Phytochemical Composition and Antioxidant Activity of<i>Ficus benghalensis</i>(Moraceae) Leaf Extract

Rao, Kokati Venkata Bhaskara; Ojha, Varsha; Preeti, .; Kumar, Gaurav; Karthik, Loganathan

doi:10.1080/22311866.2014.936902

Cited by 15 publications

(4 citation statements)

References 26 publications

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“…The X-ray crystal structure of the target mammalian’s SD5ARII with a resolution of 2.8 Å was retrieved from Protein Data Bank (PDB ID: 7BW1). After docking, the binding energies (BEs) were noted, and the lowest values were chosen to view the interactions in PyMol ( Bhaskara Rao et al, 2014 ; Hassan et al, 2020 ; Bilal et al, 2021 ; Rehman et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

et al. 2021

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The screening of hair follicles, dermal papilla cells, and keratinocytes through in vitro, in vivo, and histology has previously been reported to combat alopecia. Ficus benghalensis has been used conventionally to cure skin and hair disorders, although its effect on 5α-reductase II is still unknown. Currently, we aim to analyze the phytotherapeutic impact of F. benghalensis leaf extracts (FBLEs) for promoting hair growth in rabbits along with in vitro inhibition of the steroid isozyme 5α-reductase II. The inhibition of 5α-reductase II by FBLEs was assessed by RP-HPLC, using the NADPH cofactor as the reaction initiator and Minoxin (5%) as a positive control. In silico studies were performed using AutoDock Vina to visualize the interaction between 5α-reductase II and the reported phytoconstituents present in FBLEs. Hair growth in female albino rabbits was investigated by applying an oral dose of the FBLE formulation and control drug to the skin once a day. The skin tissues were examined by histology to see hair follicles. Further, FAAS, FTIR, and antioxidants were performed to check the trace elements and secondary metabolites in the FBLEs. The results of RP-HPLC and the binding energies showed that FBLEs reduced the catalytic activity of 5α-reductase II and improved cell proliferation in rabbits. The statistical analysis (p < 0.05 or 0.01) and percentage inhibition (>70%) suggested that hydroalcoholic FBLE has more potential in increasing hair growth by elongating hair follicle’s anagen phase. FAAS, FTIR, and antioxidant experiments revealed sufficient concentrations of Zn, Cu, K, and Fe, together with the presence of polyphenols and scavenging activity in FBLE. Overall, we found that FBLEs are potent in stimulating hair follicle maturation by reducing the 5α-reductase II action, so they may serve as a principal choice in de novo drug designing to treat hair loss.

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Section: Methodsmentioning

confidence: 99%

Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

et al. 2021

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“…Apart from these, the seed ethanolic extract was reported to have the potential antioxidant capacity with plentiful amounts of secondary metabolites like polyphenols (Govindan and Francis, 2015). The abundant presence of phenolics, flavonoids, tannins, saponins, alkaloids, carbohydrates, fats, and oils reported in F. benghalensis is held responsible for its antioxidant capacity (Rao et al, 2014).…”

Section: Conventional Medicinal/ethnomedicinal Applicationsmentioning

confidence: 99%

Ficus benghalensis—A comprehensive review on pharmacological research, nanotechnological applications, and patents

Singh¹,

Dhankhar²,

Kapoor³

et al. 2023

J Appl Pharm Sci

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Plants have been an outstanding source of medicine for an incredibly long time. They are mentioned in Ayurveda, Siddha, and Unani as a fundamental source of bioactive compounds to cure and prevent several human body ailments. This review aims to recapitulate diverse medicinal and cosmetic uses, phytochemical constituents, and pharmacological actions of F. benghalensis (Banyan tree), one of India's most sacred medicinal trees. Banyan tree extracts have shown antioxidant,

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“…Dimethyl Sulfoxide, 1,2-diethyl-Cyclooctane, 5-(hydroxymethyl)-2-Furancarboxaldehyde, and (1-methylethyl)-Cyclohexane has been isolated from the fruit of F. carica [19,20]; α-cadinol, germacrene-D-4-ol, γ-cadinene, and α-muurolene isolated from leaves of F. benghalensis [21][22][23], chlorogenic, p-coumaric, ferulic and syringic acids isolated from F. benjamina roots [24][25][26]; and C-8 glucoside, isoquercitrin-6-O-4-hydroxybenzoate, and quercetin-3-O-β-rhamnoside from leaves of F. exasperata [27][28][29]. Among biological activities identified from different parts of Ficus sp were antibacterial, anticancer [30,22]; antioxidation [31][32][33]; and anti-inflammatory [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Mini-Review of Phytochemicals of Ten Ficus Species

Mudhafar¹,

Alsailawi²,

Abdulrasool³

et al. 2021

Int J Chem Res

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The present work aimed to review ten species of Ficus which is belong to the Moraceae family. In total, 36 articles were reviewed by using the online search engine PubMed, Scopus, Google Scholar, and Web of Science. Ten species of Ficus were searched for phytochemicals documentation, which resulted in 250 secondary metabolites and 400 different compounds. Alkaloids compounds such as liriodenine and lysicamine, terpenes, steroids, and flavonoids were found to have anticancer, antibacterial, antifungal, and other biological activities. Most Ficus species contain secondary metabolites compounds with different types of application. This mini-review provides insights on Ficus’s phytochemical compounds and their importance as medicinal properties.

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Phytochemical Composition and Antioxidant Activity ofFicus benghalensis(Moraceae) Leaf Extract

Cited by 15 publications

References 26 publications

Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

Ficus benghalensis—A comprehensive review on pharmacological research, nanotechnological applications, and patents

Mini-Review of Phytochemicals of Ten Ficus Species

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