Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: A review

Kumar, Anil; Shashni, Sarla; Kumar, Pawan; Pant, Deepak Raj; Singh, Ashok K.; Verma, Raj

doi:10.1016/j.jep.2021.113896

Cited by 60 publications

(30 citation statements)

References 86 publications

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“…Arnebiae Radix is a traditional Persian, Unani, Ayurvedic, and Chinese medicine with pleiotropic properties that has been used for several 100 years ( Zhu, 1982 ; Kumar et al, 2021 ). Arnebiae Radix is an ingredient in 122 Chinese patent medicines and 195 Chinese medicine prescriptions.…”

Section: Introductionmentioning

confidence: 99%

“…Arnebiae Radix is an ingredient in 122 Chinese patent medicines and 195 Chinese medicine prescriptions. Shikonin, shikonofurans, and red naphthoquinones are the main effective chemical constituents, and they have been widely used for the treatment of infections, inflammation, and bleeding for their anti-inflammatory, anti-fungal, and anti-angiogenic activities ( Gupta et al, 2014 ; Feng et al, 2020 ; Kumar et al, 2021 ). Shikonin and its derivatives exhibit anti-cancer and anti-tumorigenic activities and have the potential to be used for the development of anti-tumor drugs ( Feng et al, 2020 ; Liao et al, 2020 ; Kumar et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Phylogenomics and Genetic Diversity of Arnebiae Radix and Its Allies (Arnebia, Boraginaceae) in China

Sun

Wang

et al. 2022

Front. Plant Sci.

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Arnebiae Radix is a traditional medicine with pleiotropic properties that has been used for several 100 years. There are five species of Arnebia in China, and the two species Arnebia euchroma and Arnebia guttata are the source plants of Arnebiae Radix according to the Chinese Pharmacopoeia. Molecular markers that permit species identification and facilitate studies of the genetic diversity and divergence of the wild populations of these two source plants have not yet been developed. Here, we sequenced the chloroplast genomes of 56 samples of five Arnebia species using genome skimming methods. The Arnebia chloroplast genomes exhibited quadripartite structures with lengths from 149,539 and 152,040 bp. Three variable markers (rps16-trnQ, ndhF-rpl32, and ycf1b) were identified, and these markers exhibited more variable sites than universal chloroplast markers. The phylogenetic relationships among the five Arnebia species were completely resolved using the whole chloroplast genome sequences. Arnebia arose during the Oligocene and diversified in the middle Miocene; this coincided with two geological events during the late Oligocene and early Miocene: warming and the progressive uplift of Tianshan and the Himalayas. Our analyses revealed that A. euchroma and A. guttata have high levels of genetic diversity and comprise two and three subclades, respectively. The two clades of A. euchroma exhibited significant genetic differences and diverged at 10.18 Ma in the middle Miocene. Three clades of A. guttata diverged in the Pleistocene. The results provided new insight into evolutionary history of Arnebia species and promoted the conservation and exploitation of A. euchroma and A. guttata.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phylogenomics and Genetic Diversity of Arnebiae Radix and Its Allies (Arnebia, Boraginaceae) in China

Sun

Wang

et al. 2022

Front. Plant Sci.

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“…The anti-inflammatory properties of Arnebia euchroma can be attributed to the large amounts of phenolic compounds, shikonin, alkanin, flavones, and flavonoids in the root of the Arnebia euchroma . [ 26 ] Flavonoids prevent the release of histamine and the production of prostaglandins, which cause tenderness, pain, and swelling, and treat redness and pain. [ 25 ] Pirbalouti et al .,[ 27 ] and Mohsenikia et al .,[ 28 ] showed that an Arnebia euchroma extract has beneficial effects in accelerating the healing process of skin wounds in rats.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Effectiveness of Arnebia euchroma with ClotrimazoleVaginal Cream for the Treatment of Vulvovaginal Candidiasis

Mohammadi

Pajohideh

Iravani

et al. 2022

Iranian Journal of Nursing and Midwifery Research

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Background: Vulvovaginal candidiasis is the second most common cause of vulvovaginal infections. Due to the increasing resistance to synthetic antifungal drugs, the use of drugs with a natural origin is a priority. The aim of the present study was to compare the effectiveness of Arnebia euchroma with vaginal cream clotrimazole 1% United States Pharmacopeia (USP) for the treatment of vulvovaginal candidiasis. Materials and Methods: This triple-blind trial study was performed on 112 women with diagnosed Candida vaginitis clinically and by a laboratory test, patients were randomly divided into two groups receiving Arnebia euchroma and vaginal clotrimazole (56 people per group) in clinics and medical centers Ahvaz (Iran) from April 2018 to April 2019. Clinical and laboratory symptoms were recorded at the beginning of the study and 1 week after the end of treatment by a researcher-made questionnaire. Data analysis were performed using SPSS software v-23. p < 0.05 was considered significant. Results: After the intervention, vaginal culture was negative in terms of Candida in 17 (36.17%) patients of the Amoeba euchroma group and 37 (69.81%) patients of the clotrimazole group. The Chi-square showed that there was a significant difference between the culture results in both groups (χ 2 = 10.10, df = 1, p = 0.001). No differences were observed between the two groups in terms of vaginal symptoms based on adjustment for age and using a logistic regression model. Conclusions: A vaginal cream containing Arnebia euchroma could reduce the complaints of vulvovaginal candidiasis. But, future studies with larger sample sizes and different dosages are recommended.

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“…[3] arnebiabinone (75) [12] shikometabolin A (76) [10] shikometabolin E (77) [10] shikometabolin F (78) [10] 6-(11'-deoxyalkannin)-alkannin/shikonin β-hydroxyisovalerylate (79) [3] [13] 最早报道了紫草愈伤细胞的诱导及其培养条件，Yazaki 等 [14] 开发出使用农杆菌ATCC15834侵染紫草植株获得毛状根的方法。离体繁殖材料能否成功生产紫草素取决于为紫草素量身定制的培养基的开发，Fujita等 [15] 成功开发出可使紫草愈伤细胞和毛状根生产紫草素的M9培养基，与紫草愈伤细胞和毛状根的生长培养基(如LS、MS等培养基)相比，M9培养基含有较低浓度的NH 4+ ，而Cu 2+ 的浓度高达10倍以上，由此建立了先使用改良LS培养基在光照下进行愈伤细胞或毛状根的增殖培养，再转接到M9培养基中黑暗培养以诱导紫草素产生的两步培养法。之后，朱汝幸等 [16] 也使用两步法成功诱导了滇紫草的愈伤细胞并培养产生了高于原植株产率的紫草素。Haghbeen等 [17] 利用添加2,4-D 和激动素的LS培养基对新疆紫草种子发芽后的根外植体进行诱导，获得了大量可产紫草素的新疆紫草愈伤细胞。在此基础上，Fu等 [18] 对车前叶蓝蓟毛状根进行了诱导培养和培养体系的优化，发现该毛状根在1/2B5培养基中的培养生物量是M9培养基的5倍，且同样能产生丰富的紫草素，其中乙酰紫草宁的产量更是高…”

Section: -Methoxylithospermidin B (58)unclassified

Shikonins as natural products from traditional Chinese medicinal plants: their biosynthesis, genetic regulation, structuralmodifications, and pharmaceutical functions

Wang¹,

Yang²,

Han³

et al. 2022

Sci. Sin.-Vitae

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Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: A review

Cited by 60 publications

References 86 publications

Phylogenomics and Genetic Diversity of Arnebiae Radix and Its Allies (Arnebia, Boraginaceae) in China

Phylogenomics and Genetic Diversity of Arnebiae Radix and Its Allies (Arnebia, Boraginaceae) in China

Comparing the Effectiveness of Arnebia euchroma with ClotrimazoleVaginal Cream for the Treatment of Vulvovaginal Candidiasis

Shikonins as natural products from traditional Chinese medicinal plants: their biosynthesis, genetic regulation, structuralmodifications, and pharmaceutical functions

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