin, chrysoeriol, linifoliside, linifoliol, alkaloids triterpenoids, steroids and fatty alcohols in methanol extracts, lupeol and taraxerone 4 . Philomina and Rao identified toxic principals (caffeic acid, chlorogenic acid phydroxybenzoic acid, p-coumaric acid, vanillic acid) from the leaves of L. lavandulaefolia 6 .…”

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The investigation of terrestrial plants origin aimed at searching new natural biologically active compounds is a central issue of this kind of studies, through structure elucidation combined with biological tests. We investigated the biologically active secondary metabolites from Leucas lavandulaefolia towards various effects on the behavior of Aphanomyces cochlioides zoospores and with antimicrobial activity. We purified the following compounds acacetin, chrysoeriol, luteolin, acacetin 7-O-β-D-glucuronide, acetoside, isoacetoside, salicylic acid and caffeic acid. Their structures were elucidated by spectroscopic analyses and compared with those of the reported data. Five compounds (luteolin, acacetin 7-O-β-D-glucuronide, acetoside, isoacetoside, and salicylic acid) were isolated from L. lavandulaefolia for the first time ever. It was found that luteolin showed a strong attractant and encystment activity toward zoospores of the phytopathogenic fungus A. cochlioides zoospores. Chrysoeriol also showed an attractant activity towards A. cochlioides zoospores. This is the first research report of L. lavandulaefolia regarding zoospores bioassay. Antibacterial assay on these compounds indicated that they have antimicrobial activity against the tested bacteria Bacillus subtilis and Staphylococcus aureus. Some of the identified secondary metabolites provided the evidence for the traditional usage of the plants as different therapeutic potentials (anti-inflammatory, antitussive and anti-diabetes) and may be useful for developing an effective control strategy to contest. INTRODUCTION: Leucas lavandulaefolia Ress. (Family-Labiatae) Syn. Leucas linifolia spreng is a well-known traditional medicinal plant widely distributed throughout South East Asia, Africa 1. It is an herbaceous annual weed, which grows abundantly in fields, pastures, roadsides and waste lands. It is erect, slightly pubescent or tomentose, 0.3 to 0.75 m in height, usually branched; branches are quadrangular, pubescent. Flowers are sub sessile or shortly pedicellate, in axillary and terminal whorls 1.3 to 2 cm diameter 1.3 to 2 cm diameter, toward the end of the branches 2 .

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Section: Antimicrobial Activities Of the Isolated Secondary Metabolitsupporting

confidence: 92%

Section: Aphanomycesmentioning

confidence: 97%

Section: Aphanomycesmentioning

confidence: 98%

Section: Pharmacological Propertiesmentioning

confidence: 99%

mentioning

confidence: 98%

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