Phytochemical and pharmacological properties of asperuloside, a systematic review

Manzione, Maria Giulia; Martorell, Miquel; Sharopov, Farukh; Bhat, Namrata Ganesh; N, Anil Kumar; Fokou, Patrick Valère Tsouh; Pezzani, Raffaele

doi:10.1016/j.ejphar.2020.173344

Cited by 23 publications

(16 citation statements)

References 48 publications

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“…11-keto-β-boswellic acid is a triterpenoid found in Boswellia serrata and has potential therapeutic efficacy against several chronic inflammatory diseases and neurodegenerative diseases [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Asperuloside, which is classified under the category of iridoid glycosides, has potential for the treatment of obesity, inflammatory diseases, cancer, bacterial infection, and renal fibrosis [ 61 , 62 , 63 , 64 , 65 , 66 ]. Echinatin, as a bioactive flavonoid of Glycyrrhiza plants, displays antioxidant and anti-inflammatory activities [ 36 , 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects

Cheng

Zhou

et al. 2022

Molecules

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As cannabinoid CB2 receptors (CB2R) possess various pharmacological effects—including anti-epilepsy, analgesia, anti-inflammation, anti-fibrosis, and regulation of bone metabolism—without the psychoactive side effects induced by cannabinoid CB1R activation, they have become the focus of research and development of new target drugs in recent years. The present study was intended to (1) establish a double luciferase screening system for a CB2R modulator; (2) validate the agonistic activities of the screened compounds on CB2R by determining cAMP accumulation using HEK293 cells that are stably expressing CB2R; (3) predict the binding affinity between ligands and CB2 receptors and characterize the binding modes using molecular docking; (4) analyze the CB2 receptors–ligand complex stability, conformational behavior, and interaction using molecular dynamics; and (5) evaluate the regulatory effects of the screened compounds on bone metabolism in osteoblasts and osteoclasts. The results demonstrated that the screening system had good stability and was able to screen cannabinoid CB2R modulators from botanical compounds. Altogether, nine CB2R agonists were identified by screening from 69 botanical compounds, and these CB2R agonists exhibited remarkable inhibitory effects on cAMP accumulation and good affinity to CB2R, as evidenced by the molecular docking and molecular dynamics. Five of the nine CB2R agonists could stimulate osteoblastic bone formation and inhibit osteoclastic bone resorption. All these findings may provide useful clues for the development of novel anti-osteoporotic drugs and help elucidate the mechanism underlying the biological activities of CB2R agonists identified from the botanical materials.

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Section: Discussionmentioning

confidence: 99%

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects

Cheng

Zhou

et al. 2022

Molecules

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“…Such compound has already been reported in some Galium species [ 37 , 45 ] but never in G. arenarium . It has been related to a number of pharmacological properties as an anticancer [ 46 ], anti-inflammatory and anti-obesity [ 47 ], anti-viral, anti-malarial, anti-protozoal, anti-hypertensive, immunomodulatory, and antioxidant agent [ 48 ]. Therefore, we suggest that the abundance of this iridoid is responsible for the very strong antioxidant and anti-inflammatory activities of the MeOH 40 fraction.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antioxidant, Anti-Inflammatory and Cytoprotective Activities of Halophyte Extracts against Mycotoxin Intoxication

Hymery

Dauvergne²,

Boussaden³

et al. 2021

Toxins

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Twelve halophyte species belonging to different families, widely represented along French Atlantic shoreline and commonly used in traditional medicine, were screened for protective activities against mycotoxins, in order to set out new promising sources of natural ingredients for feed applications. Selected halophytic species from diverse natural habitats were examined for their in vitro anti-mycotoxin activities, through viability evaluation of Madin-Darby Bovine Kidney (MDBK) and intestinal porcine enterocyte (IPEC-J2) cell lines. Besides, the in vitro antioxidant activities of plant extracts were assessed (total antioxidant and 2,2-diphenyl-1-picrylhydrazyl (DPPH)-scavenging bioassays). Of the 12 species, Galium arenarium, Convolvulus soldanella and Eryngium campestre exhibited the most protective action on MDBK and IPEC-J2 cells against zearalenone (ZEN) or T2 toxin contamination (restoring about 75% of cell viability at 10 μg·mL−1) without inflammation response. They also had strong antioxidant capacities (Inhibitory concentration of 50% (IC50) < 100 μg·mL−1 for DPPH radical and total antioxidant capacity (TAC) of 100 to 200 mg Ascorbic Acid Equivalent (AAE)·g−1 Dry Weight), suggesting that cell protection against intoxication involves antioxidant action. A bio-guided study showed that fractions of G. arenarium extract protect MDBK cells against T2 or ZEN toxicity and several major compounds like chlorogenic acid and asperuloside could be involved in this protective effect. Overall, our results show that the halophytes G. arenarium, C. soldanella and E. campestre should be considered further as new sources of ingredients for livestock feed with protective action against mycotoxin intoxication.

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“…In the Rubiaceae, the organic polar and mid-polar extracts of Guettarda speciosa L., Hydnophytum formicarum Jack, Morinda citrifolia L., and Myrmecodia tuberosa Jack, and Guettarda speciosa L. are antibacterial and antifungal [ 82 , 225 , 226 , 227 , 228 ] ( Table S2 ) [ 81 , 162 , 229 , 230 , 231 ]. Plants in this family yield antimicrobial water soluble iridoid glycosides such as in loganic acid ( 67 ) from G. speciosa, which strongly repressed HCV [ 228 ], and asperuloside ( 68 ) from M. citrifolia ( Table S2 ) [ 77 , 91 , 93 , 220 , 232 , 233 , 234 ]. Other antimicrobial principles are caffeic acid derivatives including the antiviral 4,5-di- O -caffeoylquinic acid ( 69 ) [ 229 , 235 ] as well as 5 ,4′-dihydroxy-6,7,8,-trimethoxyflavone ( 70 ) in Gardenia lucida Roxb .…”

Section: Distribution Of Antibacterial Antifungal and Antiviral Princ...mentioning

confidence: 99%

“…Other antimicrobial principles are caffeic acid derivatives including the antiviral 4,5-di- O -caffeoylquinic acid ( 69 ) [ 229 , 235 ] as well as 5 ,4′-dihydroxy-6,7,8,-trimethoxyflavone ( 70 ) in Gardenia lucida Roxb . [ 91 , 234 , 236 ], antimycobacterial monoterpene indole alkaloids [ 230 ], the chalcone butein ( 71 ) from H. formicarum [ 22 ] ( Table S2 ) [ 88 , 237 ], and the anthraquinones damnacanthal ( 72 ) and 1,3-dihydroxy-5-methoxy-2,6-bismethoxymethyl-9,10-anthraquinone [ 233 ] ( Table S2 ) [ 81 , 229 , 230 , 232 ]. ( E )-phytol ( 73 ) is strongly antimycobacterial [ 232 ].…”

Section: Distribution Of Antibacterial Antifungal and Antiviral Princ...mentioning

confidence: 99%

Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific

et al. 2022

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Microbes such as the White Spot Syndrome Virus account for severe losses in the shrimp farming industry globally. This review examines the literature on the mangrove plants of Asia and the Pacific with antibacterial, antifungal, or antiviral activities. All of the available data published on this subject were collected from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1968 to 2022. Out of about 286 plant species, 119 exhibited antimicrobial effects, and a total of 114 antimicrobial natural products have been identified including 12 with MIC values below 1 µg/mL. Most of these plants are medicinal. The mangrove plants of Asia and the Pacific yield secondary metabolites with the potential to mitigate infectious diseases in shrimp aquaculture.

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Phytochemical and pharmacological properties of asperuloside, a systematic review

Cited by 23 publications

References 48 publications

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects

Evaluation of the Antioxidant, Anti-Inflammatory and Cytoprotective Activities of Halophyte Extracts against Mycotoxin Intoxication

Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific

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