Phytochemical and Pharmacological Review of Cryptolepis sanguinolenta (Lindl.) Schlechter

Abstract

Ethnopharmacological Relevance Cryptolepis sanguinolenta is a scrambling thin-stemmed shrub found in Africa. Traditionally in West Africa, it is employed in the treatment of malaria, diarrhea, and respiratory conditions. This review discusses the traditional importance as well as the phytochemical, ethnomedical, pharmacological, and toxicological importance of this plant. Materials and Methods Excerpta Medica Database, Google Scholar, Springer, and PubMed Central were the electronic databases used to search for and filter primary studies on Cryptolepis sanguinolenta. Results The detailed review of various studies conducted on C. sanguinolenta and some of its constituents gives an important body of proof of its potential therapeutic benefits and also of its use as a source of lead compounds with therapeutic potentials. Conclusion The review on C. sanguinolenta is important in identifying grey areas in the research on this medicinal plant and also provides comprehensive data thus far to continue research on this plant.

Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): anin silicoscreening of alkaloids and terpenoids from African medicinal plants

“…Some natural compounds and their derivatives that possess anti-inflammatory and anti-virus effects exhibit high binding affinity to 3CL pro . Likewise, alkaloids and terpenoids, from African plants, with documented antiviral, antimicrobial, antimalarial, antifungal, antileishmanial (Amoa Ongu en e et al, 2013;Ndhlala et al, 2013;Osafo et al, 2017;Setzer et al, 2001) properties may inhibit the 3CL pro of SARS-CoV-2. This could also buttress reports that some patients with COVID-19 showed improvement when treated with hydroxychloroquine, an antimalarial drug Wu et al, 2020) The 3C-like cleavage sites on the polyproteins of coronaviruses are highly conserved, and their sequence and substrate specificities are identical i.e.…”

Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi

“…Surprisingly, Andrographis paniculata, Stevia rebaudiana (44),Colloidal silver (Argentyn 23 TM ), Monolaurin (Lauricidin TM ), Dipsacus spp., and Withania somnifera, which are assumed or previously reported to have anti-borrelia activity, did not show significant activity against either stationary phase or growing B. burgdorferi in this study. Cryptolepis sanguinolenta is a plant indigenous to Africa where it has been used in traditional medicine to treat malaria, tuberculosis, hepatitis, and septicemia (45). Cryptolepis sanguinolenta has been shown in preclinical studies to have antiinflammatory (46,47) antibacterial (48)(49)(50), anti-fungal (51), anti-amoebic (52), and anti-malarial (53,54) properties.…”

Evaluation of Natural and Botanical Medicines for Activity against Growing and Non-growing Forms ofB. burgdorferi

“…Cryptolepis sanguinolenta is a plant indigenous to Africa where it has been used in traditional medicine to treat malaria, TB, hepatitis, and septicemia (51). In addition to the various uses documented in ethnomedicine, Cryptolepis sanguinolenta has been shown in preclinical studies to have anti-inflammatory (52, 53) antibacterial (54–59), Anti-fungal (55, 60), anti-amoebic (61) and anti-malarial (62–65) properties.…”