Phytochemical constituents of Comastoma pedunculatum

Hepatoprotective Saikosaponin Homologs from Comastoma pedunculatum

“…The genus Comastoma is in the family Gentianaceae and comprises 17 species worldwide [2]. Phytochemical investigations of this genus have revealed a number of structurally diverse metabolites, such as xanthones, flavonoids and oleanolic acid, triterpenoids, steroids, lignins, coumarin, and long-chain alkanes [3][4][5][6][7]. In the course of our investigations on the constituents of C. pedunculatum, we have reported the isolation and characterization of xanthones [8,9], which are characteristic chemical constituents of the Comastoma genus, and flavone glycosides [10].…”

“…The monosaccharides obtained by acid hydrolysis of each compound were identified by Abstract ! Eight new triterpenoid saponins, the saikosaponin homologs comastomasaponins A-H (1)(2)(3)(4)(5)(6)(7)(8), as well as a known triterpenoid (9) and eight known saponins (10)(11)(12)(13)(14)(15)(16)(17) were isolated from the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated spectroscopically, and their hepatoprotective activity and cytotoxic activity were evaluated against five human tumor cell lines in vitro.…”

“…The structures of these compounds were elucidated spectroscopically, and their hepatoprotective activity and cytotoxic activity were evaluated against five human tumor cell lines in vitro. Compounds 1,[5][6][7][8][9][10][11][12]14,15, and 17 exhibited potent hepatoprotective activity, and compound 11 displayed cytotoxic activity against HCT-8, Bel-7402, BGC-825, A549, and A2780 human tumor cell lines.…”

“…Compounds 1-17 were evaluated for their hepatoprotective activity against D-galactosamine-induced toxicity in WB-F344 cells, using the hepatoprotective drug bicyclol as the positive control [22]. Compounds 1,[5][6][7][8][9][10][11][12]14,15, and 17 exhibited potent hepatoprotective activity (l " Table 3).…”