Phytochemical Constituents and Biological Activities of Plants from the Genus<i>Cissampelos</i>

He, Jun-Hua; Li, Fangyi; Yan, Xiaohui; Qian, Cheng; Xue, Rongtao; Yu, Heshui; Li, Zheng; Wang, Chunhua

doi:10.1002/cbdv.202100358

Cited by 3 publications

(2 citation statements)

References 82 publications

(176 reference statements)

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“…N-Feruloyltyramine ( 16) is a phenolic amide alkaloid previously detected in Lycium barbarum fruits and A. alopecuroides [10,35]. Isochondrodendrine ( 24) is bis benzyli-soquinolinic alkaloids previously reported in the Cissampelos pareira plant [46,51]. Finally, Conessine (26), a pentacyclic steroidal alkaloid, has been isolated from Holarrhena floribunda G. Don.…”

Section: Metabolomic Profiling Of the Methanolic Extract Of A Alopecu...mentioning

confidence: 97%

Chemical Profiling and Molecular Docking Study of Agathophora alopecuroides

Amin

Abdel-Bakky

Mohammed

et al. 2022

Life

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Natural products continue to provide inspiring chemical moieties that represent a key stone in the drug discovery process. As per our previous research, the halophyte Agathophora alopecuroides was noted as a potential antidiabetic plant. However, the chemical profiling and highlighting the metabolite(s) responsible for the observed antidiabetic activity still need to be investigated. Accordingly, the present study presents the chemical profiling of this species using the LC-HRMS/MS technique followed by a study of the ligand–protein interaction using the molecular docking method. LC-HRMS/MS results detected twenty-seven compounds in A. alopecuroides extract (AAE) belonging to variable chemical classes. Among the detected compounds, alkaloids, flavonoids, lignans, and iridoids were the most prevailing. In order to highlight the bioactive compounds in AAE, the molecular docking technique was adopted. Results suggested that the two alkaloids (Eburnamonine and Isochondrodendrine) as well as the four flavonoids (Narirutin, Pelargonidin 3-O-rutinoside, Sophora isoflavanone A, and Dracorubin) were responsible for the observed antidiabetic activity. It is worth mentioning that this is the first report for the metabolomic profiling of A. alopecuroides as well as the antidiabetic potential of Isochondrodendrine, Sophora isoflavanone A, and Dracorubin that could be a promising target for an antidiabetic drug.

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Section: Metabolomic Profiling Of the Methanolic Extract Of A Alopecu...mentioning

confidence: 97%

Chemical Profiling and Molecular Docking Study of Agathophora alopecuroides

Amin

Abdel-Bakky

Mohammed

et al. 2022

Life

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“…Preliminary phytochemical analysis of golden berry calyx and fruit extracts (Table 1) revealed the presence of flavonoids, steroids, phenols, tannins, phlobatannins, and saponins. These secondary metabolites play an important role in the biological actions of therapeutic herbs, such as antioxidant, antibacterial, and anti-inflammatory activities, among others (He et al 2021). Flavonoids are called "nature's biological response modifiers" owing to their intrinsic capacity to adjust the body's response to allergens and viruses; moreover, they have anti-inflammatory, antiallergic, antimicrobial, and anticancer properties (Mansuri et al 2014).…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Phytochemical screening, antioxidant and antibacterial activities of golden berry (Physalis Peruviana L.) extract and its effect on the storage stability of tomato paste

Anwar¹,

eed²,

El-Chaghaby³

et al. 2022

Arab Universities Journal of Agricultural Sciences

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This study focused on the phytochemical, antioxidant, and antimicrobial activities of the ethanol extracts of golden berry calyx and fruits. The phytochemical analysis of calyx and fruit extracts revealed high total phenols and flavonoids. High antioxidant capacity was recorded for fruit extracts. Fruit extracts also gave the highest antibacterial activity against Pseudomonas fluorescens, Escherichia coli, and Salmonella typhimurium. Furthermore, tomato paste was prepared using sodium benzoate and golden berry extract as food preservatives. The incorporation of golden berry extract and chemical preservatives maintained the paste quality indicators over the control samples. A rapid decline in total antioxidant capacity was also observed in control samples (21.6%) as compared with the treated samples (15.21% and 15.41% for sodium benzoate and golden berry extract, respectively) after 30 days of storage. This study demonstrated that dried fruit extract with high phytochemical and antimicrobial properties could be used as a natural food preservative.

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Potential MAO‐B Inhibitors from Cissampelos Capensis L.f.: ADMET, Molecular Docking, Dynamics, and DFT Insights

Al‐Thiabat,

Agrawal,

Kumar Sahu

et al. 2024

Chemistry & Biodiversity

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This study explores the therapeutic potential of three proaporphine alkaloids—cissamaline, cissamanine, and cissamdine, which were recently isolated from Cissampelos capensis L.f., against Parkinson's disease (PD). Using computational techniques, we investigated their efficacy as inhibitors of a key protein in PD. ADMET analysis demonstrated that these alkaloids conform to the Lipinski, Pfizer, Golden Triangle, and GSK rules, indicating favorable safety, oral bioavailability, and a high probability of passing the human intestinal and blood‐brain barriers. They were neither substrates nor inhibitors of any CYP enzymes tested, indicating minimal metabolic interference and an enhanced safety profile. Molecular docking studies revealed strong binding energies with MAO‐B, PD's target. MD simulations supported these findings, showing stable interactions with MAO‐B, while Density Functional Theory (DFT) calculations highlighted the electrophilic nature of cissamanine, enhancing its potential as an effective inhibitor. These results advocate further in vitro and in vivo studies to evaluate their potential as PD therapeutics.

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Phytochemical Constituents and Biological Activities of Plants from the GenusCissampelos

Cited by 3 publications

References 82 publications

Chemical Profiling and Molecular Docking Study of Agathophora alopecuroides

Chemical Profiling and Molecular Docking Study of Agathophora alopecuroides

Phytochemical screening, antioxidant and antibacterial activities of golden berry (Physalis Peruviana L.) extract and its effect on the storage stability of tomato paste

Potential MAO‐B Inhibitors from Cissampelos Capensis L.f.: ADMET, Molecular Docking, Dynamics, and DFT Insights

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