Phytochemical and Pharmacological Studies of the &lt;i&gt;Genus Tacca&lt;/i&gt;: A Review

Jiang, Jingjing; Yang, Hong-Mei; Wang, Yi-Liang; Chen, Ye‐Gao

doi:10.4314/tjpr.v13i4.23

Cited by 19 publications

(16 citation statements)

References 55 publications

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“…[150][151][152][153][154][155] These include taccalonolide A 12-propanoate (70), taccalonolide T (71) and taccalonolide S (72) from the tubers of T. leontopetaloide ( Figure 13). They have shown activities against the T. b. brucei s427 lister strain.…”

Section: Taccalonolidesmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

Preprint

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An absolute configuration of 5R seems to decrease activity of the compound IntroductionProtozoa may be considered as microscopic, essentially single-celled, eukaryotic organisms that are free-living or parasitic (obtaining their food by eating other organisms or their products) in nature. Parasitic protozoal diseases continue to be a cause of considerable morbidity and mortality globally. 1,2Parasitic protozoal diseases include malaria, 3,4 trypanosomiasis (African sleeping sickness and Chagas disease), 5-7 leishmaniasis 8 and schistosomiasis. 9,10 They threaten almost one-third of the world's population, the most numerous incidents being recorded in over 100 Tropical and developing countries and territories, Figure 1. 11,12 Malaria, for example, was reported by the WHO, to be responsible for approximately 214 million sickness cases and 438,000 deaths globally in 2017. 13 The African region recorded the most death-related cases, especially amongst infants below the age of 5 and pregnant women. Schistosomiasis, caused by parasites of the Schistosoma genus are responsible for about 200 million sickness cases and about 280,000 death-related incidents annually worldwide.9,10,14 Only one drug (praziquantel) has been proven to be effective in the treatment of human schistosomiasis, with no vaccine available or in development so far.15-21 Serious concerns about drug selectivity and resistance were raised in 2013 when over 30 million people were treated in Sub-Saharan Africa. 20 Moreover, observed resistance and reduced efficiency of praziquantel in laboratory strains have prompted the search for alternative therapeutic strategies. Trypanosomiasis, which represents several diseases caused by parasites of the genus Trypanosoma, is also of interest. 5,27,29 This disease, which is much arguably the most important disease of man and domesticated animals, accounts for over 8 million reported annual cases globally, especially in the tropical regions of Latin America and Africa. 30,31 Although the present number of cases seems negligible on a worldwide scale, great socioeconomic effects on the endemic areas by this disease are forecast if inadequate attention (both at the communal, national, and international levels) is not given. 7,29,[32][33][34] Leishmaniasis is caused by parasites of the Leishmania type, which is also transmitted by certain types of sandflies. 35,36 The diseases are reported by the WHO to be responsible for about 1 million new cases leading to approximately 30,000 deaths annually on a global scale. The major cause is linked to environmental changes A R T I C L E I N F O A B S T R A C TArticle history:English abstract: Parasitic diseases continue represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug di...

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Section: Taccalonolidesmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

Preprint

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“…Beside their proven anticancer potential, these represent a quite potent class of antitrypanosomal compounds identified from Tacca leontopetaloides (Taccaceae) [ 157 – 162 ]. These include taccalonolide A 12-propanoate ( 70 ), taccalonolide T ( 71 ) and taccalonolide S ( 72 ) from the tubers of T. leontopetaloide (Fig.…”

Section: Other Compound Classesmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Simoben

Ntie‐Kang

Akoné

et al. 2018

Nat. Prod. Bioprospect.

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Parasitic diseases continue to represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases. In the discussion, emphasis has been laid on alkaloids, terpenoids, quinones, flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma, Trypanosoma and Leishmania species. In each subparagraph, emphasis is laid on the compound subclasses with most promising in vitro and/or in vivo activities of plant extracts and isolated compounds. Suggestions for future drug development from African medicinal plants have also been provided. This review covering 167 references, including 82 compounds, provides information published within two decades (1997–2017).Graphical Abstract

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“…Taccaceae or Dioscoreales (the family of yams), particularly the genus Tacca , is mostly characterised by the presence of taccalonolides (a new class of plant-derived natural steroids with a microtubule-stabilizing activity, withanolides and their glucosides, saponins, pregnane glycosides, diarylheptanoids and their glycosides, the isolated compounds mostly showing cytotoxic, microtubule-stabilizing, NF-κB activation, PPAR transcriptional and insecticidal activities [ 16 ]. A summary of the medicinal uses and biological activities of the compounds of the Taccaceae and Tamaricaceae from Northern Africa are shown in Table 1 .…”

Section: Taccaceae and Tamaricaceaementioning

confidence: 99%

The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae

Ntie‐Kang

Njume

Malange

et al. 2016

Nat. Prod. Bioprospect.

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Traditional medicinal practices have a profound influence on the daily lives of people living in developing countries, particularly in Africa, since the populations cannot generally afford the cost of Western medicines. We have undertaken to investigate the correlation between the uses of plants in Traditional African medicine and the biological activities of the derived natural products, with the aim to validate the use of traditional medicine in Northern African communities. The literature is covered for the period 1959–2015 and part III of this review series focuses on plant families with names beginning with letters T to Z. The authors have focused on curating data from journals in natural products and phytomedicine. Within each journal home page, a query search based on country name was conducted. All articles “hits” were then verified, one at a time, that the species was harvested within the Northern African geographical regions. The current data partly constitutes the bases for the development of the Northern African natural compounds database. The review discusses 284 plant-based natural compounds from 34 species and 11 families. It was observed that the ethnobotanical uses of less than 40 % of the plant species surveyed correlated with the bioactivities of compounds identified.Graphical AbstractElectronic supplementary materialThe online version of this article (doi:10.1007/s13659-016-0091-9) contains supplementary material, which is available to authorized users.

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Phytochemical and Pharmacological Studies of the <i>Genus Tacca</i>: A Review

Abstract: Tacca is an important genus comprising of approximately 15 species of the medicinal plants (Taccaceae

Cited by 19 publications

References 55 publications

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae

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