Phytochemical constituents, antidiabetic and ameliorative effects of &lt;i&gt;Polyalthia longifiola&lt;/i&gt; leaf extract in alloxan-induced diabetic rats

Anigboro, AA; Avwioroko, Oghenetega J.; Ohwokevwo, Oghenenyore Andy; Nzor, J.N.

doi:10.4314/jasem.v22i6.25

Cited by 12 publications

(12 citation statements)

References 14 publications

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“…Determination of liver enzymes and other biochemical indices were done using Prietest Easylab Biochemistry Analyzer [14]. Kidney function indices were analyzed from the sample.…”

Section: Determination Of Liver and Kidney Indicesmentioning

confidence: 99%

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Effect of Ethanol Leaf Extract of Spilanthes filicaulis on Liver Indices and Selected Biochemicals on Carbon Tetrachloride Induced Hepatic Damage in Wistar Rats

Oa¹,

Cu²

2019

Med Aromat Plants

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This study investigated the effect of ethanol leaf extract of Spilanthes filicaulis on liver indices and selected biochemicals on carbon tetrachloride induced hepatic damage in wistar rats. A total of thirty (30) rats comprising of five (5) rats per group (90-130 g), were used for the study. Groups 1-3, served as normal, negative (CCl 4 induced 1 mL/kg, 1:1 i.p.) and positive (CCl 4 induced and administered with silymarin 50 mg/kg) controls respectively. Groups 4-6 were the extract treated groups administered with 250 mg/Kg bw, 500 mg/Kg bw and 750 mg/Kg bw respectively for 14 days. The results of the liver marker enzymes showed a significant decrease (p<0.05) in Alanine Transaminase (ALT), Alkaline Phophatase (ALP) and γ-Glutamyl Transferase (GGT) levels in the positive control and extract treated groups, while aspartate transaminase (AST) levels recorded a significant decrease (p<0.05) in groups administered with 250 mg/kg (10.10 ± 0.17 U/L) and 750 mg/Kg bw (11.35 ± 2.01 U/L) when compared with the negative control group. Liver indices, showed no significant difference (p>0.05) in all treated groups when compared to the negative control group. Catalase (CAT) and Superoxide Dismutase (SOD) levels were significantly increased (p<0.05), while Nitric Oxide (NO) and Lipid Peroxidation (LPO) levels significantly decreased (p<0.05) in all groups administered with the extract when compared with the negative control group. Gluthahione levels, lipid profile, renal indices, serum electrolyte and hematological indices showed no significant difference (p>0.05) in all treated groups when compared to the negative control. The study showed that the ethanol leaf extract of Spilanthes filicaulis has potential of restoring hepatic liver damage.

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“…Determination of liver enzymes and other biochemical indices were done using Prietest Easylab Biochemistry Analyzer [14]. Kidney function indices were analyzed from the sample.…”

Section: Determination Of Liver and Kidney Indicesmentioning

confidence: 99%

“…Determination of serum sodium and potassium concentration was done using reagent kit [14]. Serum bicarbonate concentration was determined titrimetrically while mercuric nitrate method was used to determinethe concentration of chloride as modified by Teco diagnostics1268N Lakeview Avenue Anahein; CA 92807, USA.…”

Section: Determination Of Serum Electrolytesmentioning

confidence: 99%

Effect of Ethanol Leaf Extract of Spilanthes filicaulis on Liver Indices and Selected Biochemicals on Carbon Tetrachloride Induced Hepatic Damage in Wistar Rats

Oa¹,

Cu²

2019

Med Aromat Plants

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“…Malarial infection is usually associated with production of huge quantities of reactive oxygen species (ROS) by both the host and parasite, therefore inducing oxidative stress in the host system. If left untreated, prolonged infection can therefore result in further systemic complications and even death (Adebayo et al, 2017;Anigboro et al, 2018a).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents, Antimalarial Efficacy, and Protective Effect of Eucalyptus camaldulensis Aqueous Leaf Extract in Plasmodium berghei-Infected Mice

Anigboro

Avwioroko

Cholu

2020

pnf

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This study examined the bioactive components of Eucalyptus camaldulensis aqueous leaf extracts and their protective effects on liver and renal function in a Plasmodium berghei-induced albino mouse model of malarial infection. The results showed that E. camaldulensis extracts are rich in phytochemicals, including flavonoids, phenols, saponin, terpenes, and tannin. Four days after infection with malaria, elevated parasitemia levels in untreated control mice dropped by 4.57%. Administration of E. camaldulensis extracts at doses of 100, 200, and 300 mg/kg significantly decreased parasitemia levels by 17.39, 61.88, and 60.53%, respectively (all P<0.05), relative to untreated control mice; however, standard antimalarial drugs were more efficacious and reduced parasitemia by 86.73%. Treatment with both E. camaldulensis extracts (100∼300 mg/kg) and standard antimalarial drugs significantly decreased malarial-induced physiological imbalances in liver and renal biomarkers, and serum electrolytes in malaria-infected mice compared with controls (P<0.05). The therapeutic effect of E. camaldulensis was greatest at a dose of 200 and 300 mg/kg. These findings indicate that E. camaldulensis aqueous leaf extracts could protect against malarial-induced aberrations in liver and renal function whilst exhibiting anti-malarial effects, and could explain its use as an antimalarial remedy in traditional medicine.

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“…Determination of liver enzymes and other biochemical indices were done using Prietest Easylab Biochemistry Analyzer [17].…”

Section: Determination Of Liver Function Indicesmentioning

confidence: 99%

Potential of Centella asiatica leaf extract in the management of paracetamol-induced jaundice in albino rats

Uchechi¹,

Uchenna²,

Precious³

et al. 2020

World J. Adv. Res. Rev.

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Jaundice is a condition associated with the imbalance between bilirubin production and excretion when the liver is diseased. This study investigated the Potential of Centella asiatica leaf extract in the management of paracetamolinduced jaundice in albino rats. The rats were randomly distributed into six groups of five each. Group 1 (normal control-fed with rat feed and water), group 2 (paracetamol 2 g/kg body weight), group 3 (paracetamol 2g/kg bw + silymarin 100 mg/kg bw) and groups 4 -6 (2g/kg bw each + 200, 400 and 600 mg/kg bw of CaL-extract respectively). The Paracetamol was first administered to the rats for 5 days to establish jaundice followed by administration of silymarin and CaL-extract for 10 days before sacrifice. The group 2 (negative control) rats had significant increase (p<0.05) in glucose level (7.50±0.10 mmol/L) and haematological parameters like haemoglobin (8.65±0.15g/dL), packed cell volume (26.15±0.95%), red blood cell (3.75±0.05x10 12 /L) and platelet (248.00±1.00 x10 9 /L) as well as elevated levels of serum lipids (LDL, TG,TC VLDL-cholesterol) when compared with group 3 and the CaL-treated groups. Results of the liver function maker enzymes (AST, ALT and ALP) activity, serum bilirubin and proteins as well as renal function indices (creatinine, urea, chloride and bicarbonate) in group 2 were significantly increased (p<0.05); while endogenous antioxidant study, revealed low levels of catalase (1.24±0.02µmol/ml), superoxide dismutase (0.17±0.02unit/ml) and reduced glutathione (0.84±0.18mg/ml) when compared to the treated groups. Administration of the CaL-extract and silymarin ameliorated the paracetamol-induced jaundice in albino rats.

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Phytochemical constituents, antidiabetic and ameliorative effects of <i>Polyalthia longifiola</i> leaf extract in alloxan-induced diabetic rats

Cited by 12 publications

References 14 publications

Effect of Ethanol Leaf Extract of Spilanthes filicaulis on Liver Indices and Selected Biochemicals on Carbon Tetrachloride Induced Hepatic Damage in Wistar Rats

Effect of Ethanol Leaf Extract of Spilanthes filicaulis on Liver Indices and Selected Biochemicals on Carbon Tetrachloride Induced Hepatic Damage in Wistar Rats

Phytochemical Constituents, Antimalarial Efficacy, and Protective Effect of Eucalyptus camaldulensis Aqueous Leaf Extract in Plasmodium berghei-Infected Mice

Potential of Centella asiatica leaf extract in the management of paracetamol-induced jaundice in albino rats

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