Phytochemical and pharmacological properties of essential oils fromCedrusspecies

Abstract

Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer patients frequently seek remedies from traditional medicinal plants that are believed to exert less side effects than conventional therapy with synthetic drugs. A long-lasting goal of anti-cancer and anti-microbial therapy research is to find compounds with reduced side effects compared to currently approved drugs. In this respect, Cedrus species might be of interest. The essential oil isolated from Cedrus libani leaves may bear potential for drug development due to its high concentrations of germacrene D and β-caryophyllene. The essential oils from Cedrus species also show bioactivity against bacteria and viruses. More preclinical analyses (e.g. in vivo experiments) as well as clinical trials are required to evaluate the potential of essential oils from Cedrus species for drug development.

A computational approach for rational discovery of inhibitors for non-structural protein 1 of SARS-CoV-2

“…Natural and novel molecules as inhibitors of SARS-CoV-2 are also being examined by practicing in-silico approaches [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. In earlier studies, Himachalenes scaffolds were recognized for their anti-inflammatory and antiviral activities [ 24 , 25 , 26 ]. A polymer-stabilized Pd(0) nanoparticle-catalyzed Suzuki-Miyaura crosscoupling reaction of amino vinyl bromide substituted benzosuberenes were used for aminoarylbenzosuberenes (AABs) synthesis [ 27 ].…”

Cedrus atlantica Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: In Vitro and In Vivo Studies

“…The essential oils from Cedar species, including Cedrus atlantica in Morocco and Algeria, Cedrus deodara in the Himalayan Mountains and Cedrus libani in Lebanon, Syria and Turkey have been traditionally used in aromatherapy to improve health with respect to the cutaneous, musculoskeletal, and genitourinary systems [17]. Recent evidence suggests that Cedrus species oils have multiple biological activities, such as anti-inflammatory, antibacterial, antioxidant, analgesic and anti-cancer effects [18][19][20]. Cedrus atlantica (CAt) was introduced to Europe and the U.S.A in the mid-19th century and has been used in forestation and tree planting operations [21].…”

Review on essential oils, chemical composition, extraction, and utilization of some conifers in Northwestern Himalayas

“…Cedrus deodara Needle α-Terpineol, limonene, linalool, Anethole, Caryophyllene, α-Caryophyllene, eugenol, Estragole, Trans-anethole, ρ-Anisaldehyde, Eugenyl acetate, β-Myrecene, α-Bisabolol, β-Pinene, α-Pinene, 3-Carene, eucalyptol, Cubebene, α-Muurolene, β-Cadinene, Eugenyl acetate, Aromadendrene oxide-(2), methyl palmitate (Saab et al, 2018;Sharma et al, 2017;Zeng, Zhang, Gao, Jia, & He, 2012) T A B L E 1 (Continued)…”