Phytochemical, antimicrobial and antioxidant properties of Launaea nudicaulis and Farsetia hamiltonii

Abstract

Plant extracts could be beneficial for biocontrol of macro-organisms and micro-organisms which attack plants and it could be also beneficial for protection or treatment of some diseases in animals and human. In the current study, two plants from the arid areas in the Northern Regions in Saudi Arabia, namely, Farsetia hamiltonii and Launaea nudicaulis were screened for their phytochemical, antimicrobial and antioxidant properties. GC-MS screening of methanol extract of flowers of F. hamiltonii revealed the presence of triterpen compound (Betulins, Lanosterin), and quercterin. The methanol extract of L. nudicaulis revealed the presence of dihydro-isosteviolmethylester and flavone-4'-OH,5-OH,7-di-O-glucoside. Dihydrotorulosol and Urs-12-ene-3-one were detected in two extracts, where chloroform extract of Launaea were rich in alkaloid compounds, aspidofractinin, and tocopherol. The antioxidant activity showed that the chloroform extract of L. nudicaulis had higher antioxidant activity (IC50=1.6±0.1g/L; EC50=2.15±0.3g/L), followed by methanol extract of F. hamiltonii (IC50=3.6±0.1g/L; EC50=4.1±0.1g/L) and methanol extract of L. nudicaulis (IC50=7.1±0.2g/L;EC50=7.85±0.4g/L). The microbiological investigation revealed that methanol extract of F. hamitonii and chloroform extract of Launaea nudicaulis showed no antimicrobial activity against all tested microorganisms. While the methanol extract of L. nudica exhibited average antibacterial activity against Staphylococcus epidermidis ATCC 12228 and weak antibacterial activity against S. aureus ATCC 25923 and Escherichia coli ATCC 35218.

Chemical Profile of Launaea nudicaulis Ethanolic Extract and Its Antidiabetic Effect in Streptozotocin-Induced Rats

“…Nitrogenous compounds were detected in positive ion mode due to preferential ionization in that mode, and included aminobenzoic acid (5), dimethylamino-benzaldehyde (12), hydroxybenzylamine (9) and phenylethylamine (22).…”

“…Numerous pharmaceutical uses were documented for the different extracts of L. nudicaulis i.e., antioxidant [ 10 ], insecticidal, cytotoxic, antifungal [ 11 ] and antimicrobial activity [ 9 ]. Chemical classes reported in L. nudicaulis include essential oils [ 9 , 10 ], flavonoids, phenolics, alkaloids [ 12 ], sesqui-, di-, and triterpenoid/steroids in addition to sphingolipids [ 13 ]. We have previously reported the chemical characterization, antioxidant and phytotoxic activities of essential oils of three Launaea plants including L. nudicaulis [ 10 ].…”

The Palestinian Terrestrial Vertebrate Fauna Preserved at The Biology Exhibitions of The Universities of The Gaza Strip

“…Various extracts from aerial parts of the plant exhibited significant scavenging activity; as a result, it can protect the body from damages caused by free radical induced oxidative stress. This higher antioxidant activity was referred to the presence of natural products such as flavonoids, tannins, cardinolids alkaloids, saponins and terpenes [23][24].…”

Antioxidant, antimicrobial and antifeedant activity of phenolic compounds accumulated in Hyoscyamus muticus L.

“…The antioxidant activity was evaluated using the ferric reducing power method (FRAP) as described by Abdallah et al (2016), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method as described by El-Sharkawy et al (2017). For the FRAP method, 1 ml of each sample concentration was mixed with 2.5 ml of potassium hexacyanoferrate K3Fe(CN)6 solution and 2.5 ml of phosphate buffer (0.2 mol/L, pH 7.0) and incubated at 50°C for 30 min.…”