Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae)

Fiot, Julien; Sanon, Souleymane; Azas, Nadine; Mahiou, Valérie; Jansen, Olivia; Angenot, Luc; Balansard, G.; Ollivier, Évelyne

doi:10.1016/j.jep.2005.12.030

Cited by 69 publications

(55 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Guiera senegalensis is a shrub found in the savannah region of West and Central Africa. Its leaves are commonly used in traditional medicine to treat gastrointestinal disorders, respiratory infections, rheumatism, and malaria via the preparation of febrifugal decoctions (15). Recently, it was demonstrated that alkaloids extracted from leaves of G. senegalensis had antimalarial effects.…”

mentioning

confidence: 99%

“…Unlike the beta-carboline alkaloids, guieranone A has shown activity against cancer cell lines and against normal skin fibroblasts (15). Traditionally, G. senegalensis is used in combination with Mitragyna inermis to avoid the severity of these side effects (15). The empirical discovery of these traditional treatments in areas of endemicity provides a largely untapped resource for establishing efficacious therapeutic regimens from the purified compounds.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Harmine Is a Potent Antimalarial Targeting Hsp90 and Synergizes with Chloroquine and Artemisinin

Shahinas

MacMullin

Benedict

et al. 2012

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Previous studies have shown an antimalarial effect of total alkaloids extracted from leaves of Guiera senegalensis from Mali in West Africa. We independently observed that the beta-carboline alkaloid harmine obtained from a natural product library screen inhibited Plasmodium falciparum heat shock protein 90 (PfHsp90) ATP-binding domain. In this study, we confirmed harmine-PfHsp90-specific affinity using surface plasmon resonance analysis (dissociation constant [K d ] of 40 M). In contrast, the related compound harmalol bound human Hsp90 (HsHsp90) (K d of 224 M) more tightly than PfHsp90 (K d of 7,010 M). Site-directed mutagenesis revealed that Arg98 in PfHsp90 is essential for harmine selectivity. In keeping with our model indicating that Hsp90 inhibition affords synergistic combinations with existing antimalarials, we demonstrated that harmine potentiates the effect of chloroquine and artemisinin in vitro and in the Plasmodium berghei mouse model. These findings have implications for the development of novel therapeutic combinations that are synergistic with existing antimalarials.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Harmine Is a Potent Antimalarial Targeting Hsp90 and Synergizes with Chloroquine and Artemisinin

Shahinas

MacMullin

Benedict

et al. 2012

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Gmel (Combretaceae), locally known as "sabara" or "barbarta" in hausa language of Northern Nigeria is widely distributed in western Africa (Sombie et al, 2011). Traditionally, G. senegalensis is used to treat various illnesses such as hypertension, malaria, cough, diabetes and many microbial infections (Fiot et al, 2006). The plant is also widely used by women in Katsina State, Nigeria during postpartum period for enhancing general wellbeing.…”

Section: Introductionmentioning

confidence: 99%

“…The plant is also widely used by women in Katsina State, Nigeria during postpartum period for enhancing general wellbeing. Many researchers have reported various medicinal properties of G. senegalensis including antimicrobial (Kudi et al, 1999 andFiot et al, 2006), antiulcer (Aniagu et al, 2005), antimalarial (Benoit et al, 1996, Ancolio et al, 2002 and antiviral activities (Lamien et al, 2005), to mention but few. Although some researchers reported antioxidant properties of G. senegalensis (Mariod et al, 2006;Sombie et al, 2011;Abubakr et al, 2013), to the best of our knowledge no study is reported on the optimization of protocol for the extraction of natural antioxidants from this plant.…”

Section: Introductionmentioning

confidence: 99%

Influence of Extraction Solvent on Antioxidant Properties of Guiera senegalensis J.F. Gmel (Combretaceae) Leaves

Kankara¹,

Go²

2017

Nig J Bas App Sci

View full text Add to dashboard Cite

Guiera senegalensis is widely used in West Africa for traditional medicine. In Northern Nigeria, it is used for general well-being by women during postpartum recovery period. In this study, we report the effect of extraction solvents viz acetone, chloroform, ethanol, methanol (each at 50% and 75% concentrations) and water on the phenolic antioxidant and antioxidant activity of it's leaves. Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) assays were used to determine the phenolic antioxidants. Antioxidant activity was evaluated by measuring scavenging effect on 2,2 ꞌ -diphenyl-1-picrylhydrazyl (DPPH) radical, Ferric Reducing Antioxidant Power (FRAP) and Total Antioxidant Capacity (TAC) using phosphomolybdate assay. Results shows that extraction solvents significantly (P<0.05) affect phenolic antioxidants extraction and antioxidant properties. Highest TPC value (109.20±3.99mg GAE/100g DW) was obtained in 75% ethanol. 75% acetone showed the highest TFC value (414.60±7.60mg QE/100g DW). Highest DPPH radical scavenging activity (95.82±0.63%) was observed in water solvent. 50% chloroform showed the best FRAP value (282.73±29.80mg AAE/100g DW). While 75% methanol showed the highest TAC value (102.44±3.44mg AAE/1g DW). Based on its highest TFC value as well as its insignificant differences with other solvents that showed higher values for TPC, FRAP and TAC, 75% acetone appeared to be the solvent for extracting phenolic antioxidants. Correlations study indicates highly significant positive (p< 0.001) linear correlations between phenolic antioxidants and antioxidant activities. The highest correlation (r 2 = 0.845) was observed between TFC and TAC followed by TFC and DPPH (r 2 = 0.733). Another significant correlation (r 2 = 0.659) was also observed between TFC and FRAP. Further studies aimed at isolating and identifying specific compounds responsible for antioxidant activity in G. senegalensis are recommended.

show abstract

“…Guiera senegalensis Gmel (Combretaceae) is a shrub of savannah region of West and Central Africa (Fiot et al, 2006). The leaves are bitter-tasting and have widely recognized in African medicine as a "cure-all" in herbal concoctions (Hiermann and Bucar, 1994;Jigam et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical And Antibacterial Activityof Leave Extracts Of Guiera Senegalensis Lam On Selected Species Of Gram Positive And Gram Negative Bacteria

Mamman

Isa

2013

Int. J. Environ.

View full text Add to dashboard Cite

The aim of this study was to determine the preliminary phytochemical component and antibacterial activity of the leaves extract of Guiera senegalensis lam (Combretaceae) against three clinical isolates (Staphylococcus aureus, E. coli and Klebsiella species) using standard method of analysis. The test for phytochemical component revealed the presence of alkaloid, anthraquinolones, tannin and phlobatanins. The result of antibacterial activity showed that the ethanolic extract exhibit higher zone of inhibition against all the clinical isolates, with E. coli and Klebsiella species showed zone of inhibition of 35mm followed Staphylococcus aureus 30mm. Similarly, both aqueous and methanolic extract were sensitive to all the clinical isolate except Klebsiella species which showed resistance to the methanolic extract of the leaves. The results obtained in this research imply that the leaves extract of Guiera senegalensis lam could be useful in the treatment of infections caused by Staphylococcus aureus, E. coli and Klebsiella species.

show abstract

Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae)

Cited by 69 publications

References 14 publications

Harmine Is a Potent Antimalarial Targeting Hsp90 and Synergizes with Chloroquine and Artemisinin

Harmine Is a Potent Antimalarial Targeting Hsp90 and Synergizes with Chloroquine and Artemisinin

Influence of Extraction Solvent on Antioxidant Properties of Guiera senegalensis J.F. Gmel (Combretaceae) Leaves

Phytochemical And Antibacterial Activityof Leave Extracts Of Guiera Senegalensis Lam On Selected Species Of Gram Positive And Gram Negative Bacteria

Contact Info

Product

Resources

About