Phytochemical constituents from <i>Elsholtzia ciliata</i> (Thunb.) Hyl. and their nitric oxide production inhibitory activities

Dung, Dương Thị; Hoàng, Nguyễn Huy; Yến, Dương Thị Hải; Yến, Phạm Hải; Thu, Vu Kim; Dũng, Nguyễn Việt; Bang, Ngo Anh; Trang, Đỗ Thị; Cúc, Nguyễn Thị; Thanh, Huong Phan Thi; Tài, Bùi Hữu; Nhiệm, Nguyễn Xuân; Kiệm, Phan Văn

doi:10.1080/14786419.2022.2147170

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…1,2 Previous papers reported that phenolics are the main chemical constituents of E. blanda and some of these exhibited significantly NO inhibition effects. [3][4][5][6][7] This article reports 10 phenolics (1-10) isolated from E. blanda (1 was a previously undescribed compound), and their effects on NO production in lipopolysaccharide (LPS)-activated RAW264.7 cells.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Constituents of Elsholtzia blanda Benth

Dung

Yến

Trang

et al. 2023

Natural Product Communications

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Objectives: Elsholtzia blanda Benth. is a Vietnamese medicinal plant, used to treat inflammation, cough, and flu. Therefore, this current study focused on the isolation of the active ingredients from this plant and their NO production inhibitory activity. Methods: E. blanda aerial parts were dried, minced, and ultrasonically extracted with methanol and further separated by various chromatographic methods. The chemical structures of isolates were revealed by nuclear magnetic resonance, high resolution lectrospray ionization mass spectrometry, and circular dichroism spectra. The nitric oxide inhibition effects were evaluated in lipopolysaccharide-activated RAW264.7 cells. Results: Ten phenolic components [1 new (1) and 9 known (2-10)] were isolated and their chemical structures determined. Compound 5 (innovanoside, IC50 = 19.23 ± 1.43 µM) and 6 (maltol- O- β-D-glucopyranoside, IC50 = 21.73 ± 1.27 µM) showed the highest activity, and 2-4 showed moderate inhibition (IC50 = 47.36 ∼ 57.29 µM). The other compounds were inactive with IC50 values >100 µM. Conclusions: One previously undescribed and 9 known phenolic components isolated from E. blanda have been screened for their nitric oxide inhibitory activity. Compounds 2-6 showed moderate to significant inhibition with IC50 values of 19.23∼57.29 µM.

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Section: Introductionmentioning

confidence: 99%

Phenolic Constituents of Elsholtzia blanda Benth

Dung

Yến

Trang

et al. 2023

Natural Product Communications

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Stereochemical assignment of four monoterpene glucoside derivatives from Turpinia montana Kurz by NMR study combined with CD spectroscopy

Huong,

Anh,

Hang

et al. 2024

Magnetic Reson in Chemistry

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Turpinia genus (Staphyleaceae) consists of 10 species, including T. pentandra (Schltr.) B. L. Linden, T. brachypetala (Schltr.) B. L. Linden, T. montana Kurz, T. occidentalis (Sw.) G. Don, T. picardae Urb., T. paucijuga Lundell, T. malabarica Gamble, T. doanii Than Dinh Dai & Yakovlev, T. hatuyenensis Than Dinh Dai & Yakovlev, and T. simplicifolia Merr. T. montana Kurz has been used as a medicinal plant in Vietnam to treat osteoclastogenesis. 1 However, the phytochemical investigation of T. montana has not been investigated yet. This paper reported the isolation and structural elucidation of four new monoterpene glucosides from the leaves of T. montana (Figure 1).

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Phytochemical constituents from Elsholtzia ciliata (Thunb.) Hyl. and their nitric oxide production inhibitory activities

Cited by 2 publications

References 23 publications

Phenolic Constituents of Elsholtzia blanda Benth

Phenolic Constituents of Elsholtzia blanda Benth

Stereochemical assignment of four monoterpene glucoside derivatives from Turpinia montana Kurz by NMR study combined with CD spectroscopy

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