Phytochemical composition, cytotoxicity and in vitro antiplasmodial activity of fractions from Alafia barteri olive (Hook F. Icon)-Apocynaceae

Lasisi, A. A.; Olayiwola, M.A.; Balogun, S. A.; Akinloye, Oluyemi; Ojo, D. A.

doi:10.1016/j.jscs.2012.05.003

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…The brine shrimp (Artemia salina) lethality assay for possible cytotoxicity was moderate. However, the leaf was higher in cytotoxicity as compared to the root fractions (Lasisi et al, 2012).…”

Section: Alafia Barteri Oliv -Apocynaceaementioning

confidence: 85%

“…Leaf infusion and root decoctions are used in Nigeria and other African countries as a remedy for malaria (Olowokudejo et al, 2008). Phytochemical constituents of the ethanol extract of leaf and root showed the presence of total polyphenols, flavonoids, tannins, saponins, alkaloids and terpenoids (Lasisi et al, 2012). Hamid and Aiyelaagbe (2011) reported the presence of reducing sugars, glycosides, flavonoids and anthraquinones for all the extracts.…”

Section: Alafia Barteri Oliv -Apocynaceaementioning

confidence: 96%

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A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Gbadamosi¹,

Erinoso²

2016

Afr. J. Pharm. Pharmacol.

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Breast cancer is the leading malignancy in the South Western Nigeria; it is second to cancer of the cervix in the northwest. In north-central, 22.41% of new cancer was registered for breast cancer in five years and accounted for 35.41% of all cancers in women. The limitations of orthodox drugs such as cost, accessibility, effectiveness, and side effects necessitate the search for cheap, safe and effective phytomedicine in cancer management. Thus, this paper reviewed twenty plants used traditionally for the management of breast cancer; this was with a view to presenting them for future research activities and scientific validation of their potency in cancer regimen.

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Section: Alafia Barteri Oliv -Apocynaceaementioning

confidence: 85%

Section: Alafia Barteri Oliv -Apocynaceaementioning

confidence: 96%

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Gbadamosi¹,

Erinoso²

2016

Afr. J. Pharm. Pharmacol.

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“…In recent years, several chemical studies (e.g. Hamid and Aiyelaagbe, ; Sofidiya et al ., ; Lasisi et al ., ) have dealt with Alafia spp. but do not consider PAs sensu lato .…”

Section: Resultsmentioning

confidence: 99%

Pro-toxic 1,2-Dehydropyrrolizidine Alkaloid Esters, Including Unprecedented 10-Membered Macrocyclic Diesters, in the Medicinally-used Alafia cf. caudata and Amphineurion marginatum (Apocynaceae: Apocynoideae: Nerieae and Apocyneae)

et al. 2016

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The presence of pro-toxic dehydropyrrolizidine alkaloids suggests that medical preparations of these plants pose potential health risks to consumers. Dehydropyrrolizidine alkaloids are evidently more widespread in Apocynoideae than previously assumed, and it would seem rewarding to study other members of this family for the presence of pyrrolizidines, dehydropyrrolizidines and dihydropyrrolizines. Copyright © 2016 John Wiley& Sons, Ltd.

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“…It is valued for its efficacy in the traditional medicine system in Nigeria and other African countries, as an anti-inflammatory and fever remedy. The infusion of the leaves and twining stem are used for the treatment of inflammation and fever [4,5,6]. The extracts of the leaves were found to have antibacterial and antifungal activities [5].…”

Section: Introductionmentioning

confidence: 99%

“…The extracts of the leaves were found to have antibacterial and antifungal activities [5]. The aqueous leaf extract was reported to display potent anti-plasmodial activity [6]. In South-Western Nigeria (Lagos), Alafia barteri has been used for the treatment of malaria [7].…”

Section: Introductionmentioning

confidence: 99%

Proximate, Mineral Composition and Phytochemical Screening of Aqueous Leaf Extract of Alafia barteri Oliv. (Apocynaceae)

Adefisan

Ebuehi

Odesanmi

2020

IJBcRR

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Alafia barteri leaves are valued for its efficacy in the traditional medicine system in Nigeria. It has been used over the years for the treatment of various diseases some of which include malaria, sickle cell anaemia, and eye infections. This has necessitated the evaluation of its chemical composition to ensure its safety for human use. This study was undertaken to evaluate the phytochemical constituents, proximate and elemental composition of Alafia barteri leaf. The phytochemicals and proximate analyses were carried out using standard methods. The mineral elements were analyzed using atomic absorption spectrophotometry. The proximate analysis of the leaves showed it contained moisture 8.6%, crude fibre 48.29%, protein 15.84%, carbohydrate 13.13%, lipids 7.23% and ash 6.75%. The mineral analysis of the leaves revealed the presence of the following minerals: calcium (96.2 mg/100 g), manganese (74.8 mg/100 g), iron (46.2 mg/100 g), magnesium (31.05 mg/100 g), potassium (3.3 mg/ 100 g), sodium (2.9 mg/100 g). The phytochemical screening indicated the presence of flavonoids, phenols, tannins, anthraquinones, phlobatannins, cardiac glycosides and steroids. The study revealed the leaves of Alafia barteri to be a potential source of minerals and nutrients needed for human nutrition.

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Phytochemical composition, cytotoxicity and in vitro antiplasmodial activity of fractions from Alafia barteri olive (Hook F. Icon)-Apocynaceae

Cited by 10 publications

References 15 publications

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

Pro-toxic 1,2-Dehydropyrrolizidine Alkaloid Esters, Including Unprecedented 10-Membered Macrocyclic Diesters, in the Medicinally-used Alafia cf. caudata and Amphineurion marginatum (Apocynaceae: Apocynoideae: Nerieae and Apocyneae)

Proximate, Mineral Composition and Phytochemical Screening of Aqueous Leaf Extract of Alafia barteri Oliv. (Apocynaceae)

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