Phytochemical Evaluation and In-Vitro Antibacterial Properties of the Methanolic Leaf Extract of Boswellia dalzielii Hutch. (Burseraceae)

Yakubu

et al. 2020

EJMP

Self Cite

Aim: This research work aimed to establish scientific basis for the use of Boswellia dalzielli stem bark, in traditional medicine as anti-epileptic medication. Methodology: The fresh stem bark of Boswellia dalzielii was extracted using absolute ethanol and screened for phytochemicals. Acute toxicity study was carried out using Lorke’s method and the antiepileptic activity was evaluated using maximal electroshock induced seizure test in day-old broiler chicks and pentylenetetrazole (PTZ) using Wistar strain mice. Results: Phytochemical screening of ethanol extract of B. dalzielii stem bark revealed that the presence of saponins, tannins, flavonoids and steroids/terpenoides. The intrapertoneal median lethal dose value (LD50) of BDE in mice was 2592.3 mg/kg, indicating the stem bark extract is relatively safe. The extract at the dose of 500 mg/kg body weight protected 40% of animals against PTZ-induced convulsion and also protected 20% of chicks against Tonic Hindlimb Extension (THLE) phase of the Maximal Electroshock Test (MEST) significantly (p<0.05). Conclusion: The antiepileptic investigation suggests that ethanol extract of B. dalzielii stem bark has antiepileptic activity.

Section: Discussionsupporting

confidence: 93%

Phytochemical and Anti-epileptic Studies of Ethanol Extract of Boswellia dalzielii (Frankincense Tree) Stem Bark

Yakubu

et al. 2020

EJMP

Self Cite

“…This plant is widely used in African traditional medicine to treat diarrhea, malaria, vomiting, infection, and arthritis (Alemika et al, 2004;Kafuti et al, 2017;Mbiantcha et al, 2018). It is used to cure gastrointestinal problems, leprosy, septic sores, skin illnesses, rheumatism, and a wide range of microbiological ailments (Kubmarawa et al, 2005;Mamza et al, 2018;Olukemi et al, 2005;Otitoju et al, 2019). The people of Northern Nigeria have long utilized decocted root bark to cure diabetes (Table I) (Yakubu et al, 2020).…”

Section: Ethnopharmacologymentioning

confidence: 99%

“…Antimicrobial resistance is being exacerbated by the creation and spread of drugresistant bacteria with new resistance mechanisms, putting our capacity to treat common diseases in jeopardy (Abdulrahman et al, 2019). The extract's spectral index intensity was determined to be positive against all the tested pathogens (Mamza et al, 2018). The antimicrobial evaluation sheds light on the antibacterial potential of the plant parts.…”

Section: Antibacterialmentioning

confidence: 99%

“…The methanolic stembark extract spectral intensity index was determined to be 7.27 mm against all pathogens tested. The presence of secondary metabolites in the plant caused the observed sensitivity (Mamza et al, 2018). Terpene compounds have been reported to have a strong antibacterial effect on both Gram-negative and Volume 33 Issue 4 (2022) Gram-positive bacteria (Martins et al, 2003).…”

Section: Antibacterialmentioning

confidence: 99%

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Ethnopharmacology, Biological evaluation and Chemical composition of Boswellia dalzielii Hutch: A Review

et al. 2022

The Burseraceae family consists of 18 genera and 540 species. Boswellia dalzielii is a medicinal plant used in tropical and subtropical areas for the treatment and management of various ailments. Despite the medicinal value of B. dalzielii, there is no comprehensive documentation. The study aimed to review the ethnopharmacology, biological evaluation and chemical composition of B. dalzielii. Scopus, Web of Science, BioMed Central, Science Direct, PubMed, Springer Link, and Google Scholar were searched to find published articles. The results showed that the leaves, stem bark, and root of B. dalzielii have been traditionally used in Nigeria, Cameroon, Burkina Faso, Benin, Sudan, and Guinee for the treatment and management of antirheumatic, antispasmodic, analgesic, antiseptic, hypotensive, malarial mental illness, ulcer, pain, and fever. It is also found that leaves, stem bark, and root have antioxidant, antibacterial, antifungal, and antimalarial properties with stembark having the highest activity. Chemically, it was revealed the leaf has high contents of monoterpenes hydrocarbons with alpha-pinene as the major compound. The species were largely studied in vitro, according to the literature survey. A well-designed clinical experiment is required to obtain conclusive evidence on the efficacy of stembark. The standard dose and safety of the stembark should be established.

“…Gastrointestinal issues are a common health problem in humans, affecting a significant percentage of the global population, with estimates suggesting it may impact 15 to 20% of people worldwide [25]. The primary antispasmodic medications are anti-muscarinic substances, which are derived from the plant belladonna and their synthetic derivatives, and calcium channel blockers like otilonium and pinaverium [26].…”

Section: Introductionmentioning

confidence: 99%

GC-MS analysis, Elemental and Nutritional Composition and Biological Investigation of Medicinally Valued Fingerhuthia africana Lehm.

Ullah,

Adil,

Filimban

2023

Preprint

Fingerhuthia africana Lehm belongs to family Poaceae, is an erect perennial grass used traditionally to cure different diseases. The current study was carried out to find the bioactive compounds by GC-MS, elemental analysis through atomic absorption spectrophotometry, proximate analysis by AOAC, genotoxic activity through comet assay, antioxidant activity through DPPH and antidiarrheal activity through castor oil induce diarrhea followed by charcoal meal on mice model. GC-MS chromatogram represents different compounds detected in the crude extract. Major pharmacological bioactive compounds are 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl-; 4-Methyl itaconate; .alpha.-Terpineol; 1,2,3-Propanetriol, 1-acetate; Benzofuran, 2,3-dihydro-; Caryophyllene oxide; Hinesol; n-Hexadecanoic acid; 9,12-Octadecadienoic acid (Z,Z)-, methyl ester; Hexadecanoic acid and methyl ester. Elemental analysis of stem, leaves and roots of the plant show the presence of (macro and micro) nutrients such as Ca, Mg, K, Na, Cu, Pb, Zn, Mn, Fe, Cd and Co were absent in all parts. Proximate analysis of different parts revealed the presence of moisture contents (8.57%), ash (9.77%), fats contents (5.96%), fibers contents (45.03%), protein (3.62%), carbohydrates (39.71%) and Gross energy (Kcal/100g) (220.10). The ethanolic extract show dose-dependent genoprotective potential (127.38 ± 1.16), (83.28 ± 0.65), and (44.08 ± 1.40) at 50, 75, and 100 mg/100 ml, respectively, as compared to the methanolic extract which show genotoxic activity (85.13 ± 1.23) at high dose. After 90 minutes at a concentration of 300 (g/ml), methanolic extract demonstrated the greatest antioxidant potential (79.5%), followed by aqueous extract (76.5%). The methanolic extract of F. africana demonstrated antidiarrheal efficacy, with the maximum inhibition of charcoal movement (83.78%) occurring at a dosage of 300 mg/kg, followed by doses of 200 and 100 mg/kg, 73.26% and 59.56%, respectively. The current research highlights that the plant contains a substantial quantity of micro and macro nutrients, possesses high nutritional value, and exhibits pharmacological activities. These properties render the plant suitable for developing remedies to treat various therapeutic diseases.