Phytochemical Composition and Toxicity of Stingless Bee Propolis From Various Provinces in Indonesia

Mahani, Mahani; Syidik, Jafar; Zaida, Zaida; Sulaeman, Ahmad; Hardinsyah, Hardinsyah; Nurjanah, Nunung

doi:10.22159/ajpcr.2021.v14i5.41116

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Studies on the TAC are limited, with some stating the absence of alkaloids as in the case of Indonesian Trigona sp . propolis extracts [ 39 ]. Indian Apis mellifera propolis extract has values ranging from 6.2 to 9.8 mg/100 g which is lower compared to our results [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Differences in the biochemical content and radical scavenging activity of propolis from different parts of aMeliponula ferrugineahive

Kegode,

Mokaya,

Chogo

et al. 2023

R. Soc. open sci.

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Research on stingless bee products has increased in recent years, and of particular interest is propolis because of its biological activities such as antioxidant and antimicrobial. However, there is paucity of information regarding intra-hive variations in the biochemical composition and biofunctional properties of this propolis. In this study, we investigated the phytochemicals and radical scavenging activity (RSA) of Meliponula ferruginea propolis from 10 wooden hives ( n = 49). The samples were collected from five different locations comprising the entrance, involucrum, pillars, pots and sealant. Principal component analysis showed that there is an intra-hive variation in phytochemical content and RSA. Phenolic content constituted the highest phytochemical content in all the locations. The sealant and entrance had the highest amounts of phytochemicals compared to the involucrum, pillars and pots. Further analysis of propolis extracts by gas chromatography-mass spectrometry revealed occurrence of different compounds such as monoterpenoids, hydrocarbons, triterpenoids and alkaloids. Hydrocarbons were common in all parts while monoterpenes and triterpenes were present in the entrance. The findings of our study indicates that there is an intra-hive variation in propolis of M. ferruginea and hence this information will provide further insight into better understanding of stingless bee propolis.

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Section: Discussionmentioning

confidence: 99%

Differences in the biochemical content and radical scavenging activity of propolis from different parts of aMeliponula ferrugineahive

Kegode,

Mokaya,

Chogo

et al. 2023

R. Soc. open sci.

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“…The phytochemical study of the extract revealed the presence of some metabolites such as polyphenols, flavonoids, saponin, gallic and condensed tannins. However, the presence or not of a certain bioactive compounds in a plant material depends on the specie, the part used and the region where it is found [ 15 , 16 ]. These compounds have lipotropic activities.…”

Section: Discussionmentioning

confidence: 99%

Lipotropic activities of aqueous extract of Vernonia guineensis Benth. in Wistar rats fed high fat diet

Nnanga

Ambamba

Ella

et al. 2022

BMC Complement Med Ther

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Background Lipotropic molecules are effective therapeutic targets to counteract non-alcoholic fatty liver disease (NAFLD). Lipotropic compounds are capable of removing fat from the liver and/or manage the reduction of the synthesis or deposition of lipids in the liver. The objective of this study was to evaluate the lipotropic effects of the aqueous extract of leaves of Vernonia guineensis (AEVG) on rats fed high fat diet. Methods Twenty male rats with an average mass of 235 g were allow acclimatize for seven days, following which they were divided into four groups of five animals each. The test group was treated with high fat diet (HFD) and AEVG at 400 mg/kgBW, while positive control group received HFD and Fenofibrate at 100 mg/kgBW. The normal control group received a normal diet; and the negative control group received HFD. After 14 days of treatment, animals were sacrificed, blood and organs (liver, heart and kidneys), as well as the faeces were collected for the preparation of plasma and homogenates respectively. Some markers of lipid profil (total cholesterol, triglycerides, HDL-c, LDL-c,) and markers of toxicity (AST, ALT, γ-GT, creatinine) were evaluated. Results The results obtained showed that a HFD at the hepatic level led to the accumulation of lipids (triglycerides (TG) and total cholesterol (TC)) and had adverse effects on hepatic function by promoting cytolysis. At the plasma level, HFD induced hyperlipidemia. Administration of AEVG at 400 mg/kgBW improved the blood lipid profile and reduced the storage of TG and cholesterol in the liver. AEVG also promoted fecal cholesterol excretion and reduced atherogenic indices which include Total Cholesterol/High-Density Lipoprotein cholesterol (TC/HDL-c) and Low-Density Lipoprotein cholesterol/High-Density Lipoprotein cholesterol (LDL-c/HDL-c). The extract exhibited hepato-protective activity (anticholestasis) and improved glomerular filtration. Conclusion These findings suggest that AEVG possesses lipotropic effects confirming its probable use in the management of non-alcoholic fatty liver disease and its cardiometabolic complications. This virtue could be exploited for local pharmaceutical development.

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“…This botanical variability contributes to the differences observed in bioactive compound contents not only between the two-propolis types (Pr1 and Pr2) but also in comparison to propolis from various countries, as documented in the literature. 53…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Moroccan Propolis: Unraveling the Phytochemical Diversity, Chemical Composition, and Antioxidant Potential Across Two Seasons

2023

TJNPR

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Propolis, a natural resinous substance collected by honeybees from plant and tree buds, has been recognized for its diverse biological activities and therapeutic potential. In this research, we delve into the potential of propolis collected from the Gharb region of Morocco during the summer and autumn seasons. This study aimed to highlight its nutritional profile and phytochemical compounds, shedding light on its potential as an antioxidant and a valuable product. Through detailed chemical analysis, we discern significant variations in the composition of two types of propolis coded propolis1 and propolis2, particularly evident in the elevated ash (15.23% vs. 13.83%) and lipid (23.9% vs. 15.67%) content. While protein contents (0.66% vs. 1.29%) and crude fiber (1.7% vs. 1.6%) were relatively lower. While, the phytochemical screening revealed the presence of triterpenes, steroids, flavonoids, and tannins, displaying their potential efficacy against diverse diseases. The methanolic extracts exhibited substantial total phenolic content, measuring 2130.07 mg GAE/g DP for Propolis1 and 2124.7 mg GAE/g DP for Propolis2, highlighting robust antioxidant potential. Eventually, propolis exhibited wide-ranging bioactive compounds, reflecting a potent antioxidant effect and positioning it as a miraculous product. These findings emphasize the significance of propolis as a natural resource with diverse health-promoting properties, contributing to potential applications in the cosmetic and dietary fields.

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Phytochemical Composition and Toxicity of Stingless Bee Propolis From Various Provinces in Indonesia

Cited by 5 publications

References 24 publications

Differences in the biochemical content and radical scavenging activity of propolis from different parts of aMeliponula ferrugineahive

Differences in the biochemical content and radical scavenging activity of propolis from different parts of aMeliponula ferrugineahive

Lipotropic activities of aqueous extract of Vernonia guineensis Benth. in Wistar rats fed high fat diet

Moroccan Propolis: Unraveling the Phytochemical Diversity, Chemical Composition, and Antioxidant Potential Across Two Seasons

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