Phytochemical and Pharmacological Profiles of the Genus Odontonema (Acanthaceae)

Luhata, Lokadi Pierre; Munkombwe, Namboole Moses; Cheuka, Peter Mubanga; Harrison, Sikanyika

doi:10.9734/bjpr/2016/29877

Cited by 4 publications

(4 citation statements)

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“…The signals/chemical shifts of the whiteyellow isolate were recorded successfully based on 1, 2-dimensional NMR spectroscopy. The NMR experimental values of stigmasterol are in agreement with the ones reported by [23,24] as compared in Table 3.…”

Section: Phytochemical Screening and Physical Characterizationsupporting

confidence: 90%

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Phytochemical Analyses of Terminalia Schimperiana (combretaceae) Root Bark Extract to Isolate Stigmasterol

Khan¹,

Bala²,

Maliki³

2019

Adv. J. Chem. A

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Section: Phytochemical Screening and Physical Characterizationsupporting

confidence: 90%

“…The chemical shift assignments were made on the basis of the information obtained from 1 H-NMR, 13 C-NMR, COSY, HSQC, HMBC and comparison of the data with those reported for the corresponding triterpenes [23,24].…”

Section: Phytochemical Screening and Physical Characterizationmentioning

confidence: 99%

Phytochemical Analyses of Terminalia Schimperiana (combretaceae) Root Bark Extract to Isolate Stigmasterol

Khan¹,

Bala²,

Maliki³

2019

Adv. J. Chem. A

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“…The 1 H NMR spectral data displayed a smaller J value of 7.6 Hz between protons H-2 and H-3 suggesting their monoaxial (cis) configuration and thus the absolute configuration in compound 4 could be (2R,3R) or (2S,3S). 22 Furthermore, Gaffield 21 reported that, in the CD spectrum The known compounds were identified as volkensiflavone (5) [24][25][26] , morelloflavone (6), 2,4,15,27 volkensiflavone-7-O--glucopyranoside (7), 17 morelloflavone-7-O--glucopyranoside (8), 2,17 (-)-catechin (9), 28 1,5-dihydroxyxanthone (10), 5,9 1,7-dihydroxyxanthone (11), 2,3,29 allanxanthone A (12), 5 6-deoxyisojacareubin (13), 3 hydrocotoin (14), 4 betulinic acid (15) 30 an inseparable mixture of -sitosterol and stigmasterol 31 and, an inseparable mixture of -sitosteryland stigmasteryl-3-O--glucopyranosides. 5 The absolute configurations of compounds 5-8 were determined as (2R,3S), (2R,3S), (2S,3R) and (2S,3R) respectively.…”

Section: Resultsmentioning

confidence: 99%

Two xanthones and two rotameric (3⟶8) biflavonoids from the Cameroonian medicinal plant Allanblackia floribunda Oliv. (Guttiferae)

Mountessou

Tchamgoue

Dzoyem

et al. 2018

Tetrahedron Letters

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Two xanthones, 2-(3-hydroxy-3,3-dimethyldihydroallyl)-dihydro-6-deoxyisojacareubin (1) and dihydro-6-deoxyjacareubin (2), and two 3⟶8 rotameric biflavonoids, (2R,3S)volkensiflavone-7-O--acetylglucopyranoside (3) and (2S,3S)-morelloflavone-7-O-acetylglucopyranoside (4), together with fifteen known compounds, were isolated from a dichloromethane/methanol (1/1, v/v) extract of the bark of the plant Allanblackia floribunda. The structures of the new compounds were elucidated by NMR spectroscopy and mass spectroscopic techniques and those of the known ones were deduced by comparison with data reported in the literature. The isolated biflavonoids were obtained as mixtures of conformers exhibiting duplicate NMR signals in solution at 25 °C and their respective absolute configurations were assigned using circular dichroism spectroscopy. Some of the isolated compounds were assessed for their antibacterial and antioxidant properties.

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“…The family contains more than 4,000 species, which are mostly herbs, shrubs or climbers and rarely trees. 1 The family is rich in secondary metabolites that have been used traditionally by the local community against various ailments such as anti-hypertensive properties. 2 The phytochemical family has many biological properties such as antiplasmodial, anti-HIV, 3 antihypertensive, 4 antifungal 5 and anticancer.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic, in vitro Enzyme Inhibitory Potential and Phytochemical Profiling of Odontonema strictum

Nadeem

Khan

Koala

et al. 2023

Pharmacognosy Magazine

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Background Odontonema strictum is an herbaceous plant, indigenous to Central America and Central Africa, and has been used traditionally by the local community against various ailments. The current piece of work was carried out to evaluate the cytotoxic potential of O. strictum by using brine shrimp lethality and the in vitro cytotoxicity/viability assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide [MTT]), as well as the in vitro enzyme inhibitory potential by using alpha-amylase, protein kinase enzymes and phytochemical analysis of the different extracts of aerial parts of O. strictum. Materials and Method Extracts of aerial parts of O. strictum were prepared through the successive extraction method using solvents with the order of polarity as n-hexane, dichloromethane, ethyl acetate, methanol and water. Cytotoxicity was assessed through brine shrimp lethality assay and in vitro cell viability assay (MTT), whereas enzyme inhibition potential was evaluated through Alpha-amylase and protein kinase assay. Phytochemical analysis was done by assessing the total phenolic and total flavonoid contents of both leaves and flowers. Results All the extracts exhibited various phytochemical and biological activities. Remarkable toxicity profiles against the brine shrimp lethality assay (LD50:11.5 µg/mL) were shown by the leaf extracts, whereas both leaves and flowers exhibited promising anti-proliferative activity, assessed by the MTT assay. Significant alpha-amylase and protein kinase inhibition potential were manifested by leave extracts with IC50:195.6 µg/mL and minimum inhibitory concentration (MIC): 16.3 µg/mL respectively. The phytochemical analysis of the plant showed that it was sufficiently rich in phenolic compounds with a total phenolic content and total flavonoid content (96.8 µg GAE/mg and 65.1 µg QE/mg, respectively). Conclusion It is plausible to believe that the cytotoxic and enzymatic activity of the aerial parts of O. strictum aerial parts might be, at least partly, to the presence of phenolic chemicals and could be a possible source of cytotoxic agent and an enzyme inhibitor.

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Phytochemical and Pharmacological Profiles of the Genus Odontonema (Acanthaceae)

Cited by 4 publications

References 0 publications

Phytochemical Analyses of Terminalia Schimperiana (combretaceae) Root Bark Extract to Isolate Stigmasterol

Phytochemical Analyses of Terminalia Schimperiana (combretaceae) Root Bark Extract to Isolate Stigmasterol

Two xanthones and two rotameric (3⟶8) biflavonoids from the Cameroonian medicinal plant Allanblackia floribunda Oliv. (Guttiferae)

Cytotoxic, in vitro Enzyme Inhibitory Potential and Phytochemical Profiling of Odontonema strictum

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