Phytochemical evaluation, GC-MS analysis and antimicrobial activity of the leaves petiole of Artocarpus heterophyllus Lam

Kurian, Susan; Joseph, Leenamma; Josekumar, V. S.

doi:10.31024/ajpp.2018.4.3.7

Cited by 4 publications

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“…The hepatic cells showed severe toxicity which is characterized by centrilobular necrosis, dilated sinusoidal spaces and nodule formation. Phytochemical screening of the hexane, ethyl acetate and methanol extracts of leaf petiole of A. heterophyllus showed a higher concentration of saponins, alkaloids, tannins, phenols, flavanoids, quinones, steroids and terpenoids in methanol extract than other two extracts [6,7] . Methanolic extract of A. heterophyllus was demonstrated to be hepatoprotective in action through its antioxidant property in APAP intoxicated experimental rats.…”

Section: Resultsmentioning

confidence: 99%

“…The solvents were removed from the extracts using rotary vacuum evaporator and stored in the refrigerator for further analysis. Phytochemical analysis and the antioxidant property of the extracts showed highest activity with AHM [6,7] . So AHM was selected for further investigations.…”

Section: Preparation Of Plant Extractsmentioning

confidence: 99%

“…Artocapus heterophyllus (A. heterophyllus) (Jackfruit), belonging to Moraceae is reported to have anti-inflammatory, antidiuretic, antioxidant, antifungal and immunomodulatory properties [4,5] . Various studies revealed the diverse secondary metabolites present in its fruits and seeds [6][7][8][9] . Hepatoprotective activity of aqueous extract of seed, leaf and fruit of A. heterophyllus was reported earlier with Carbon tetrachloride (CCl 4 ) induced hepatotoxicity on Swiss albino mice [10][11][12] .…”

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confidence: 99%

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Leaf Petiole of Artocarpus heterophyllus Lam. Protect Acetaminophen Induced Hepatotoxicity through Antioxidant Defense in Albino Rats

Kurian,

Joseph,

Josekumar

2024

IJPS

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Hepatoprotective activity of Artocarpus heterophyllus Lam. leaf petiole through antioxidant systemArtocarpus heterophyllus Lam. is the common jackfruit tree belongs to family Moraceae. The protective role of leaf petiole part of the plant was investigated in experimental hepatotoxicity. Antioxidant enzyme activity was investigated in acetaminophen intoxicated rat liver treated with methanol extract of Artocarpus heterophyllus. Phytochemical analysis and the antioxidant property of successive hexane, ethyl acetate and methanol extracts of Artocarpus heterophyllus showed highest activity with methanol extract (Artocarpus heterophyllus). Superoxide dismutase, catalase (antioxidant enzymes) and glutathione showed significant increase in rats with oral administration of Artocarpus heterophyllus compared to the acetaminophen treated group. The degree of hepatoprotection was assessed by the activity of aspartate amino transferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transpeptidase. A dose dependant protective effect of Artocarpus heterophyllus (200 mg/kg body weight, 400 mg/kg body weight) against acetaminophen-induced hepatotoxicity in albino rats was identified. Histopathological evaluation of the liver confirmed the hepatoprotective function of methanol extract of Artocarpus heterophyllus as evident in biochemical evaluations. The results of the present study suggest the potential use of leaf petiole of Artocarpus heterophyllus in the treatment of liver disease due to its ability to protect as an antioxidant.

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Section: Resultsmentioning

confidence: 99%

Section: Preparation Of Plant Extractsmentioning

confidence: 99%