Phytochemical and pharmacological properties of the genus <i>Alpinia</i> from 2016 to 2023

Youn, Isoo; Han, Ah-Reum; Piao, Donglan; Lee, Hwaryeong; Kwak, Hyunkyung; Lee, Yeju; Nam, Joo-Won; Seo, Eun Kyoung

doi:10.1039/d4np00004h

Nat. Prod. Rep.

2024

DOI: 10.1039/d4np00004h

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Phytochemical and pharmacological properties of the genus Alpinia from 2016 to 2023

Isoo Youn,

Ah-Reum Han,

Donglan Piao

et al.

Abstract: Alpinia is the largest genus in the ginger family, Zingiberaceae, and comprises about 500 species. It is known to have various secondary metabolites and biological properties on account of those metabolites.

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References 169 publications

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LC-HRMS/MS-Guided Isolation of Unusual Diarylheptanoids from the Rhizomes of Alpinia officinarum

Cho,

Kim,

Han

et al. 2024

ACS Omega

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LC-HRMS/MS analysis facilitated the precise targeting, isolation, and identification of unusual dimeric diarylheptanoids from Alpinia officinarum (A. officinarum). The tandem MS data for (4E)-1,7-diphenyl-4-hepten-3-one (7) revealed fragment ions at m/z 91, 105, and 117, which are fragmentation patterns specific to diarylheptanoids. In the tandem MS data, peaks with m/z values ranging from 450 to 600 that exhibited these specific fragment ions were selected and isolated. Consequently, two previously undescribed dimeric diarylheptanoids (1 and 2) and four unusual diarylheptanoids (3−6) along with 10 monomeric diarylheptanoids (7−16) were isolated from the rhizomes of A. officinarum using various chromatographic techniques. The structures of the isolates were elucidated by an analysis of 1D/2D NMR and HRESIMS data, and a combination of DP4+ probability analysis and ECD calculations. To evaluate the anti-inflammatory effects of the isolated compounds, their inhibitory activity against nitric oxide production in LPS-induced RAW 264.7 cells was assessed. Compounds 1, 7, and 9 exhibited remarkable inhibitory effects with IC 50 values of 14.7, 6.6, and 5.0 μM, respectively.

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LC-HRMS/MS-Guided Isolation of Unusual Diarylheptanoids from the Rhizomes of Alpinia officinarum

Cho,

Kim,

Han

et al. 2024

ACS Omega

View full text Add to dashboard Cite

show abstract

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Phytochemical and pharmacological properties of the genus Alpinia from 2016 to 2023

Abstract: Alpinia is the largest genus in the ginger family, Zingiberaceae, and comprises about 500 species. It is known to have various secondary metabolites and biological properties on account of those metabolites.

Cited by 1 publication

References 169 publications

LC-HRMS/MS-Guided Isolation of Unusual Diarylheptanoids from the Rhizomes of Alpinia officinarum

LC-HRMS/MS-Guided Isolation of Unusual Diarylheptanoids from the Rhizomes of Alpinia officinarum

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