Phytochemical Compositions in Some Nigerian Medicinal Plants and Their Pharmacological Properties: A Review

Kutama, Rabiu Musa; Abdulkadir, Safiyya; Kwalli, Sani Ahmad; Chiroma, Gambo

doi:10.11648/j.ja.20180601.14

Cited by 12 publications

(8 citation statements)

References 36 publications

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“…Latex from 5 leaf strands of the same plant was pooled, and 1 ml was diluted with 19 ml of sterile water to make 1:20 dilution and estimated for alkaloids [18], tannins [19], anthraquinones, saponins [20], phenol [21], flavonoids, glycoside, phlobatannins [22], and terpenoids [23].…”

Section: Bioactive Compound Analysismentioning

confidence: 99%

Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

Akinduti

Obafemi

Isibor

et al. 2021

Open Access Maced J Med Sci

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Uncontrolled use of antibiotics has resulted in the emergence of resistant bacteria. It has necessitated the evaluation of antibacterial activities and phylo-diversity of Aloe vera (also called Aloe barbadensis) plants as antimicrobial agent in Nigeria. Biotyped enteric bacilli of 251 strains obtained from fecal samples of patients with various gastro-intestinal complications are profiled for antibiogram. Resistant biotypes were assayed for susceptibility to Aloe vera latex and further evaluated for time-kill kinetics and phylo-diversity. More than 30% of enteric bacilli, including Citrobacter freundii, Escherichia coli and Proteus mirabilis were resistant to cotrimoxazole, ciprofloxacin, and tetracycline respectively at MIC >16 µg/ml (p=0.004). Aloe vera latex significantly inhibited 39.5% resistant enteric biotypes with a significant average reduction of the viable count at 1xMIC and 2xMIC to less than 3.0 Log10CFU/mL after 24 hours. Flavonoids, alkaloids, terpenoids and anthraquinine in anti-enteric sap significantly correlated and regressed with antibacterial activity (p<0.05), while two of the antimicrobial Aloe vera plants showed phylogenetic relatedness with other homologous. Anti-bacteria efficacy of some Nigerian Aloe vera latex could provide alternative therapy, while its phylo-diversity and genomic profiling would offer a promising avenue for identification and development of antimicrobial agents as drug candidates for natural antibiotics.

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Section: Bioactive Compound Analysismentioning

confidence: 99%

Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

Akinduti

Obafemi

Isibor

et al. 2021

Open Access Maced J Med Sci

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“…However, the results of ethanol-water (6.53 ± 0.15 mg EAA/mL) is approximately 6 times superior with those of the acetone (1.45 ± 0.02 mg EAA/mL) and the decoction (1.12 ± 0.03 mg EAA/mL). Among the Acacia genus, nilotica species would be most studied (Guinko, 1991;Nacoulma, 1996;Tahir et al, 1999;Atif et al, 2012;Benbrahim et al, 2014;Kutama et al, 2018). To our knowledge, there wouldn't have to meet study on the antioxidant properties of A. gourmaensis.…”

Section: Total Antioxidant Capacitymentioning

confidence: 99%

Untitled

2019

IBSPR

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In this present study, in vivo antiplasmodial and antioxidant activities of Acacia gourmaensis A. RICH. (Mimosaceae) were evaluated based on its total extracts (ethanol-water, decoction, acetone), fractions (hexane fraction, ethyl acetate fraction, butanol fraction and aqueous fraction) and mineral contents. Total extract of decoction, acetone and EtOH-H2O fractions were used to evaluate chemical composition using HPLC-GC/MS-DAD methods. This plant is used in traditional medicine against liver disease, fractures, coughing fits and especially paludism. The antioxidant property was analyzed using 3 methods such as total antioxidant activity (TAC), iron reducing power (IRP) and radical scavenging activity (DPPH*). Antiplasmodial activity was performed in mice using red blood infected by Plasmodium berghei. The biological activities (antioxidants and antiplasmodial) were directed against plant phytochemical content 9 polyphenolic compounds were highlighted in the HPLC-DAD method, against 3 in HPLC-GC/MS. EtOH-H2O gave the best anti-TAC with 6.53 ± 0.15 mgEAA/mL. However, this extract (EtOH-H2O) gave the weakest activity with radical scavenging activity (23.73 ± 0.11 µg/mL). The best anti-DPPH* is obtained with acetone extract (1.93 ± 0.05 µg/mL). Concerning anti-IRP activity, hexane fraction gave the best result with 0.12 ± 0.00 µg/mL. At the antiplasmodial level, the best percentage reduction (19.9 %) is obtained with a dose of 150 mg/kg. On the phytochemistry plan, aqueous and ethyl acetate fractions given the best content with respectively 119.14 ± 8.13 mg EAG/g for total phenolic and 5.33 ± 0.17 EQ/g for total flavonoids. Mineral content quantification show that this plant is rich in calcium with 23.43 ± 1.32 mmol/L. The results due to the antiplasmodial activity could justify the traditional use of this plant.

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“…Natural compounds have been extensively explored for new drug discoveries [ 17 ]. Extracts of different parts of plants contain bioactive compounds, such as alkaloids, steroids, tannins, glycosides, volatile oils, fixed oils, resins, phenols, terpenoids, and flavonoids that fight against diseases [ 18 ]. The phenolic phytochemicals from plants play a key role as antimicrobial agents [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Assessing the Efficiency of Antimicrobial Plant Extracts from Artemisia afra and Eucalyptus globulus as Coatings for Textiles

Nortjie,

Basitere,

Moyo

et al. 2024

Plants

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This study aimed to assess the antimicrobial activities of plant extracts from Artemisia afra and Eucalyptus globulus when used as coatings for textiles. A pulsed ultrasound-assisted extraction method (PUAE) was employed to obtain methanolic and hexanoic extracts from both plants. Eucalyptus globulus methanol extraction exhibited the highest yield at 22.76% (±0.61%), while Artemisia afra demonstrated lower yields. Phytochemical screening identified various secondary metabolites in the extracts, including phenols, quinones, and steroids. Antimicrobial tests against Staphylococcus aureus and Escherichia coli revealed varying degrees of susceptibility, with Eucalyptus globulus hexanoic extracts showing the highest activity against Staphylococcus aureus at an average percentage growth of 18.74% (±0.26%). Minimum inhibitory concentration (MIC) values were determined for the extracts, but complete inhibition did not occur at concentrations below 500 μg/mL. The extracts exhibited varying effects on Staphylococcus aureus and Escherichia coli growth, with some extracts promoting bacterial growth. Coating textiles with Eucalyptus globulus methanolic extracts demonstrated antibacterial activity against Staphylococcus aureus with the highest zone of inhibition observed in cotton-coated samples (258.4 mm2). Polyester-coated samples exhibited smaller inhibition zones, with the lowest observed in Eucalyptus globulus methanolic extract coating (65.97 mm2). Scanning electron microscope (SEM) analysis revealed visible surface morphology changes in coated fabrics, depicting fine, cluster, lumpy, flaky, and fragment-like morphologies. Laundering effects on coated fabrics were investigated, showing a significant decrease in antimicrobial activity after washing. Fourier-transform infrared spectroscopy (FTIR) identified functional groups in the extracts associated with antimicrobial properties. The complexity of the bioactive compounds suggests potential antimicrobial efficacy, resting on factors such as geographical location, climate, and extraction methods. Notwithstanding the limitations, this study contributes valuable insights into the use of plant extracts as antimicrobial coatings for textiles.

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Phytochemical Compositions in Some Nigerian Medicinal Plants and Their Pharmacological Properties: A Review

Cited by 12 publications

References 36 publications

Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

Untitled

Assessing the Efficiency of Antimicrobial Plant Extracts from Artemisia afra and Eucalyptus globulus as Coatings for Textiles

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