Phytochemical Constituents and Antioxidant Potential of Crude Extracts from Lippia Javanica (Burm.f.) Spreng Leaves

Osunsanmi, Foluso Oluwagbemiga; Zharare, Godfrey Elijah; Opoku, Andy R.

doi:10.5530/pj.2019.11.128

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…Lower values of IC 50 of compound denotes better activity, and vice-versa. 30 The similarity in the IC 50 of methanol crude extract when compared with ascorbic acid, the positive control indicated that methanol crude extract possessed high antioxidant potential. Interestingly, the finding from this study also negated popular opinion that crude extracts with ABTS radical activity may not inhibit DPPH scavenging activity because of the method of preparation and solubility.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Constituents and Antioxidant Activities of Crude Extracts from Acacia Senegal Leaf Extracts

Uzunuigbe¹,

Osunsanmi²,

Masamba³

et al. 2019

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Background: Acacia senegal (Fabaceae) Wild is a leguminous tree with economic values, but its leaves are under-utilised. Objective: To investigate the phytochemical constituents and antioxidant potential of crude extracts from A. Senegal's leaves. Methods: Methanol and acetone crude extracts of leaves of A. senegal were prepared by maceration using organic solvents, methanol and acetone respectively. Qualitative and quantitative phytochemical analysis of the crude extracts were evaluated using Association of Agricultural and Chemist (AOAC) protocols. Antioxidant activities of the crude extracts were determined using 2, 2′-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) respectively. Results: The crude extracts (acetone and methanol) showed vary quality of phytochemical constituent including flavonoid, alkaloids, carbohydrate, saponins, tannin, steroids, and terpenoids. Acetone crude possessed significant (P < 0.05) higher total flavonoid and proanthocyanidin content in comparison with methanol extracts. Whereas, methanol crude extract possessed significant higher total phenol content compared with acetone crude extract. The crude extracts showed antioxidant activities as evidence in scavenging ABTS and DPPH radicals. However, acetone crude with lower IC 50 of 0.09 mg/mL possessed significant higher ABTS scavenging ability compared to methanol (0.07 mg/mL) and ascorbic acid (0.07 mg/mL). Conclusion: The crude extracts could serve as a promising natural antioxidant agent in management of oxidative stress diseases. For further studies, bioactive compounds need to be ascertained.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Constituents and Antioxidant Activities of Crude Extracts from Acacia Senegal Leaf Extracts

Uzunuigbe¹,

Osunsanmi²,

Masamba³

et al. 2019

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“… Cold, cough, shortness of breath (dyspnoea), respiratory complaints, bronchial problems, fever, asthma, chronic coughs Anti-inflammatory, antioxidant, anti-amoebic, antimicrobial, antibacterial, antifungal, anti-mycobacterial, antiviral and anti-plasmodial activities. Safe LC 50 1138 ± 1.33 μg/ml Endris et al (2016) ; Maroyi (2017b) ; Osunsanmi et al (2019) Zingiberaceae *Zingiber offinale Roscoe Cough, flu and colds Antioxidant, anticancer, anti-inflammatory, anti-apoptotic, antiviral, antiemetic, antimicrobial, immunomodulatory, anti-tumorigenic, antilipidemic, and anti-hyperlipidemic activities. Isolated essential oils from the plant was reported to initiate a relaxing property on rat's airway and tracheal contraction.…”

Section: Methodsmentioning

confidence: 99%

Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

Nyagumbo¹,

Pote²,

Shopo³

et al. 2022

Physics and Chemistry of the Earth, Parts A/B/C

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“…The leaves of Artemisia afra, Artemisia absinthiumin and Pittisporum viridflorum were respectively plucked and rinsed with clean water to remove dirt (Osunsanmi et al, 2019). Afterward they were air dried at room temperature (25°C) for 48 hours and pulverized using Laboratory grinder (Retsch,ZM 200).…”

Section: Plants Preparation and Extractionmentioning

confidence: 99%

“…Afterward they were air dried at room temperature (25°C) for 48 hours and pulverized using Laboratory grinder (Retsch,ZM 200). Pulverized sample (50 kg) of each plant was separately macerated (1: 5 w/v X 3) with different solvents (aqueous; methanol; and dichloromethane) and incubated on a platform shaker (150 rpm; 25ºC) for 72 hours (Osunsanmi et al, 2019). The solvents were refreshed every 24 h. The crude extracts were filtered through Whatman no 1 filter paper and the methanol and dichloromethane filtrates were concentrated in vacuo using Buchi (Model R-200) rotary evaporator (48 rpm; 40ºC) (Osunsanmi et al, 2019).…”

Section: Plants Preparation and Extractionmentioning

confidence: 99%

“…Hence, the search for novel antiviral agents with multitherapeutic potentials is imperative. Natural products, especially those that are used in traditional medicine, are regarded as effective, cheaper and safer remedy against various diseases (Osunsanmi et al, 2019). Coupled with their broader spectrum of biological activities, medicinal plants remain the frontline therapy to over-ride drugs resistant virus strains (Ogbole et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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In vitro antiviral, antioxidant and in vivo antipyretic activity of three South Africa medicinal plants crude extracts

Osunsanmi¹,

Yotwana²,

Mosa³

et al. 2022

BLACPMA

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This study investigated anti-viral, antioxidant activity and anti-pyretic of crude extract from Artemisia afra, Artemisia absinthium and Pittiosporum viridflorum leaves. The crude extracts were prepared by maceration using aqueous, methanol and dichloromethane respectively. Antiviral studies were evaluated with influenza virus using Fluorescence based -Neuraminidase inhibitors. Antioxidant activities determined with DPPH, Nitric oxide, hydroxyl and super oxide anion radicals’ Anti-pyretic activities were evaluated using rats with yeast induced pyrexia. Total phenol, flavonoids, and pro-anthocyanin contents of the plants samples were evaluated using standard protocols. The crude extracts exhibited neuraminidase inhibitory activity against the influenza virus at different thresholds. Artemisia absinthium aqueous extract showed the best activity against A/Sydney/5/97. Whereas Artemisia afra methanol crude extract displayed highest antioxidant potential against the tested antioxidant parameters. All the crude extracts significantly reversed yeast induced pyrexia in rats, similar to paracetamol. Thus, they could serve as natural remedy for respiratory diseases such as Influenza.

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Phytochemical Constituents and Antioxidant Potential of Crude Extracts from Lippia Javanica (Burm.f.) Spreng Leaves

Cited by 6 publications

References 17 publications

Phytochemical Constituents and Antioxidant Activities of Crude Extracts from Acacia Senegal Leaf Extracts

Phytochemical Constituents and Antioxidant Activities of Crude Extracts from Acacia Senegal Leaf Extracts

Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

In vitro antiviral, antioxidant and in vivo antipyretic activity of three South Africa medicinal plants crude extracts

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