PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF Vernonia amygdalina: A REVIEW

Alara, Oluwaseun Ruth; Abdurahman, Nour Hamid; Mudalip, Siti Kholijah Abdul; Olalere, Olusegun Abayomi

doi:10.15282/jceib.v2i1.3871

Cited by 55 publications

(49 citation statements)

References 42 publications

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“…Vernonia amygdalina and CO leave extracts have been reported to be rich in antioxidant and flavonoids. (17,18) The high antioxidant levels present in the extracts may act in synergy with other phytochemicals which activate endothelial cells to synthesize tissue factors thus promoting haemostasis. Plant extracts are administered to humans in uncontrolled doses by the ethnomedical practitioners.…”

Section: Discussionmentioning

confidence: 99%

Haemostatic properties of Vernonia amygdalina and Chromolaena odorata leaf extracts using Wistar rat model

Matthew

Osime

2019

Universa Medicina

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BACKGROUND The leaves of African plants are widely employed in Nigeria to control bleeding from wounds. This work is aimed at evaluating the haemostatic effects of Vernonia amygdalina (VA/bitter leaf) and Chromolaena odorata (CO/sunflower) leaves on some haemostatic parameters. METHODS A laboratory study of experimental design was conducted involving 35 Wistar rats that were randomized into seven groups. Groups 1 and 2 received leaf extracts of VA at concentrations of 150 and 250mg/kg BW, respectively; groups 3 and 4 received leaf extracts of CO at 150 and 250mg/kg BW; groups 5 and 6 received combined leaf extracts of VA and CO at 150 and 250mg/kg BW, respectively, for 30 days. The last group 7 as control group received only water. Parameters investigated were clotting time (CT), fibrinogen concentration, prothrombin time (PT), activated partial thromboplastin time test (APTT), factor VII, protein C and D – dimer. Results There was a significant reduction in CT, fibrinogen concentration and PT in the intervention groups compared to controls (p<0.01). There was no significant difference in APTT, factor VII and protein C in the intervention groups compared to the controls (p>0.05). D-dimer levels were observed to increase significantly in rats treated with 150mg/kg BW of VA and 150mg/kgBW of the combined leaf extracts (VA/CO) compared to the controls (p<0.05). Conclusion The VA and CO extracts reduced CT, PT, fibrinogen concentrations and increased D-dimer levels in rats. This study suggests the possible incorporation of the leave extracts of VA and CO in bleeding diathesis as well as in coagulation studies.

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Section: Discussionmentioning

confidence: 99%

Haemostatic properties of Vernonia amygdalina and Chromolaena odorata leaf extracts using Wistar rat model

Matthew

Osime

2019

Universa Medicina

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“…Within this group of compounds, studies on gigantecin, bullatacin, rolliniastatin, and anonin (Fig. 3) stood out because of their great bioactivity (Rojas and Uribe, 2009;Gupta et al, 2011;Alara et al, 2012;González et al, 2014;Kedari and Khan, 2014;Ansante et al, 2015;Ma et al, 2017).…”

Section: Analysis Of Trends In Scientific Publications On Botanical Biopesticidesmentioning

confidence: 99%

Botanical biopesticides: research and development trends, a focus on the Annonaceae family

Giraldo-Rivera

Álvarez

2019

Rev. Colomb. Cienc. Hortic.

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This document analyzed research and development trends related to chemical, biological and economical biopesticides based on plant extracts, with emphasis on the Annonaceae family. A systematic review of the literature between 1947 and 2018 was done with an advance search equation in a specialized data base. This paper contains the development of plant bio pesticides, their modes of action, the more prominent families according to their bioactivity and the secondary metabolites that exert control over pests that are significant in agriculture and public health. The dynamics of publications, at the national and international levels, were identified, along with the countries that lead research, patents assigned in the last 20 years, market trends and bio pesticide regulation. The reviewed research is relevant to bioprospecting plant extracts with potential insecticidal activity and to the subsequent development of biocides using botanical extracts; the Annonaceae family is promising.

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“…Vernonia amygdalina, commonly called bitter leaf because of its bitter taste is a shrub growing to a height of 3 or more meters in the African tropics and other parts of Africa, particularly, Nigeria, Cameroon, and Zimbabwe [28]. The leaves are consumed either as a vegetable (macerated leaves in soup) or aqueous extracts as tonics for the treatment of various illnesses such as anemia, nausea, diabetes, loss of appetite, dysentery, gingivitis, toothache, and gastrointestinal tract problems [29][30]. The biologically-active compounds which have been extracted and isolated from Vernonia amygdalina are: saponins and alkaloids, terpenes, steroids, coumarins, flavonoids, phenolic acids, lignans, xanthones, and anthraquinone, edotides, and sesquiterpenes [28].…”

Section: ■ Introductionmentioning

confidence: 99%

Characterization and Utilization of Sulphuric Acid and Bitter Leaf Extract Activated Carbon from Rice Husk for Zn(II) Adsorption

Osasona

Kanuhor

2021

Indones. J. Chem.

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The world is clamoring for green synthetic modes of scientific and technological operations. From this point of view, an attempt was made to prepare activated carbon from rice husk using aqueous bitter leaf extract and a mineral acid (H2SO4) separately. The surface characteristics and the adsorption properties of the activated carbons from both methods were compared. The effects of adsorption variables on the adsorption of Zn(II) by bitter leaf extract activated carbon (RHAC1) and H2SO4 activated carbon (RHAC2) were conducted through batch studies. The morphological characterization revealed RHAC1 to be fibrous, more porous and contained finer particles than the chemical-activated counterpart. The role of hydroxyl and carbonyl groups in the adsorption of Zn(II) was pivotal. The optimum pH values for the adsorption of Zn(II) by both samples was 7. The adsorption kinetics and equilibrium isotherm obeyed Elovich and Freundlich models respectively while the evaluated Langmuir qmax were 71.47 and 67.12 mg g–1 for RHAC1 and RHAC2 respectively. The thermodynamic parameters revealed that the process was endothermic and spontaneous at all evaluated temperatures. Therefore, bitter leaf aqueous extract, as an activating agent for carbon production, could serve as a better or close substitute for the less environment-friendly H2SO4.

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PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF Vernonia amygdalina: A REVIEW

Cited by 55 publications

References 42 publications

Haemostatic properties of Vernonia amygdalina and Chromolaena odorata leaf extracts using Wistar rat model

Haemostatic properties of Vernonia amygdalina and Chromolaena odorata leaf extracts using Wistar rat model

Botanical biopesticides: research and development trends, a focus on the Annonaceae family

Characterization and Utilization of Sulphuric Acid and Bitter Leaf Extract Activated Carbon from Rice Husk for Zn(II) Adsorption

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