Phytochemical evaluation and exploration of the hepatoprotective activity of 5 different formulations in CCL4 induced albino RATS

Abstract

Background: Hepatotoxicity and Liver disorders are chronic disorders due to different causes. It affects people in their prime of life, predominantly between the ages of 25-75 years with unpredictable courses. The different formulations are assumed to have significant activity in the treatment of the Liver disorders. Objective: The present study planned to evaluate the synergistic efficacy activity of the different formulations using CCL4 induced hepatotoxic model albino rats. Materials & Methods:The Phytochemical analysis of the T.cordifolia and five different formulations were performed. The animals were divided into eight different groups of 6 animals each as CCl4 treated, Single Plant extracts treated and another different test drug treated groups except 1st group, which was treated with only normal saline. The drugs were administered orally, twice a day and continued for 20 days. On the last day, all the group of animals were treated with the 1ml/kg CCl4 I.P. The Statistical significance was assessed using One-way ANOVA. Results: It was observed that 5 different formulations, i.e. Herbolive Syrup, Hepatonej Syrup, Hepanej Capsule, Herbolive Capsule, and Hepatonej Capsule produced significant hepatoprotective effect on 21st day. All the Formulations have significantly reduced the elevated level of Total Bilirubin, Direct Bilirubin, SGPT, SGOT, and ALP level. Conclusion:The result reveals that all the Herbomineral formulations possess the better hepatoprotective activity compare to single T.cordifolia plant extract. It is due to synergistic action of the various plants and minerals used into the formulation which brings down the elevated liver damage parameter to almost normal level.

Leaf Extracts of Moringa oleifera Cultivated in Baghdad: Characterization and Antimicrobial Potential against Endodontic Pathogens

“…Tese results are in agreement with diferent previous studies that studied the phytochemical screening of ethanolic and aqueous M. oleifera extracts [26,[54][55][56]. While Patel et al [57] indicated the presence of the same compounds in both ethanolic and aqueous extracts, but tannins were detected only in the ethanolic extract and glycoside was lacking in both extracts. Phenolic acids are derived from hydroxybenzoic acid and hydroxycinnamic acid which are naturally present in plants, while favonoids are synthesized by the plant in reaction to microbial infections, with a benzo-c-pyrone ring as a common structure [58].…”

“…Flavonoids such as luteolin, quercetin, and rutin also possess inhibition activity against C. albicans [86]. However, the current results disagree with Moyo et al [95] and Patel et al [57] who found no antifungal activity of M. oleifera aqueous and ethanolic extracts against C. albicans. Tis diference is possibly due to the variation in the chemical composition and quantity of compounds in the extracts of the current study as a result of diferences in environments from which the plant leaves were gathered, the season, and the physiological status of the plant [95].…”

“Regulation of Obesity and Fatty Liver by Moringa oleifera: Insights into Inflammatory Pathways”

“…Traditionally, MO has been employed extensively for the treatment of malaria, typhoid, hematological, cardiovascular and gastrointestinal disorders [16]. Several studies have demonstrated the presence of secondary metabolites vitamins (A, B, C), alkaloids, glycosides, flavonoids, tannins, saponins and terpenoids in MO tree [17]. Some flavonoids (myricetin, quercetin, kaempferol, isorhamnetin and rutin) present in MO leaves and seeds showed excellent antimicrobial and antiproliferative (inhibits S and G2M pathways) and anti-apoptotic effects (downregulate nuclear factor kappa-B) [18, 19].…”