Phytochemical constituents and ethnobotany of the leaf extract of bitter leaf (&lt;i&gt;Vernonia amygdalina&lt;/i&gt;) Del

Ugwoke, Cec; Nzekwe, U; Ameh, G. I.

doi:10.4314/jophas.v7i3.63409

Cited by 6 publications

(7 citation statements)

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“…However, the result is in conformity with an earlier work by Ekam et al 11 in which the ethanolic extract of Vernonia amygdalina contained all the secondary metabolites that were tested and were present in this study. The presence of alkaloid, saponin, and tannin in relative higher quantities agrees with the report of Ugwoke et al 12 in which similar observation was made. The response elicited by the ethanol extract of Vernonia amygdalina on the rabbit jejunum which mimics that of acetylcholine may be attributable to one or more of these secondary metabolites detected.…”

Section: Resultssupporting

confidence: 82%

Phytochemical Screening and Purgative Activity of Ethanolic Extracts of Vernonia Amygdalina Del. Leaf

Wazis¹,

Sy²,

Zakama³

et al. 2013

Int. J. Res. Ayur. Pharm.

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Vernonia amygdalina has diverse ethno-medical uses including constipation. The aim of this study was to determine the phytochemical component and purgative effect of ethanolic extract of Vernonia amygdalina leaf on rabbit jejunum. Leaves of Vernonia amygdalina were collected, dried, ground and extracted using 95% ethanol. Isolated tissue of rabbit jejunum was challenged with acetylcholine as standard and different strength of the extract at dose ranges of 10 mg to 160 mg in a 50 ml capacity organ bath. The preliminary phytochemical analysis revealed the presence of alkaloids, tannins, phlabotannins, saponins, and anthraquinones. Alkaloids, tannins, and saponins appeared in high quantities, while steroids and flavonoids were absent. The extract at concentrations of 0.2, 0.4, 0.8, 1.6 and 3.2mg/ml produce contractile responses of 3.0, 7.0, 10.2, 15.3 and 15.0 mm respectively which were dose depended. Atropine was able to block the contraction exerted by the extract. These suggest that the extract may be acting on the muscarinic receptors (M3) which are present on the intestine. This study amply justifies the ethno medical claim that the leaves are used as purgatives.

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Section: Resultssupporting

confidence: 82%

Phytochemical Screening and Purgative Activity of Ethanolic Extracts of Vernonia Amygdalina Del. Leaf

Wazis¹,

Sy²,

Zakama³

et al. 2013

Int. J. Res. Ayur. Pharm.

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“…Results of the study revealed that its phytochemical constituents include alkaloid, tannins, saponins, cardiac glycosides, terpenoids, and reducing sugars. The phytochemical contents (Table 4) of the present study extract show considerable close similarities with those of past studies [14,15]. The significant decreases in the levels of glucose may not be unassociated with phytochemical contents of the extract.…”

Section: Discussionsupporting

confidence: 86%

Investigation of Hypoglycemic and Hypolipidemic Effects of Methanolic Extracts of Bitter Leaf [Vernonia amygdalina Delile] in Male Rats

Bawa

Iyanda

2020

AJARR

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Different agents used for treatment of diabetes mellitus are associated with serious adverse effects. This necessitates the scientific quest for substitutes that are comparatively less noxious- usually medicinal plants (e.g. Vernonia amygdalina Delile). Diabetes was induced in rats in groups A-D using alloxan. Group E served as control. Once daily for 28 days, diabetic rats in groups B and C were treated with 50 & 100 mg/kg BW of methanolic extracts of Vernonia amygdalina respectively while group D rats were administered with metformin hydrochloride (250 mg/Kg BW). Rats in group A served as untreated diabetic group. Fasted blood samples were collected for estimation of fasting blood glucose (FBG); total cholesterol (TC), triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C) using standard biochemical methods. Statistical analysis was carried out using Student’s t test, P<0.05 was considered significant. After treatment, there were significant decreases in levels of FBG, TC, TG, LDL-C but increase level of HDL-C of B, C, & D when compared with group A. results of the study suggest that methanolic extract of V. amygdalina possesses antidiabetic properties and anti-hypolipidemic effects; this may explain why this plant is traditionally used for the management of diabetes mellitus and its complications.

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“…V amygdalina has been known to contain carbohydrates, saponins, alkaloids, tannins, proteins and steroids, flavonoids and glycosides [14] . The presence of phytochemicals in plant parts have been known to confer antioxidant and other properties on them as stated by heborn [15] , hence their inclusion in folk medicine.…”

Section: Resultsmentioning

confidence: 99%

An Evaluation of the Antioxidant and Blood Lead Lowering Effect of Vernonia Amygdalina Aqueous Extract on Lead Acetate Induced Oxidative Stress in Wistar Rats

Olufunsho¹,

Ayodele²

2017

Am. J. Biomed. Sci.

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The research was set to assess the antioxidant effect of Vernonia amygdalina aqueous extract on lead acetate poisoned Wistar rats. Blood lead determination and assessment of antioxidant status was carried out on five groups of rats, each group consisting of eight rats. Group I were unchallenged and unsupplemented while groups II-V were poisoned with a 150ppm lead acetate in water for 14 days. Thereafter, group II remained unsupplemented with V.Amygdalina extract, while groups III, IV and V were supplemented with 25, 50 and 75mg/kg body weight of extract for 10days. A statistically significant difference was observed when the SOD and CAT activities in groups II and III were compared to that of the control group. Similarly, significant variations were observed when the serum TBARS and blood lead levels in groups II, III and IV were compared with that of control. These values reveal a fairly proportional increase in antioxidant but reduced blood lead levels in response to increasing dosage of extract. Thus, V. amygdalina aqueous extract was able to restore the antioxidant parameters and blood lead levels back to normal. It appears to possess a dose dependent antioxidant and toxic lead excreting property. These activities may be due to the presence of phytochemical antioxidant and lead removing factor(s)/principle(s) which, if properly harnessed, can be used in the treatment of oxidant challenges and lead contamination.

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Phytochemical constituents and ethnobotany of the leaf extract of bitter leaf (<i>Vernonia amygdalina</i>) Del

Cited by 6 publications

References 0 publications

Phytochemical Screening and Purgative Activity of Ethanolic Extracts of Vernonia Amygdalina Del. Leaf

Phytochemical Screening and Purgative Activity of Ethanolic Extracts of Vernonia Amygdalina Del. Leaf

Investigation of Hypoglycemic and Hypolipidemic Effects of Methanolic Extracts of Bitter Leaf [Vernonia amygdalina Delile] in Male Rats

An Evaluation of the Antioxidant and Blood Lead Lowering Effect of Vernonia Amygdalina Aqueous Extract on Lead Acetate Induced Oxidative Stress in Wistar Rats

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